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Dosage in mg/kg (for 2C-x, MDxx, etc)

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TheAzo

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People often report fairly different dosage levels for the same drugs. Yet of course we all report our dosages in mg, rather than mg/kg. For most drugs (medical and otherwise), there is an approximately linear relationship between weight and active dose.

I think it's quite possible that a large portion of the differences in doses that people find appropriate for these substances is due to differences in bodyweight. I think it would be useful to investigate this, especially considering the very steep dose-response curves of some psychedelics, and the number of questions posted here about dosage.

Most people reccomend doses 50-100% higher than i would want to take, but i weigh ~60kg...

So in your experiences with common RC's and psychedelics (most interested in 2C-E/I and the MDxx's), what would you consider a normal dose, and what is that for you in mg/kg?

I get good effects from 2C-I/E in the 10-15mg range, which is .16-.25 mg/kg.
 
I used to think of it like this but it seems serotonergic psychedelics don't conform to this rule.

A lot of big guys get blown away by what a skinny person would consider a lowish dose.

I'm 5'11" and 120lbs and 20mg of 2C-I does me good. It's more about your personal makeup/how you're wired than body weight.
 
i would agree that it has more to do with genetics and individual brain chemistry.
but a good dose of 2ce for me is 17 mg. maybe 14-18 mg to be more broad.
so .2 mg/kg - .25 mg/kg
with a "sweet spot'' of .24 mg/kg
i'm about 70 kg
 
i dont think that body weight would make a difference with MDxx substances because it would be more about the seritonin in your brain and that varies with everyone. I am 120 lbs and I have taken up to 500mg of MDMA in the course of a night and handled it fine. But I know someone who is 110lbs and 100mg puts her almost over the edge of what she can handle. Like PepperSocks said, its more about your personal makeup etc
 
Indeed. For me 500mg of MDMA would make me a completely sped up, sketched out mess and then leave with the most incapacitating hangover for weeks to come.

120mg is a good dose, anything over 150 makes it sketchy and takes away any positive effects, also makes for a hideous hangover.
 
^^lower doses are always a little speedier for me....

Larger amounts of serotonin in my brain has me on the floor.

For some people less can be a more enjoyable experience.

A friend of mine is on the heavier side, so for his first experience with molly i gave him a little more than a tenth, and for most of the night he just sat by the camp fire. He really just wanted to chill.

For his next time i ended up giving him a little it less than a tenth, and that seemed to be what he considers to be a perfect dose for what he wants to get out of it. It was enough to make him a bit more social, add to the music, and just be in a good mood without being too fucked up and wanted to just sit down and get comfortable.

For me, i never go that low, 120-150mg is perfect for me at 70kg, friend maybe weighs like 90kg.

250mg of molly, 2 hits of bomb acid, and a nitrous balloon had me in outer space for a couple minutes.

Again another drug that seems to be better on the lower side is 2c-i, a friend that i gave a bunch to just to fuck around with enjoyed a 20mg dose far more than anything higher.
 
^ I'm really starting to find I get a lot more out of lower doses.

I always thought Shulgin low balled the doses but I think once you learn how to navigate a psychedelic less material is needed. It also reduces the side effects by a big margin.

I'm really finding less is more.

150-200ug of LSD might be considered a really low dose to some people but it puts me right in that perfect state. Wide open, incredibly revealing, my thoughts really integrate and repressed stuff really hits home, but it's not grating or overkill. :)
 
Again another drug that seems to be better on the lower side is 2c-i, a friend that i gave a bunch to just to fuck around with enjoyed a 20mg dose far more than anything higher.
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I have done 2c-i a few times, and both times I took 20mg. It seems like the perfect amount for me, I dont know if I would want to do a higher does than that. Always at the end of the trip I need to smoke quite a bit of pot to calm my body down as it gives me so much energy, which is usually fun until I want to relax:|
 
dosing for psychedelics has little to do with your body weight and more to do with your mental capability to handle the experience.

Ive seen huge guys turn into wimpering girls from 2.5g of mushrooms. And seen real skinny guys eat heroic doses and be fine.
 
PepperSocks said:
150-200ug of LSD might be considered a really low dose to some people but it puts me right in that perfect state. Wide open, incredibly revealing, my thoughts really integrate and repressed stuff really hits home, but it's not grating or overkill. :)
Click to expand...

Gotta agree. 150ug of LSD is the sweet spot. %)
 
Yeah, agreed.

Compounds with steep dose-response curves also mean that even with varying receptor prevalence the difference is not that big, proven by 2C-E which generally has like an 18 mg sweet spot or something.
Still has nothing to do with the fact that mg/kg approach is inadequate with psychedelic so sorry but don't see a future for this thread..
 
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