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Dopaminergics.

narutokun

narutokun

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Aug 21, 2007
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I need to know if anyone can list me a list of dopaminergics without adrenergic effects (amphetamines, cocaine, mph, the works that lead to muscle tension, tachycardia, etc. I want them out of the picture, I can't stand all these cardiac stimulation anymore). I heard about a qualadone that had dopaminergic effects only, along with the normal depressive effects. Thanks.
 
I can't think of any in common use. Unless you have access to research grade DARIs, you probably can't get any.

There are no *qualones that are also DARIs, but obviously methaqualone has some downstream effect.
 
^I'm sorry what I meant was any quinazolinones with dopaminergic properties I think I read that somewhere. And no I don't have access to research DARIs. I just wanna know a few compounds without andrenergic effects so I can make some research on them. And maybe in the future synthetise some for personal use since there are none commercialy available.
 
Yeah sorry I guess I misspelled. I'm sure I read somewhere that some analogues were dopaminergic though.
 
Jamshyd said:
You seem to forget that Dopamine itself breaks down to norepinephrine (which in turn breaks down to adrenaline)...?
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Yes but I think you're missing my point. I was asking about a compound that only deals with dopamine alone, not releasing norepinephrine or other monoamines, like coke and the such does; the adrenergic effects are most pronounced because of the inherent NE release not from the dopamine breakdown. The breakdown doesn't really matter that much in that case.
 
narutokun said:
Yes but I think you're missing my point. I was asking about a compound that only deals with dopamine alone, not releasing norepinephrine or other monoamines, like coke and the such does; the adrenergic effects are most pronounced because of the inherent NE release not from the dopamine breakdown. The breakdown doesn't really matter that much in that case.
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I understand.

Now consider this: In your OP, what you described as "dopaminergic" effect is what is usually referred to as "central effect", and what you refer to as "adrenergic" is referred to as "peripheral effect". In reality, each catagory of effect is not exclusive to its respective transmitter that you assign.

The interplay between monoamines and their drugs is far too complicated to make statements that a purely dopaminergic drug would be free of the side-effects you desire.

So lets go back to peripheral vs central - in that case, you'll get lots of answers. Check out the huge stim thread in this forum, for example. A classic stimulant in which peripheral effects generally outweigh any central ones is Ephedrine. This is due to its poor crossing of the BBB, and in fact shulgin uses this pretense to explain why MDx analogues of ephedrine are not worth researching.

An "ideal" centrally-acting psychostimulant would be, according to FnB at least (=D), fencamfamine, which according to him, completely lacks any peripheral side effects.

One odd compound that comes to my mind is Amantadine. While it is an NMDA antagonist, its main mode of action is purely through interaction with Dopamine. (Although I did find snippets of it being anti-cholinergic as well).
 
Some of the dopaminergic effects are things like muscle tension (dopamine controls such things, which is why Parkinson's disease sufferers are so impaired).

In terms of no physical side effects (or at least very few) the best ones I can think of are indeed fencamfamine, desoxypipradrol or pipradrol. All three are almost purely 'mental stimulants' without attending physical symptoms. One I recently discovered which is pretty much free of any physical symptoms was fluorotropacocaine (pseudotropyl 4-fluorobenzoate) - also as it's not a local anaesthetic, none of cocaine's cardiotoxicity (still felt like coke though as I behaved like a real arrogant fuckwit)
 
I thought that amantadine was completely without recreational potential?

I can't find any evidence that it's a recreational NMDA antagonist... Looks like most other antivirals of it's class.
 
^ There are a few trip reports on it, and to me it sounds like a cross between Dizocilipine and Diphenhydramine. In any case, at medicinal doses it is reported to work very much like memantine (with neurodegeneretive disorders) along with a slight dopaminergic mood-lift.

I will be accquiring some soon just to test at low doses if it would substitute for my low-dose medicinal ketamine.
 
I was prescribed phendimetrazine as an anorectant. It worked great for ADD and narcolepsy though too. Perfect for every day operations where other stims seem to fall short.

I wish more research would be put into these pipradols etc... Only shorter acting. I have had a pemoline prescription before and it was pretty good but the down side was I would never turn off and sleep. This is taking the normal dose in the morning.

n-demethylated adrenaline is nor-adrenaline so in the case of normal bodily functions of N-demethylation epi can change to NA.
 
Here is a table that suggests what the most dopamnergic drugs are. This list is not the end all of all lists though.

stimtable.png


phendimetrazine first pass n-demethylation produces phenmetrazine which is a very potent dopamanergic but with minimal serotonergic properties. My bp and heart rate actually decreased with its use.
 
Great chart if it is indeed accurate, but why do they put so many zeros after the 10s, initially I was reading 10.000 instead of 10. Getting a closure on this then, what is the best compound with the most dopamine release and reuptake with the least NE release and reuptake?
 
swilow said:
I thought nor-adrenaline cam from adrenaline??
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Other way around.
It goes tyrosine -> DOPA -> dopamine -> NA -> adrenaline.

So dopamine doesn't exactly "break down" to NA, but it can be converted to NA by cells containing dopamine b-hydroxylase ie. DAergic neurons.
Principle product of DA metabolism is homovanillic acid.
 
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