Misc Domperidone - acts as a dopamine antagonist. Causing bad effects??

[Oxy8_8]

I won't go into the details because to be perfectly honestly, I think people will give up bored before they reach the end lol, but if you're curious, google is your friend!
Anyway, while reading the information leaflet of my Domperidon (I was having a particularly bad stomach problem and wanted to check it was ok to take two) I discovered that they were a dopamine antagonist.
I know you can't always trust what you read online, but I have searched several sites and it seems that - as a dopamine antagonist - it will bind itself to dopamine receptors in the brain and block them from working (I'm not sure whether partially or fully. I would imagine partially but significantly) and therefore would diminish the amount of dopamine given out and theus decrease the amount of pleasure you get from any given activity.

Is this tru? Does anybody more scientifically inclined than me know the details?
I was also slightly confused that there was things called "dopamine agonists" and "dopamine antagonists" but that the two do practically the opposite things?

It's scary to think every day household medications could be hampering your high.

 

[thesameoldfears]

I was also slightly confused that there was things called "dopamine agonists" and "dopamine antagonists" but that the two do practically the opposite things?

How is this confusing?

From wikipedia "agonist" page:
"An agonist is a chemical that binds to some receptor of a cell and triggers a response by that cell. Agonists often mimic the action of a naturally occurring substance. Whereas an agonist causes an action, an antagonist blocks the action of the agonist and an inverse agonist causes an action opposite to that of the agonist."

Agonists and antagonists are by definition opposites.

 

[Oxy8_8]

How is this confusing?

From wikipedia "agonist" page:
"An agonist is a chemical that binds to some receptor of a cell and triggers a response by that cell. Agonists often mimic the action of a naturally occurring substance. Whereas an agonist causes an action, an antagonist blocks the action of the agonist and an inverse agonist causes an action opposite to that of the agonist."

Agonists and antagonists are by definition opposites.

Confused because I smoked a bowl or three haha

So is my basica theory that the tablets will decrease dopamine production and therefore dopamine levels, which would in turn cause the person who had taken them to need more what [whatever pleasure of choice] in order to feel satisfied?

 

[Limpet_Chicken]

I won't take the stuff. Unless i really, really really have to.

Makes my fingers stiffen up, and other borderline dyskinetic shite happens, nasty stuff and makes wthdrawals from opioids a fucking ton worse.

 

[paranoid android]

I was given a prescription for it as i have brutal stomach problems but after reading the side effects i never even took 1 pill. It is a dopamine antagonist but it supposedly does not cross the blood brain barrier. That is what makes it different from metoclopramide basically as the 2 drugs are otherwise the same. It supposedly doesn't come with the side effects such as tardive dyskinesia which occurs in as high as 25% of people taking it daily for 3 months or more. Domperidone can still cause lactation due to the increase in prolactin levels due to the dopamine blockade and that is a pretty common side effect from what I've heard. Also it doesn't work right away it usually takes a few days to fully work as it helps speed up the emptying of your stomach along with being a dopamine antagonist. If you need something to work right away a OTC anti-nausea drug such as dimenhydrinate or a prescription one such as promethazine or prochlorperazine (brand names stematil, stemazine, compazine, etc) would help more.