^ If it is your first mushroom experience that would kind of break the unwritten rule of not combining drugs for your first time (especially not 2 drugs both of which you take for your first time).
I do think it matters whether you have extensive experience with psychedelics or not, the above would probably be a more unwise plan than smoking weed on the tail end of a pleasant trip with a new substance if you are a frequent flyer.
Anyway about the topical question: IMO it is best - when possible - to build up your experience with psychedelics more or less based on their general intensity. Right now I am not just talking about what is responsible or about psychological tolerance, but that if you consider each new drug that is more and more intense as 'levels' it seems that you can keep it interesting for much longer.
Spoiling might be too strong a word, but when people talk about diving right in the deep end with the ultra intense ones, I think it is a shame that they increase their chances of taking away their own power to be surprised.
Of course it is in the nature of psychedelia to be surprised by thing for quite a while (although at some point the novelty does get less and less).
The turnside of that may be that you experience more novelty in daily life:
I had this idea this week, based on what Nichols said about the locus coeroleus in the brain regulating signalling of novelties and LSD significantly activating this circuit I wondered if tripping chronically could reinforce neuron pathways in a way that would both slowly desensitize the person to that particular effect of psychedelics as well as increasing LC activity even when sober. Isn't that an effect that is textbook neuro(pharmaco)logy?
Sorry if that derails the thread, but it is fascinating to me.