Stimulants Does speed/amphetamine differ greatly from Adderall/dexamphetamine?

[Dextro .45]

Ritalin with food boosts your perceived effect?

Kind of does the opposite for me, seems to blunt it, but I'm using it for cognitive and energy boosting effects.

I understand you use ritalin as a part of a pain reduction combination, which may explain why it works well in your case as a euphoriant?

During anxiety periods, Xanax and Valium were insanely euphoric in my case, but taken under normal terms they just make me feel drowsey.

Taking Methylphenidate with a fatty meal speeds/aids absorption (healthy breakfast with animal fats, toasted egg ham sandwich etc)

Also, more importantly….taking Methylphenidate with Ethanol/alcohol increases levels of the active isomer dextro-threo-methylphenidate (Focalin) d-MPH by 40% significantly increasing euphoric subjective effects in all study participants (from a medical journal study MPH & Ethanol in adult participants)

the liver enzymes that metabolizes d-MPH are too occupied metabolizing the Ethanol as well, so less d-MPH is destroyed through first pass metabolism……reaching significantly greater levels in the CNS - 40% approx increase


That being said …..when initiating Ritalin (Methylphenidate) I didn’t do any of that and still experienced VERY pleasurable euphoria from low doses, 10mg even first time……wow, I feel incredibly good, happy, talkative, warm & fuzzy, euphoric, nearly identical to Oxycodone pleasure

Oxy & Rita taken orally were easily the most euphoric pleasure I’ve ever gotten

Pharmaceuticals are unmatched …..a nice clean tablet/capsule of 100% pure unadulterated compounds that haven’t been diluted/cut with shit. Safe & pure.

Vyvanse (Lisdexamfetamine) 20mg = 5.9mg of d-Amphetamine …..gave me and a close friend both experienced heart palpitations on such a low dose, 6mg of Dexedrine taking 3h to reach C-max …WTF? I take 50-70mg of Ritalin IR and Never ever experienced Any concerning cardiovascular issues what so ever…..nothing in 20+ years of daily dosing IR Ritalin. Incredibly safe Dopaminergic stimulant while still possessing striking euphoric qualities matching Cocaine and Phenmetrazine (in larger injection use of pure pharmaceutical CIBA compounding powder of MPH)

The only stimulant I’d select over IR Ritalin would be genuine Ovation Pharma Desoxyn 5mg tablets in 5-25mg dose (also having a reduced cardiovascular payload - reduced increase in HR & BP in appropriate therapeutic doses)

……oh and ya. an Anxiolytic like Diazepam is an absolute staple …how could in not be added into a carefully constructed cocktail

 

[JohnBoy2000]

Taking Methylphenidate with a fatty meal speeds/aids absorption (healthy breakfast with animal fats, toasted egg ham sandwich etc)

Also, more importantly….taking Methylphenidate with Ethanol/alcohol increases levels of the active isomer dextro-threo-methylphenidate (Focalin) d-MPH by 40% significantly increasing euphoric subjective effects in all study participants (from a medical journal study MPH & Ethanol in adult participants)

the liver enzymes that metabolizes d-MPH are too occupied metabolizing the Ethanol as well, so less d-MPH is destroyed through first pass metabolism……reaching significantly greater levels in the CNS - 40% approx increase


That being said …..when initiating Ritalin (Methylphenidate) I didn’t do any of that and still experienced VERY pleasurable euphoria from low doses, 10mg even first time……wow, I feel incredibly good, happy, talkative, warm & fuzzy, euphoric, nearly identical to Oxycodone pleasure

Oxy & Rita taken orally were easily the most euphoric pleasure I’ve ever gotten

Pharmaceuticals are unmatched …..a nice clean tablet/capsule of 100% pure unadulterated compounds that haven’t been diluted/cut with shit. Safe & pure.

Vyvanse (Lisdexamfetamine) 20mg = 5.9mg of d-Amphetamine …..gave me and a close friend both experienced heart palpitations on such a low dose, 6mg of Dexedrine taking 3h to reach C-max …WTF? I take 50-70mg of Ritalin IR and Never ever experienced Any concerning cardiovascular issues what so ever…..nothing in 20+ years of daily dosing IR Ritalin. Incredibly safe Dopaminergic stimulant while still possessing striking euphoric qualities matching Cocaine and Phenmetrazine (in larger injection use of pure pharmaceutical CIBA compounding powder of MPH)

The only stimulant I’d select over IR Ritalin would be genuine Ovation Pharma Desoxyn 5mg tablets in 5-25mg dose (also having a reduced cardiovascular payload - reduced increase in HR & BP in appropriate therapeutic doses)

……oh and ya. an Anxiolytic like Diazepam is an absolute staple …how could in not be added into a carefully constructed cocktail

How much ethanol do you take with ritalin to get that boost?

I hate the cognitive impairment alcohol generates, but that does sound interesting.

Would that 40% increase in blood levels not be the equivalent of just taking 40% more ritalin?

If I go into 50 mg territory, things get unpleasant.

Most folks laugh at 10 mg ritalin, interesting it works so subjectively well for you.

 

[Dextro .45]

How much ethanol do you take with ritalin to get that boost?

I hate the cognitive impairment alcohol generates, but that does sound interesting.

Would that 40% increase in blood levels not be the equivalent of just taking 40% more ritalin?

If I go into 50 mg territory, things get unpleasant.

Most folks laugh at 10 mg ritalin, interesting it works so subjectively well for you.

Ya, 50mg of IR Methylphenidate is a moderately to Very robust dose……as for adult males the standard treatment are 20mg IR tablets X 3 daily (60mg daily)

50-70mg IR Methylphenidate is very robust…..only due to daily administration and tolerance ……in addition the CNS depressants like Opioids and especially Benzodiazepines READY reduce any adverse effects

L-Citrulline 1.5g X 3 daily is a natural health supplement (essential amino acid found naturally in watermelon) and is a VERY potent vasodilator reducing BP & HR ….its the main precursor to Nitric Oxide that dialates the blood vessels causing increased blood flow, reduced cardiovascular stress, lowering HR and BP safely

I’m not saying take 50mg of Ritalin……whatever your tolerance is for a safe dose. Diazepam (Valium), Pregabalin (Lyrica) and Clonidine 0.1mg tablets are always essential to have in the inventory

Especially Diazepam (Valium) 10mg tablets X 3-5 through the day

That’s just my regiment for my situation with chronic pain due to RA….the invaluable oral Brompton Cocktail

Opioid
Dopaminergic stimulant
Benzodiazepine
Gabapentinoid …..taken all together in glass, 30-45min onset

Ethanol cocktails & premium cigarettes…..maybe some Ketamine & Cocaine 50/50 mix, small little lines to enhance the analgesic painkilling properties after the cocktails C-Max is starting to taper off.

My coveted daily cocktail

 

[Leprechaun]

When you look at the pharmacokinetics, there is barely any difference between amphetamine and methamphetamine. In fact the l-isomer is more active with Amphetamine than Methamphetamine.

Here is what is recorded on Wikipedia:

Phenethylamine	10.9	39.5	>10,000
d-Amphetamine	6.6–7.2	5.8–24.8	698–1,765
l-Amphetamine	9.5	27.7	ND
d-Methamphetamine	12.3–13.8	8.5–24.5	736–1,292
l-Methamphetamine	28.5	416	4,640
d-Ethylamphetamine	28.8	44.1	333.0

[th width="39.1045%"]

Compound​

[/th][th width="20.597%"]

NETooltip Norepinephrine​

[/th][th width="18.5075%"]

DATooltip Dopamine​

[/th][th width="21.791%"]

5-HTTooltip Serotonin​

[/th]​

One incredible thing about subjective effects, is that even in supposed non-active compounds, such as "d-pseudoephedrine" found in over the counter/pharmacy decongestant tablets have a notable subjective effect when taken at doses above 60mg, well it is in my experience.

Although d-amphetamine and d-methamphetamine at doses 5mg - 50mg could be said to have an almost identical pharmacological profile, they have subtly different subjective effects.

One thing I did notice however, that d-meth is something I would not want to do, whereas d-amph I don't mind doing.

Primarily because:

1. Culturally d-meth is seen as a "ghetto" drug.
2. D-amph doesn't last so long that it fucks up my routine for 3 days if I do anything more than 10mg in the morning.
3. Is easier to access pure pharmaceutical grade compound.