basically the answer is YES seroquel will block the effects of just about any stimulant you're likely to come across, but only during acute dosing of it concurrent with a stimulant. it is powerful enuff at the right dosages to end just about any stim trip and send you to bed, but it doesn't permanently block any dopamine signaling, only when there is enuff of it in your body to be active. if you take the stuff every day then the dosages will be different, tolerance to seroquel builds rapidly and it lasts a long time, as you know, but after it's worn off it is no longer blocking any receptors and you're good to go. Like basically 15 hours after dosing it and you will be able to get high off of coke/speed/whatever. i have done this many times. anytime before those 15 hours are up however and you are wasting good drugs because those synapses are locked shut when that shit is in there. i have taken seroquel to come down off of meth, woken up and felt groggy after only 5-8 hours sleep, taken more meth and not felt good until hours later when all the seroquel had been mostly metabolized -- then i was totally high again, when all that meth finally caught up with me. it took me several rounds of this to figure out what exactly was happening. strong stuff, that seroquel.
good luck