Hmm so the only reason that tolerance would increase is if the dosage was the same and the absorption rate was different? If say, I plug 10mg versus eating 15mg, it would theoretically be the same?
Yes, I know that plugging is basically like IV'ing a pill. What he's asking is if it could build up a tolerance faster, in which case the answer would be yes because more of the drug is being absorbed then it would orally. This would eventually lead to a higher tolerance.
Yup, its Dexedrine, and I was hoping that if I took a lower than oral dosage, then it would be around the same, if I orally take 20mg versus plugging 15mg, it would be around the same right?
Dexedrine has a BA of >75% according to Wiki, and Plugging is USUALLY around 80-95% BA, so techincally speaking if you took 10mg orally you'd only be absorbing 7.5mg, and if you plugged it you'd be absorbing 8-9.5mg.
Since some drugs are absorbed more when you plug versus taking it orally I would have to say yes, you could build up a tolerance a lot quicker plugging.