Does L-dopa effect the MDMA experience?

[the_integerian]

I am thinking about trying x for the first time. I take 100 mg of L-dopa every morning (from Mucuna Pruriens extract). Will the L-dopa effect my extacy experience in any way?

 

[dcraver877]

bump. i've been taking mucuna today and want to roll tonight. Will it help? I'm having slight kratom withdrawals so I think the mucuna is necessary for me to enjoy the night....or soemthing else that calms me and gets rid of the chills

 

[Darksidesam]

Don't take L-Dopa before mdma.

phenylalanine > Tyrosine > L-DOPA > Dopamine

http://www.jneurosci.org/content/26/1/290.full.pdf

The specific mechanisms underlying ()-3,4-methylenedioxymethamphetamine (MDMA)-induced damage to 5-HT terminals are unknown. Despite the hypothesized role for dopamine (DA) and DA-derived free radicals in mediating this damage, it remains unclear why
MDMA produces long-term depletions of 5-HT in brain regions that are sparsely innervated by DA neurons. We hypothesized that the
precursor to DA biosynthesis, tyrosine, mediates MDMA-induced 5-HT depletions. Extracellular tyrosine concentrations increased
fivefold in striatum and 2.5-fold in hippocampus during the administration of neurotoxic doses of MDMA. In vitro results show that
L-tyrosine can be hydroxylated nonenzymatically to the DA precursor L-3,4-dihydroxyphenylalanine (DOPA) under pro-oxidant conditions. The local infusion of L-tyrosine into the striatum or hippocampus during MDMA administration potentiated the acute increase in
extracellular DA and the long-term depletion of 5-HT after MDMA. Coinfusion of the aromatic amino acid decarboxylase (AADC)
inhibitor m-hydroxybenzylhydrazine attenuated these effects in hippocampus and decreased basal extracellular DA in the striatum. In
contrast, the reverse dialysis of the tyrosine hydroxylase inhibitor -methyl-p-tyrosine into the hippocampus did not affect MDMAinduced increases in extracellular DA or the long-term depletion in 5-HT. These results show that MDMA increases the concentration of tyrosine in the brain to cause a long-term depletion of 5-HT via the nonenzymatic, tyrosine hydroxylase-independent, hydroxylation of tyrosine to DOPA and subsequently to DA via AADC. Overall, the findings suggest that MDMA depletes 5-HT by increasing tyrosine and its eventual conversion to DA within 5-HT terminals

 

[dcraver877]

yea but i took it over 10 hours before. I also took kratom just now. In the spirit of harm reduction, i will let you know if I die or whatnot.

 

[Foreigner]

Don't take L-Dopa before mdma.

phenylalanine > Tyrosine > L-DOPA > Dopamine

http://www.jneurosci.org/content/26/1/290.full.pdf

The specific mechanisms underlying ()-3,4-methylenedioxymethamphetamine (MDMA)-induced damage to 5-HT terminals are unknown. Despite the hypothesized role for dopamine (DA) and DA-derived free radicals in mediating this damage, it remains unclear why
MDMA produces long-term depletions of 5-HT in brain regions that are sparsely innervated by DA neurons. We hypothesized that the
precursor to DA biosynthesis, tyrosine, mediates MDMA-induced 5-HT depletions. Extracellular tyrosine concentrations increased
fivefold in striatum and 2.5-fold in hippocampus during the administration of neurotoxic doses of MDMA. In vitro results show that
L-tyrosine can be hydroxylated nonenzymatically to the DA precursor L-3,4-dihydroxyphenylalanine (DOPA) under pro-oxidant conditions. The local infusion of L-tyrosine into the striatum or hippocampus during MDMA administration potentiated the acute increase in
extracellular DA and the long-term depletion of 5-HT after MDMA. Coinfusion of the aromatic amino acid decarboxylase (AADC)
inhibitor m-hydroxybenzylhydrazine attenuated these effects in hippocampus and decreased basal extracellular DA in the striatum. In
contrast, the reverse dialysis of the tyrosine hydroxylase inhibitor -methyl-p-tyrosine into the hippocampus did not affect MDMAinduced increases in extracellular DA or the long-term depletion in 5-HT. These results show that MDMA increases the concentration of tyrosine in the brain to cause a long-term depletion of 5-HT via the nonenzymatic, tyrosine hydroxylase-independent, hydroxylation of tyrosine to DOPA and subsequently to DA via AADC. Overall, the findings suggest that MDMA depletes 5-HT by increasing tyrosine and its eventual conversion to DA within 5-HT terminals

Translation: L-dopa will make your come down from MDMA way worse and the effects last much longer.

 

[Darksidesam]

I used to take l-tyrosine daily and i ended up taking mdma one night forgetting i was taking that daily and the comedown was worse than usual.