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Ketamine Does ketamine build a permatolerance?

in my experience it does to a degree. I heve a friend that was fucking ADDICTED to ketamine and even after taking breaks for years he can still barely feel it regardless of how much he takes. The ketamine he gets is fucking FIRE too. Some of the strongest I’ve ever had. Poor guy.
 
hi, first post (yay)
i had some bouts where i did ketamine almost daily for i'd say a month or two, in general do it oftenish, when i get a bit i generally run through it in a week or two.
have certainly noticed massive tolerance buildup over the years, even after not having done any for months. 100-150mg used to knock me out, and now it barely puts me anywhere.
Keep in mind my use is generally borderline k-hole / psychrdelic spaceout dosages, not so much party bumps.
 
6apebillen said:
hi, first post (yay)
i had some bouts where i did ketamine almost daily for i'd say a month or two, in general do it oftenish, when i get a bit i generally run through it in a week or two.
have certainly noticed massive tolerance buildup over the years, even after not having done any for months. 100-150mg used to knock me out, and now it barely puts me anywhere.
Keep in mind my use is generally borderline k-hole / psychrdelic spaceout dosages, not so much party bumps.
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Yeah that's me. 5 grams doesn't even last me a week. I just started noticing that doing a full gram to myself in a night barely puts me anywhere. I thought maybe I got a weeker batch.
 
Yeah to me it does to some extent, I took years break few times, while the first lines felt good (maybe a khole sometimes) after them it's like going almost instantly back to the tolerance of multiple grams a day for months. If i get few vials I do one every 2 days or so to get the most of them and have a break for few months but it's never gonna be the same for sure.
 
You def build a permatolerance. Ive gone through times of doing at least 1.5g daily for months and now I def need a lot more than the average person to get to the same place even after not touching it for months, I can come off a long break and my first 100mg up each nostril won't put me anywhere near where it puts most people.
 
I'd rather be consuming ldd`25. Not special k. Not quite the same but it helps you forget about lsd twenty-five. But everyone who has ever done real actual synthetic lsd-twentyfive always remembers eventually. And this who've never done can't,remember something they've neveractually done or experienced. Fon'be lieing either way. What do you think about the subject of decriminalize synthetic lsd? Yes into. And, why or why not?
 
generation lsd25 said:
I'd rather be consuming ldd`25. Not special k. Not quite the same but it helps you forget about lsd twenty-five. But everyone who has ever done real actual synthetic lsd-twentyfive always remembers eventually. And this who've never done can't,remember something they've neveractually done or experienced. Fon'be lieing either way. What do you think about the subject of decriminalize synthetic lsd? Yes into. And, why or why not?
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I'd rather be doing special k than lsd or any of it's knock offs. This doesn't have anything to do with my thread or question. But to answer yours, I think all substances should be decriminalized and only get people in trouble if people can't handle their shit. Like if someone is smoking meth, fine. But if they're out on the corner yelling at cars and taking shits on park benches worried that the CIA is watching them, they should get charged. That's my opinion. Like not just the regular charges of public indecency and public disturbance and whatever other BS the cops can pull out of their ass, but a meth charge on top of it. I think it should be the same with any drug. That if someone wants to smoke fent, fine. But if they want to fold on the corner outside of stores and shit where parents bring their kids, arrest them. Make them handle their shit. Also I've never had any problems with remembering parts of my LSD trips though I've had friends who've blacked out. I guess I get it because I forgot what all I talked about on my way to the gas station during my first mdma trip, but it eventually came to me. You don't seem like you're all there. You should get approved from a couple of friends and strangers that you can speak and think coherently before you go and ruin LSD's reputation trying to vouch for it through some nonsense.
 
IWantFentanylInMyShit said:
I'd rather be doing special k than lsd or any of it's knock offs. This doesn't have anything to do with my thread or question. But to answer yours, I think all substances should be decriminalized and only get people in trouble if people can't handle their shit. Like if someone is smoking meth, fine. But if they're out on the corner yelling at cars and taking shits on park benches worried that the CIA is watching them, they should get charged. That's my opinion. Like not just the regular charges of public indecency and public disturbance and whatever other BS the cops can pull out of their ass, but a meth charge on top of it. I think it should be the same with any drug. That if someone wants to smoke fent, fine. But if they want to fold on the corner outside of stores and shit where parents bring their kids, arrest them. Make them handle their shit. Also I've never had any problems with remembering parts of my LSD trips though I've had friends who've blacked out. I guess I get it because I forgot what all I talked about on my way to the gas station during my first mdma trip, but it eventually came to me. You don't seem like you're all there. You should get approved from a couple of friends and strangers that you can speak and think coherently before you go and ruin LSD's reputation trying to vouch for it through some nonsense.
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As someone who's done well over 1000 hits of L in less than a decade or two, It's boring as shit after discovering K. I prefer IM or IV, but that's usually when using a sealed vial of Anesket which is pretty much nowhere to be found. I figure dissolving and filtering out contaminants at the bottom that don't dissolve, remeber, gotta do less than 200mg/mL because higher than that and your Ket will get saturated and precipitate out. It will no longer dissolve. A separatory funnel would be best, but work with what you can. ALWAYS use distilled water. Honestly, it's better to only inject out of a sealed vial. Also you'll want to use a micron filter to be sure.
 
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Someone asked a question about this on the rc reddit group, they wanted to reduce their disso tolerance. Obv people said "a long break" which isn't necessarily efficient imo. A more proactive way would be to restore the entire metabolic system and CNS, including the dopamine/glutamate system which I outlined here. No exotic or expensive drugs necessary.

Btw, ketamine has estrogenic effects which I'd avoid regardless of gender.
 
Allylbenzene said:
Someone asked a question about this on the rc reddit group, they wanted to reduce their disso tolerance. Obv people said "a long break" which isn't necessarily efficient imo. A more proactive way would be to restore the entire metabolic system and CNS, including the dopamine/glutamate system which I outlined here. No exotic or expensive drugs necessary.

Btw, ketamine has estrogenic effects which I'd avoid regardless of gender.
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Estrogenic? O_o
 
SillySlinky said:
As someone who's done well over 1000 hits of L in less than a decade or two, It's boring as shit after discovering K. I prefer IM or IV, but that's usually when using a sealed vial of Anesket which is pretty much nowhere to be found. I figure dissolving and filtering out contaminants at the bottom that don't dissolve, remeber, gotta do less than 200mg/mL because higher than that and your Ket will get saturated and precipitate out. It will no longer dissolve. A separatory funnel would be best, but work with what you can. ALWAYS use distilled water. Honestly, it's better to only inject out of a sealed vial. Also you'll want to use a micron filter to be sure.
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IM? I just do intranasal and I'm good
 
My first disso was fxe

First time did instranasnal 25 mgs and got the wonky walk, felt like face was numb

Eventually 50 mgs sub q felt really good watching a movie almost like an alcohol buzz with senses how it does

70,80, 100 imed was too much and thought that went too far as I would become what I call offline where I knew I was still there in a recliner but couldn't really move anything untill I came back online

R ketamine could be quite strong and intense esp a 130 mgs dose too much had to close my eyes, bright orange colors from YouTube channel I watched at the time and let it pass

I hear s ketamine is more celebral, and better for depression but I've also read r is better. r is more like a somewhat trip, which is somewhat true.

As far as using it for depression or changing your thoughts patterns , you could do it with chatgtp more than likely reframing things and or writing it in a journal, same with LSD or shrooms if this is something you'd prefer

Lower doses usually just make a bit dizzy and a good buzz

As far as building a permatolerance I think the key here is to take months long breaks , and don't exceed too high of a dose

If one has any addiction issues Ime , this can be easy to change your feelings fast, so if it's available, self discipline is a must. When it runs out don't buy any more for many months

Tolerance builds fast and while some people say once per week is enough, in medical settings it's used twice per week for say one month then it's scaled down to once a week then maybe once every two weeks, three weeks , then not recommended for a time being , many months
 
Innerpeace said:
I hear s ketamine is more celebral, and better for depression but I've also read r is better. r is more like a somewhat trip, which is somewhat true.
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bit high right now but isn't it the other way round?

anyway not sure I would use cerebral, it helps with anxiety when I take it might be an interesting alt to benzos, no way I could khole on it though I suspect and I've taken a lot in 1 session trying to chase a hole, less than half as much on race would have me in elf land
 
k tolerance is a pain in the ass bc it builds slow but lasts a loooong time. if ur a regular user you will eventually develop a stupid high tolerance that wont go away for a long time. a few months break can get u back to a place where you feel Something, but as far as i know theres no easy permanent fix. long breaks help and its good to manage ur use so ur tolerance doesnt keep climbing. if youre a daily user you just gotta be ok with it taking multiple grams in one sitting to feel anything, but in my experience thats far from sustainable.

its weird as fuck bc you will be feeling completely sober till you suddenly k hole. sometimes you wont even know it happened until your buddies say you were stumbling around and couldnt form a coherent sentence :derp: i was taking k in an attempt to help w my anxiety and chronic pain, but daily use just made my anxiety so much worse when i wasnt on it. being a psychedelic and dissociative it has the potential to exasperate mental issues if they arent being properly addressed

k is awesome but you gotta manage your use so you can actually enjoy it. taking a 2-6 month break will help a bit. in my experience only using 2-3 times per month in the long term is best for maintaining tolerance. breaking out of the daily habit is tough, but the first few days are by far the hardest. takes some willpower but the longer you go the easier itll be. just think about how much better itll feel after the break
 
It works partly via the same opioid receptor as morphine which will cause obvious tolerance issues (further info here). Also (R)-ketamine is a dopamine reuptake inhibitor which has it's own tolerance issues. Afaik most illicit K is a mix of R + S (esketamine = (S)-ketamine = Spravato).

I originally compiled this guide for opioids but it'll work for K also. It lists the key OTC items to reset drug tolerances. No expensive or experimental items used.
 
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