Does grapefruit juice potentiate ALL benzodiazepines?

[Mariposa]

The fact that grapefruit juice potentiates the effects of alprazolam/Xanax seems to be fairly well-known.

However, does this effect extend to other benzodiazepines as well? Specifically, diazepam?

Just curious- I did a search and the only thing I found addressed was alprazolam.

Please advise, thanks!

 

[mthree984]

Any other juices that potentiate benzo's ?

Or should I ask what exactly in grapefruit juice potentiates benzos?

 

[Negro-kitty]

Diazepam is only partially metabolized by cyp 3A4, the enzyme that mainly metabolizes alprazolam, triazolam, brotizolam and midazolam. Thus, grapefruit juice might have a mild effect on the high but I wouldn't expect anything spectacular.

 

[LucidDayDream]

sorry for the dumb question, but how well does grapefruit juice effect oxycodone ? I saw that it does something in a past post, but I haven't experienced anything grand by doing it. Do you drink the juice before or after? I definately saw it increase valium on the other hand..

 

[Negro-kitty]

Oxycodone is not known to be metabolized by cyp 3A4, the enzyme that grapefruit juice inhibits -- so no, grapefruit juice won't do anything for an oxy high.