It's not the actual combination, it's the amount that one has access to.
If you simply pace yourself, you will be fine.
A bar or two, then getting plastered is nothing too serious.
But when the memory goes to shit, you might even forget that you popped any to begin with.
Next thing you know, you lucked out because you ran out of benzos and booze just before you got to the point of no return.
Pacing is the key. It can be done, and it's not impossible. It's never impossible to be responsible.