Does Abilify dampen the effects of cocaine?

[blase deviant]

And if so, by how much about?

 

[5-HT2]

Abilify is an atypical antipsychotic, which pharmacologically targets 5-HT2 and D2 receptors. I'm not sure how it would interact with cocaine, but I think it's safe to say that it will modify the experience but won't kill it completely. However, if you're on antipsychotics, I'd strongly recommend against doing any stimulant, cocaine included.

Edit: Abilify does dampen the subjective effects of ampehetamine in humans. However, no human studies have looked at how it modifies the subjective effects of cocaine. It also appears to decrease relapsing to cocaine in both schizophrenic humans and rats. In rats, it did not alter cocaine self-administration, so it appears that most of the pleasurable effects were still there.

 

[EN21]

Dopamine antagonists and cocaine

Dampening the effects of coke is an interesting thing. D1 antagonists were thought to do that job, and might help to recover from addiction. Interestingly in a study with 10 habituated crack smokers, which were premedicated with ecopipam, the D1/D5 antagonist, they reported stronger effects of the crack, and also a increased desire to repeat the drug intake.
So the effect was the exact opposite to what was expected.
Funny, -isn’t it?

 

[rashandreflex]

abilify is complicated because in addition to antagonizing dopamine, it is also a partial dopamine agonist (the theory being that it will treat schizophrenia according to the revised dopamine hypothesis of schizophrenia (too much dopamine in some places in the brain cause positive symptoms and not enough dopamine in other areas causes negative symtpoms)...i don't really know if this works in practice...that is, by what mechanism does the abilify "decide" where to agonize versus antagonize dopamine?) i guess, then, it may have the potential to increase the pleasurable effects of cocaine, in theory.

however, my answer to this question is the same as every time someone asks about mixing stimulants and antipsychotics: just don't do it. stimulants seem to fuck with people's stability very badly (seems to be the worst offender among all drugs classes, imo) and if you're in need of abilify, you'll be better off avoiding recreational stimulants.

 

[Dr. Beat]

Dampening the effects of coke is an interesting thing. D1 antagonists were thought to do that job, and might help to recover from addiction. Interestingly in a study with 10 habituated crack smokers, which were premedicated with ecopipam, the D1/D5 antagonist, they reported stronger effects of the crack, and also a increased desire to repeat the drug intake.
So the effect was the exact opposite to what was expected.
Funny, -isn’t it?

dopamine hitting D1 receptors (and glutamate hitting NMDA receptors) causes your brain to adapt to the drug, so blocking either D1 or NMDA receptors is great for stopping your tolerance going up.

D2 receptor seems to give most of the euphoria, although D1 has some euphoric effects as well.

 

[scream]

Risperdal kills the effects of methylphenidate. I can take 10 Ritalin tabs and feel nothing on 2-4mgs Risperdal, d2-blockage?

I hate dopamine blockers, unless, i MUST sleep/rest.