It is theorized that MDMA in some way stimulates the brain's vasopressin system. Vasopressin is believed to be heavily involved with the way our brains experience romantic love: the chemical induces feelings of trust and empathy, and brain scans have shown the vasopressin system to be especially active when a subject is interacting with a romantic partner. If these theories are true, then in a sense, MDMA makes you fall in love with the entire world, and allows you to open yourself up to it in the same way you would to an old lover.
Now as to your question, the answer is "sort of." Drugs of another class (i.e. not MDx/bk-MDx) can also make you feel less ashamed and more open, but they not really in the same way. Some drugs in the class of GABA agonists (e.g. alcohol, GHB/GBL, benzo's) may produce similar effects by reducing the user's mental inhibitions. Other drugs, as mentioned above, can simply produce enough euphoria that the user no longer feels the anxiety which causes shame and closedness.
Now as to your question, the answer is "sort of." Drugs of another class (i.e. not MDx/bk-MDx) can also make you feel less ashamed and more open, but they not really in the same way. Some drugs in the class of GABA agonists (e.g. alcohol, GHB/GBL, benzo's) may produce similar effects by reducing the user's mental inhibitions. Other drugs, as mentioned above, can simply produce enough euphoria that the user no longer feels the anxiety which causes shame and closedness.