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Opioids do opioids work under the tongue?

Yes, though I would never put Vicodin or percocet under my tongue as they are huge pills full of fillers and nasty Acetomeniphen.

However, some opiates are wasted pretty much, on oral/sublingual administration, such as heroin. Oxy and hydrocodone do have good oral BA, so they should do well sublingually as well.
 
I can't imagine holding a pill the size of percocet, let alone vicodin, under my tongue. Actually I remember one time I needed to take some percocet and didn't have anything to swallow it with, I tried and failed to dry swallow it so I just held it under my tongue until the disgusting taste got to me and I pulled over and got a drink at the gas station. Never again will I attempt to sublingual compounded opiates.

I take OxyContin sublingually though
 
Yes, all ROA's go through the liver.

I would expect a much longer onset than orally, considering your sublingual mucous membranes are trying to get past at least 325mg tylenol and who knows how much filler, to get to a meager 5-10mg of opiate.

It's really going to disappoint you, I recommend taking the pills orally as prescribed/intended.
 
tricomb said:
Yes, all ROA's go through the liver.

I would expect a much longer onset than orally, considering your sublingual mucous membranes are trying to get past at least 325mg tylenol and who knows how much filler, to get to a meager 5-10mg of opiate.

It's really going to disappoint you, I recommend taking the pills orally as prescribed/intended.
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what about oxy 30s "rocos,blues" under the tounge? How does that compare to oral and snorting?
 
Sure you can take a Roxi 30 sublingually, but there's no point to it. Snorting will give you a faster onset--better rush, and anything that doesn't get absorbed in your nose you can wash into your stomach by snorting some water. Swallowing a crushed up pill on an empty stomach will hit you the same as SL, and its is much easier, less time consuming. If you want, try it out and just be sure to swallow your spit when your done, its not as though the drug will be negatively effected by the enzymes or ph of your spit (I've looked into it :) )
 
I think opiates don't generally absorb well enough sublingually to make it a useful route when dealing with oral pills. Pure substances or sublingual formulations will work well though.

Sublingual admin does bypass first-pass metabolism largely, though you are undoubtedly swallowing some of the drug in most cases.
 
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waldo777 said:
Sure you can take a Roxi 30 sublingually, but there's no point to it. Snorting will give you a faster onset--better rush, and anything that doesn't get absorbed in your nose you can wash into your stomach by snorting some water. Swallowing a crushed up pill on an empty stomach will hit you the same as SL, and its is much easier, less time consuming. If you want, try it out and just be sure to swallow your spit when your done, its not as though the drug will be negatively effected by the enzymes or ph of your spit (I've looked into it :) )
Click to expand...

Where is this rush everyone keeps talking about? even IV oxycodone doesn't have a rush, just immediate onset. I've been using OC for years and have never experienced a rush.
 
^ A rush is just the drug setting in. I prefer the feeling of a drug setting in through insuffulation more than any other route, IV included, because the way it sets in is just perfect. IV and smoking are too instant for my liking, and oral admin requires a fairly large dose to really feel the setting in phase.
 
^ I think that the only criteria for a rush is that it is an intense setting in phase, so they're really the same thing, just one is stronger.
 
Onset of action is the length of time needed for a medicine to become effective. A rush is the intensely pleasurable sensation experienced immediately upon a drug entering the bloodstream.
 
I don't know... even IV oxycodone isn't something I'd call "intense" just a rapid change of state to intoxication.

edit: yea, by tripmans definition, oxycodone produces no rush, there is no intense euphoria/pleasure.
 
Tripman said:
Onset of action is the length of time needed for a medicine to become effective. A rush is the intensely pleasurable sensation experienced immediately upon a drug entering the bloodstream.
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I didn't say onset of action though, I said the feeling of the drug setting in. You go from sober to not sober by a sensation, and a rush is a type of this sensation. Anyway, I wasn't really trying to argue about this, just pointing out that people look for different sensations when taking drugs (because really, isn't the the feeling of it kicking in what we are really going after?)
 
It's not an argument, it's scholarly discussion :P

I just don't think that going from sober to not sober constitutes a rush.

And yes, the onset of the opiate is one of the best parts, but I'd have to say I prefer peaking :)
 
I like the opiate high. The rush is a bonus, but it seems like the more people experience it, the more they begin to prioritize it over the high itself. I hope that doesn't happen for me, because chasing a rush requires a lot more effort than a traditional 2 - 6 hour high.

I find this semantic discussion a bit difficult to wrap my head around. I've never IVed oxy, but maybe the reason it doesn't have "rush" is because it's a prodrug? Heroin and hydromorphone can go straight through the BBB without needing the body to alter it.
 
Oxycodone isn't a prodrug, unless you're talking about the tiny amount of oxymorphone it's metabolized into. But Oxycodone is active all on it's own, and makes up for the majority of it's analgesic properties. The Oxymorphone is responsible for only around 10% of it's effects.
 
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