Opioids Do Opiate Potentiators Allow You To Take Less Opiods Without Getting Withdrawals?

[love_sex_desire]

I've heard of a number of opiate/opiod potentiators that vary in their usefulness depending on what king of opiates you are using and how you are using them ranging from grapefruit juice (only when dosing orally?), small amounts of ketamine, small amounts of DXM, benzos etc.

Even though many things potentiate the high of opiates would any of these potentiators allow you to take less of an opiod without feeling withdrawals?

For example if someone was prescribed a 100 mcg/hour fentanyl patch to wear transdermally for 72 hours, are there any potentiators that could be taken on a regular basis that would allow the person prescribed a 100 mcg/hour fentanyl patch to use the potentiators and a 75 mcg/hour fentanyl patch without feeling withdrawals?

I have been intrigued by the idea of opiate potentiators, I just always wondered if any of these potentiators would allow someone to lower their regular opiod dose without feeling side effetcs.

Any experience or thoughts?

Thanks

 

[Cane2theLeft]

It depends on a lot of factors and what type of potentiators... if its like CYP450 inhibitors that actually raise the plasma levels of the drugs, then yes.

If its something like a benzo that just adds to the 'high' (or depending on the issue, could reduce the pain, etc. with the pain reliever) then it won't stop the withdrawal if you're on a low enough dose to cause withdrawal but it will alleviate some of the symptoms.

In pain management they aim to prescribe medicine so people can take lower amounts of opioids and call these opioid sparing agents... NSAIDs, benzos, muscle relaxers, anticonvulsants, etc... some of those "potentiate" the high (or really have synergy) and others only help the pain relief, muscle relaxation, etc.

 

[love_sex_desire]

So would grapefruit which I believe is a CYP450 enzyme inhibitor allow someone who is using fentanyl to use less without noticing withdrawals if they drink large amounts of grapefruit daily?

What other CYP450 inhibitors are there?

What other options and potentiators are there for someone to use less opiates and not feel withdrawals?

And does grapefruit and other CYP450 inhibition work with all routes of administration? I thought it was only if used orally, but it seems trnasdermal use is also potentiated. What about buccal administration of strips of fentanyl?

My friend sometimes cuts up pieces of fentanyl and puts it under his tongue with the sticky side down or he places it between his gum and his mouth with the sticky side facing his mouth. Wonder what the options of potentiators will allow him to use less fentanyl withot getting withdrawals.

Thanks

 

[hydrochron]

Well weed potinates hydrocodone, I don't know about other opiates. But I was able to feel hydrocodone by smoking and taking 1.5mgs of xanax. Which is funny sense it usually wouldn't work really. But smoking is scientificaly proven to increase hydrocodones effects. Ill chime in more later on my computer. Is there a specific opiod in question?

Search opiate potenation thread.

 

[Cane2theLeft]

So would grapefruit which I believe is a CYP450 enzyme inhibitor allow someone who is using fentanyl to use less without noticing withdrawals if they drink large amounts of grapefruit daily?

What other CYP450 inhibitors are there?

What other options and potentiators are there for someone to use less opiates and not feel withdrawals?

And does grapefruit and other CYP450 inhibition work with all routes of administration? I thought it was only if used orally, but it seems trnasdermal use is also potentiated. What about buccal administration of strips of fentanyl?

My friend sometimes cuts up pieces of fentanyl and puts it under his tongue with the sticky side down or he places it between his gum and his mouth with the sticky side facing his mouth. Wonder what the options of potentiators will allow him to use less fentanyl withot getting withdrawals.

Thanks

The potentiation will work for any ROA, not just orally because it happens through the metabolism of the drugs in the liver.

I think you are overestimating the potentiation that CYP450 inhibition can produce... many people don't feel it at all and those that do, have slight to moderate potentiation. Its not as if you could take an opioid dose low enough that it wouldn't hold you and add GFJ or tagamet and then get high. It can boost/lengthen the effects a small amount but not THAT substantially.

The poster above me is right, this discussion should be directed to the opiate potentiation mega thread that I believe is on the front page currently.

If not you can easily find it through the directory alongside many other useful posts sorted by topic and by mega thread.

Hope that helps.