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do drugs hit you harder in the morning?

I have found if I have a cone within say about 30 minutes to an hour after waking up I get really sick and everything and dizzy... I really don't like smoking in the morning that much.
 
in my experience, it's definitely not an effect of time increased time between use. for example, recently i took a rather large dose of xanax one night. i woke up the next morning and took a smaller dose of klonopin thinking it wouldn't effect me much because of the xanax i had taken the night before and it would probably be a waste but surprisingly, i got very strong effects from it.
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In this case you likely experienced stronger effects because you had primed or loaded your body from the night before. Benzos don't have that 'rush.' (the wonderful powerful come on you get with amphetamines and opiates and even soma, I'm not talking about a real 'rush' but it seems like a decent enough term since they both describe the same phenomenon, although they seem to lack that as well) You had preloaded your body with a drug and it's metabolites and were able to experience and effect as strong or stronger than you would have expected from the post-load dose.

This sort of thing is very commonly experienced with GABAergics, especially the long acting ones, but only because their long half lives enable it to be experienced over a long period of time, though for drug users using frequently, it'd be seen just as easily with short-acting benzos.

another example is when i took 2 somas one morning, i got so messed up i couldn't even sit up in a chair and it was actually unpleasant and i havent wanted to take soma ever since, when i was usually fine doing it at night.
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Soma is a difficult drug to make any comment about. It's effects can be very unpredictable. I've noticed that use after any drug that messes around with dopamine has the potential to make Soma into an uncomfortable experience. Paradoxical agitation is commonly seen with the drug, even with frequent use, and no alteration in dose, akathasia while heavily sedated can suddenly present itself. So can heavy sedation, though that is reported less frequently, likely because that's the side effect that everyone is expecting.
 
mushi mushi 88 said:
I have found if I have a cone within say about 30 minutes to an hour after waking up I get really sick and everything and dizzy... I really don't like smoking in the morning that much.
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THC is really the only drug that doesn't fit well with what I described. Here the time between last and first dose doesn't have much or any impact on the increased morning effects.

It's always baffled me.
 
Drugs hit me harder when I'm tired. I'm usually tired and I have a completely empty stomach in the morning. I think that's the simple explanation.
 
if i'm IV'ing, makes no difference. but if i take my diazepam in the morning as soon as i wake up (even as little a does as 15-20mg, for me) i have to have a quick nanny nap when it hits for bout 20-30mins for some reason or a big fuckload of coffee.

my bupe, when i abuse it, hits me the same as it would any other time, same as tramadol if i switch back to it. sometimes i notice a bigger hit if i've eaten something before the tramadol rather than an empty stomach
 
Yes, absolutely. With a good cup of coffee and my pain meds, after about 45 mins. my pain and stiffness is gone from the night before and I am ready to take on the day. As long as I slept reasonably well and for more than 3 hours anyway. I do think it has alot to do with the rest as well as the empty stomach thing.
 
Yeah i would also say for us who are in chronic pain ... nothing in the world feels as good as those morning pills .. only thing that sucks is the pain in the morning .
 
well im suppose to take 20mg 4x daily oxycontin , normally take a 20 and 5/325 in the morning . but i was taking 2 20's in the morning because the 20s have slowed in duration and effect . came back down because i got started to feel bad about double dosing .
 
i believe with consuming 20mg 4x a day, that is a relatively amangeable tolerance to use fentanyl with. do not fuck around with the fent though...
hard to abuse.
 
Well i dont abuse any of the pills im prescribed with anyway .. which im pretty proud of considering i love the feeling opiates give .. i just remember that what my doctor is doing for me is a big favor and dont want to fuck it up.

but anyway back to the topic on hand .
 
Theres nothing like waking up to the first ciggerate and then the traditional wake n bake. I always get a lot higher when i wake up smoke a blunt then go amongst my day as normal. Its great. :)
 
Did 2ml of GBL 1st thing in the morning the other day and it blew my head off.

I was rushing harder than if I was on MDMA, it lasted about an hour and then for the next hour and a half I was all floaty and content and NICE.

amazing experience, but 1 which is abit too nice if you get what I mean.
 
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