DMTy

[haribo1]

Just wondered, if you make dimethyl tryptophan, will it decarboxylate when heated. If so, it would make an excellent prodrug. It occurs naturally in some plants so you can just extract (if your in Australia).

 

[Helios.]

Yes.

 

[yoyoman]

ya know.. i've heard this mentioned, a coupel other times - even Dr. Shulgin mentions it..

anybody know?

 

[haribo1]

Well, I don't think it would fall under any CsA laws since in itself its a prodrug therefore legal everywhere. Exhaustive methylation with methyl iodide then dequaternisation would make it from tryptophan.

 

[fastandbulbous]

The plant source I looked at also contained a rather nasty protein poison, so be careful in what you're doing

 

[Jamshyd]

Just out of curiousity, how would one go about decarboxylating this assuming one has it extracted?

I'm not asking for a synth, simply wondering what the process is?

 

[haribo1]

Well, I'm HOPING that it would thermally decompose upon smoking

 

[Helios.]

Jamshyd,

<whisper from cyberspacetime... repeated>

reflux in turpentine

 

[EN21]

The monomethyl congener is called abrine and it is woefully toxic!
I wouldn't try stuff like that!

 

[haribo1]

Well some sources don't have abrine in them.

 

[yoyoman]

I've seen this mentioned a couple times on other boards - chemistry boards etc..

As a possible legal alternative to DMT if it works.. (at least i'm pretty sure this was the one mentioned)

(synthetically made etc)

 

[haribo1]

^^^If you could find a reference, that would be much appreciated. If this works, then DMTy for all. I made 5MeO-DMT when that was legal, I see no difficulties here.

 

[vecktor]

abrin confusion

confusing the two abrins is common:
historically abrine and abrin have been used in a limited way as a name for NN-dimethyl tryptophan, and possibly NNN trimethyltryptophan which is also believed to occur in abrus precatorius seeds. unfortunately abrin has also been used to refer to the lectin abrin which is a rather toxic protein totally unrelated to tryptophan.
I vaguely remember NNN trimethyltryptophan being toxic but nowhere near as toxic as the lectin abrin.
I doubt that NN dimethyltryptophan will thermally decarboxylate by smoking in significant amounts, though it may well be decarboxylated by tryptophan decarboxylase to DMT in the body. however it is unlikely to be active as DMT needs either a MAOI or rapid administration to overwhelm MAO in order for useful amounts to press the synaptic buttons. tryptophan decarboxylase is a rare enzyme and it isn't going to produce DMT faster then the common and rapid acting Mono Amine Oxidase chews it up.

 

[haribo1]

tryptophan decarboxylase ay... well, diethyl tryptophan would seem the logical alternative then?

 

[Coolio]

What about dimethyl tryptophan + a traditional MAOI like ayahuasca?

 

[haribo1]

^^^Now THAT is a good idea!