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DMT + Mushroom Tolerance

Mate i have never taken shrooms but i have taken a bit of DMT and nothing will build a tolerance to it, go forth my friend 40mg will break you thru, as for smoking ive only ever vaporized it, good luck :)
 
For the smoking 'The Machine' seems the most popular, you can find instructions how to make one really easily.
That failing, yes you can sandwich the dmt in weed and a regular lighter will suffice.

As for tolerance. You shouldn't have an issue.
Mushrooms work primarily on the 5H2A receptors while I believe that DMT's main site of action are the sigma receptors (correct me if im wrong anyone), so there won't be any cross tolerance.

It also sounds like you haven't smoked DMT before, in which case I wouldn't aim for a breakthrough straight away, work your way up (you can dose multiple times in a day if you so desire). Nothing I have experienced comes on as quickly or as intensely as a high dose of DMT.
 
DMT doesn't seem as susceptible to tolerance as other psychedelics. Don't think anyone has a good handle on why though. DMT does have affinity at one or a couple sigma receptors, but in terms of activity, I don't know of any good data on what that means.
 
I found DMT to be very susceptible to tolerance, but only when used repeatedly in a very short space of time. After a few days without use I found it would go away but if used multiple times daily tolerance would rocket upwards. I recall doing 100mg and having little to no effects, after a binge. Then a day or so later 30-40mg would be mind blowing again. That's very odd if it's just me. I wouldn't imagine a weeks break after doing some mushrooms would have any effect on tolerance of DMT.

The way I smoke it before was to place DMT on tin foil and place a pint glass on top of it, using an elastic band to hold it in place. Heating the tin foil until it was all smoke in the glass then using an emptied out pen or tube to pierce the tin foil and suck it all in. The benefit of this being the smoke has a little time to cool first as the first time I did it in my friends glass vape pipe he heated it way too much and I burnt my throat really badly. Also found just chasing it off tin foil meant if it got too close to the edge the vapours would occasionally explode into flame which isn't nice right next to your face, and its wasteful.

As one of the above posters mentioned be careful with DMT if its your first time, its quite and experience and it comes on very quickly. I remember a friend ask me and another friend if he could try DMT. We said yes and tried our best to explain the experience as best we could so he would know what to expect. We did however forget to mention it hits you immediately, which lead to an experience he enjoyed but definitely scared him a little. The first thing he said was "oh no". Maybe a little irresponsible on our part.

Anyway be careful dude.
 
Psychedelics tend to produce a strong tolerance, but dmt is the exception to this. You would notice no tolerance is this situation.
 
Disconnect said:
For the smoking 'The Machine' seems the most popular, you can find instructions how to make one really easily.
That failing, yes you can sandwich the dmt in weed and a regular lighter will suffice.

As for tolerance. You shouldn't have an issue.
Mushrooms work primarily on the 5H2A receptors while I believe that DMT's main site of action are the sigma receptors (correct me if im wrong anyone), so there won't be any cross tolerance.

It also sounds like you haven't smoked DMT before, in which case I wouldn't aim for a breakthrough straight away, work your way up (you can dose multiple times in a day if you so desire). Nothing I have experienced comes on as quickly or as intensely as a high dose of DMT.
Click to expand...

I'm pretty sure the significant effects of DMT are mediated more by 5ht receptors than sigma receptors, but I can't cite any references for that.

Either way though, you'll be fine. Psychedelic tolerance tends to dispel within a weak, and DMT particularly tends not to be affected as much by tolerance as other psychedelics, for whatever reason.
 
Except for oral DMT - I find that has a stronger tolerance than even mushrooms. Try using oral DMT twice in a week and the second time is a shadow of the first.
 
Thats not case IME with ayahuasca when I take it two days in a row. Don't know if you let more days pass.
 
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