Pharmacology dl-methamphetamine as nootropic

[Leprechaun]

I’ve found the taboo and social negativity to methamphetamine fascinating.

Have done some anecdotal experiments with low dose, up to 30mg over 24 hrs in a similar pattern to what Alexander Shulgin described in his pharmacology notebooks.

The experience is nice, however excessively long lasting.

But what I found even more interesting, after researching, there are studies show nootropic and neuroprotective effects of meth amphetmine in low doses.

I could never understand how someone would take high doses, back 7-10 and even 20 years ago, whenever I took anything near 100mg I had an extremely negative experience. And I read of people injecting 100mg in one shot… which just blows me away as to why such a high doses?

Anyway, here are the studies, which as always show, the dose makes the poison.

The neuroprotective potential of low-dose methamphetamine in preclinical models of stroke and traumatic brain injury

Methamphetamine is a psychostimulant that was initially synthesized in 1920. Since then it has been used to treat attention deficit hyperactive disord…

www.sciencedirect.com

Long-Term Treatment with Low Doses of Methamphetamine Promotes Neuronal Differentiation and Strengthens Long-Term Potentiation of Glutamatergic Synapses onto Dentate Granule Neurons - PMC

Methamphetamine (METH) is a psychostimulant, affecting hippocampal function with disparate cognitive effects, which depends on the dose and time of administration, ranging from improvement to impairment of memory. Importantly, in the United States, ...

pmc.ncbi.nlm.nih.gov

 

[Stephy]

I’ve found the taboo and social negativity to methamphetamine fascinating.

Have done some anecdotal experiments with low dose, up to 30mg over 24 hrs in a similar pattern to what Alexander Shulgin described in his pharmacology notebooks.

The experience is nice, however excessively long lasting.

But what I found even more interesting, after researching, there are studies show nootropic and neuroprotective effects of meth amphetmine in low doses.

I could never understand how someone would take high doses, back 7-10 and even 20 years ago, whenever I took anything near 100mg I had an extremely negative experience. And I read of people injecting 100mg in one shot… which just blows me away as to why such a high doses?

Anyway, here are the studies, which as always show, the dose makes the poison.

The neuroprotective potential of low-dose methamphetamine in preclinical models of stroke and traumatic brain injury

Methamphetamine is a psychostimulant that was initially synthesized in 1920. Since then it has been used to treat attention deficit hyperactive disord…

www.sciencedirect.com

Long-Term Treatment with Low Doses of Methamphetamine Promotes Neuronal Differentiation and Strengthens Long-Term Potentiation of Glutamatergic Synapses onto Dentate Granule Neurons - PMC

Methamphetamine (METH) is a psychostimulant, affecting hippocampal function with disparate cognitive effects, which depends on the dose and time of administration, ranging from improvement to impairment of memory. Importantly, in the United States, ...

pmc.ncbi.nlm.nih.gov

What is nootropic? I know I could Google it but it's more fun to conversate with you

 

[Leprechaun]

What is nootropic? I know I could Google it but it's more fun to conversate with you

Nootropics are generally not really acutely psychic compounds, but work in the body to shield you from stressors.

Ie, a 150mcg dose of LSD has clear acute psychic effects.

A nootropic generally does not. It is generally used chronically over a certain period of time during stressful or high work to reduce impact of the stress on the mind and body.

For me, I find the best nootropic all round is Phenylpiracetam.

The above studies show that chronic low dose and single dose effects reduce the effects of stress on the brain.

 

[Allylbenzene]

What is nootropic?

You could interpret nootropics as pro-metabolic substances which act either directly or indirectly by removing metabolic blocks.

By pro-metabolic I imply supporting mitochondria, thyroid and liver function (liver makes T3) which results in boosting ATP, CO2, T3 and all hormones with protective & regenerative roles (pregnenolone, progesterone, DHEA, testosterone etc).

On CO2's important physiological role, it's not "just a waste gas".

Considering the universal importance of carbon dioxide to life, the ways it interacts with all of the important substances that make up organisms, that it is involved closely with ATP synthesis and other “energy-related” processes, that it participates intimately in the regulation of water and ions, that it is therapeutic in a range of conditions including angina pectoris, hypoxia, epilepsy, inflammation, shock, lipid peroxidation, pneumonia, and asthma, I think we can at least conclude that it is a largely overlooked mediator between chemical energy and life processes. In many cases, its movements and reactions constitute the actual motive force that so many fantasy theories have failed to explain. In other situations, it fills out the context for understanding the energy-mediating actions of ATP, calcium, and hormones.

For me, I find the best nootropic all round is Phenylpiracetam.

All dopaminergic-type drugs have pro-metabolic nootropic-type effects.

Recently, it was discovered that both S-phenylpiracetam (MRZ-9546) and R-phenylpiracetam (MRZ-9547) inhibit dopamine (DA) uptake and reuptake and that R-phenylpiracetam is more active than S-phenylpiracetam.

- https://doi.org/10.1016/j.pbb.2017.07.009

 

[Dextro .45]

Desoxyn (d-Desoxyephedrine HCL) Methamphetamine is prescribed in 5mg tablets as I’m sure you’re aware of. Adult dose is 5-25mg daily …I heard it is amazing compared to Adderall, Dexedrine, etc

It’s far less twenty they said, almost a calming stimulant due to its prominent Serotonin properties…this guys Desoxyn script was $2,000.00 USD but paid $5 dispensing fee

Id love to try legit Desoxyn 5mg tablets

In low therapeutic doses, I’m sure it great…..peaople who abuse Methamphetamine It’s a neurotoxic drug, killing off dopamine, and other monoamines

Racemic Meth would be harder cardiovascularly…..d-Methamphetamine (Desoxyn) would be my Nootropic drug of choice, but I personally would add some Oxycodone, Valium & Xanax, all low dose of coarse