diphenhydramine for ketamine comedown?

[randmanq]

Hello everybody. I've tried to do some searching but I couldn't find specifics for my question so I figured I'd come here. I take diphenhydramine every day to sleep, about 250mg. Would that same dose be fine to take after one has used ketamine? Probably like two hours after or so. I'm not suggesting a straight combo of the two, but separated by a few hours. Or would there be health concerns with doing this?

Thank you smart people

 

[randmanq]

I don't really understand what you mean there. I'm just curious about whether I should skip my usual routine of taking diphenhydramine before sleep if I have used ketamine a few hours prior

 

[nAON]

250mg DPH is a massive dose, why are you taking so much?

 

[randmanq]

Tolerance I suppose, it doesn't feel overly strong to me. I did not start with that dose, just eventually worked my way up. Would that kind of dose be bad with ketamine in my system?

 

[randmanq]

Mind you I only took one line of the ketamine

 

[laCster]

there wont be any interaction between ketamine and DPH. hydroxyzine/ketamine is commonly combined in anesthesiology, but 250mg dph is alot, you will experience some anticholonergic effects which might be untolerable.

i have a high tolerance to sedative anti-histamines, DPH, promethazine, hydroxyzine, ect.., and i still dont like to push 150mg in one dose. i'd start off with 100-150mg. and add another 25-75mg depending on how you feel.

 

[hatrix]

Comedown ? I really find dissociatives as having just about no comedown...

This seems silly to me. Sounds like an excuse just to take something else. I doubt it will have any real benefit.

 

[Venrak]

^ The OP wants to know if it is safe to take their normal nightly dose of diphenydramine on the tail end of a ketamine experience.

Yes, you're okay OP.