Opioids Dilaudid Plugging vs Insufflation

[papaown]

~Sorry for the graphic details, but they're needed haha.~

Hey everyone, I plugged a 4mg Dilaudid this morning (bowels completely evacuated). Put the plunger in as far as possible, then laid on my side for 30 minutes. Felt a very slight buzz, nothing great whatsoever. The feeling was relative to no more than popping 30mg of morphine IR (hardly any mood lift, very very slight body high).

I read up a bit on plugging, considering it's hardly ever worked for me, and found out that plugging should be a much more preferred ROA than snorting, so I tried it again about an hour ago out of frustration. This time, instead of putting the plunger in all of the way, I did what a member suggested and put the plunger only about an inch in, and pulled the plunger. Once again, I waited 30 minutes on my side to no avail. Very light high, if any at all.

Out of curiosity, I took another 4mg dilaudid no more than 20 minutes ago, dissolved it in luke warm water, and slowly dripped it into my nose as my neck is hanging off the bed and at an angle. I got the intranasal technique from a thread here. I did this so the liquid would stay in my nose without dripping down my throat. After about 5 minutes I felt great. SOOO much better than plugging the hydromorphone

Anyone else had this experience? Plugging just seems to not work for me, no matter what drug it is. The BA of Hydromorphone seems like it would be immensely stronger plugging, but intranasal in a water suspension seems to be MASSIVELY more effective for me and I'm puzzled by it.

Thanks for your input

 

[papaown]

I'm surprised no one else has had this experience like mine. I guess I'll just stick to insufflation until I can figure out why plugging isn't working for me.

 

[Tryptamino]

snorting hydromorphone has a higher bioavailability. I'm not sure the exact numbers, but i'm pretty sure insufflation is about twice as strong, but i could be wrong. I've only snorted dilaudid and IV'd it though, so I can't really speak with that much certainty on the subject.

 

[sekio]

Some drugs aren't absorbed well rectally even though they work great nasally, ketamine is one of them. And of course, everyone is different when it comes to drug absorbtion.

Rectal administration of hydromorphone has been evaluated in healthy adults and found to have low bioavailability (33%) with wide interindividual variation

The average BA of nasal is about 55-60%, which again is variable. And nasal will produce higher peak concentrations than oral doses by a factor of almost fourfold.

 

[papaown]

Some drugs aren't absorbed well rectally even though they work great nasally, ketamine is one of them. And of course, everyone is different when it comes to drug absorbtion.


The average BA of nasal is about 55-60%, which again is variable. And nasal will produce higher peak concentrations than oral doses by a factor of almost fourfold.

That would make tons of sense, but I'm unbelievably confused because I've seen almost 20 different threads all talking about how plugging hydromorphone is supposed to be superior to snorting.

 

[Eva 33]

My pain doctor prescribes hydromorphone 3 mg. suppositories for me, and they are very effective at relieving my severe pain. The only route of administration for hydromorphone that is stronger would be IM injection, and finally IV injection.

I've never snorted pills, so I can't help you there. I just wanted to state that hydromorphone can be absorbed rectally very well, in the form of a suppository. I have no idea if that ROA works with pills, though.