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  • N&PD Moderators: Skorpio

Dihydroetorphine

Yeah, but what has shown that these are non-addictive? If they're mu1 agonists, I don't see how it's possible, even if they're insanely potent.

Are there any self-administration studies?
 
I'd be suspicious of any research claiming that dihydroetorphine is non-addictive as such, especially in a patent application where they'll really be wanting to exaggerate the difference between the claimed drug and previous work in the field.

Animal studies show that DHE is self-administered which suggests some abuse potential. However it does seem to be less addictive than most opioids, and slower to develop tolerance too, and that coupled with its high potency make it unsurprising that the Chinese have adopted it as an analgesic and for opioid substitute treatment.

Sounds like an interesting drug at any rate, wonder how it compares to buprenorphine seeing as they're pretty closely related. DHE is a full agonist and much more potent than bupe, but if its less addictive and produces less tolerance than most mu full agonists there must be something special about it.
 
haribo1 said:
Here is a nice link explaining that DHE is non-addictive. If so, wouldn't that be a boon to addicts? I know Chinese users who inject DHE to stop them hangin out.

http://www.wipo.int/pctdb/en/wo.jsp?WO=1994%2F06426&IA=WO1994%2F06426&DISPLAY=DESC
Click to expand...

Well here's a line I've copied & pasted from the article...


Preferably the replacement opioid is methadone administered per os at a dose of about 5-100 g/day.
Click to expand...

Bet they run out of patients pretty quickly! =D
 
Wow, those chinese must love downing cherry syrup, or do you suppose they administer it as one massive suppository? ;)
 
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