different effects from different types of amphetamine doseing

[allthegoodjwh's]

Is it better to take one larger dose of amphetamine and have as much hit the bloodstream as possible or Is it better to take smaller doses throughout the day for example I used to take vyvance and found it has very powerful effects which I hypothosis Is because of the lysine molocule causeing dexamp to be constantly released into the bloodstream at a slow rate

I currently take dexedrine spansules and it has a half instant release and half delayed release very simmilar to vyvance (not just an instant second dose) bit a constant slow release
And i found that the first part of the dexedrine was fairly weak but later in the day I noticed effects a lot stronger almost on par with vyvance

I know in higher doses amphetamine inhibits Mao a and b
and it Also causes vmat2 inhibition (vía taar1 agonizim)

I know that a dri for example cocaine when administrered before amphetamine
causes a severe reduction of effects as amphetamine cannot induce reversal if the dopamine nueron/cell Is already blocked


I dont know of amphetamine dose 1 would prevent amphetamine dose 2 from working (it has a different mechanisim of dri effects than Standard dri's so i dont know id it would or not

To resum my question to anyone thats confused I tend to organize and phrase posts badly
In basically asking Is it better to have a massive dose of amphetamine hit the blood stream at once

Or smaller controlled doses throught the day

And by most effective I dont mean euphoric effects I mean focus mood lift and energy and Long duration of action preferably at least 8 hours of good effects
(In on 30mg 2x day)
If Its better to have 1 (maybe 2) larger ir doses eg 20-25mg
Or focus on maintaining the xr doses
I work Long shifts in a demanding job and goto college
So i need to be attentative and i need the slight mood lift or I may snap from the bullshit
And I like it to be as strong and Long lasting as possible because I have day Long work then college or vice versa
I deffinatly feel like theres a difference between the two dosing options and it would be awsome if someone had the science to explain what Goes on behind the scenes between the two
comedown if any isnt an issue i have lyrica and seraquel which even adderall zr couldnt touch
anyways thank you in advance

 

[DynoSpec]

if you want it to last longer xr is the way to go. the crash is going to be worse from ir because its straight up and down, where as with xr you will have a fairly steady blood plasma level.

its different for everyone, but i know that for example when i dose meth orally a couple times in a night the comedown is much much worse than smoking it throughout the night. cocaine use before amps should not mess with the buzz much, if anything it will be stronger as amps/meth allow more dopamine in, while not letting it out so to speak. it probably just seems shitty because the coke comedown is still sorta there.

if you need to be ready to rock and focused i think taking a combo xr/ir dose in the am and a second ir dose halfway through your day would be effective. be careful though its really easy to end up doing massive amounts after a while, and either having lots of difficulty stopping or just never stopping.

 

[allthegoodjwh's]

The thing Is I have no problem stopping in just simply not capable of working my job well enough and retaining knowledge from studying (too unable to focus) I actually dont take it at all on my days off at all to combat tolerance
The onlu thing Is I noticed if you take a large dose it last a Long time like longer than a smaller xr dose

For example like 60mg ir damp
Will outlasy a 30xr easilly
technically it should produce more intence effects for roughly half as Long
but instead it goes many hours longer
I wonder. Why that is
like maoi activity ect ect

 

[DynoSpec]

a 60mg dose is going to last alot longer than 30 because theres more drug. 30xr is still working and doing its thing just it wont feel so because you have a tolerance. I used to take 50-100mg of xr addy each day for a few months when i was working 2 jobs and finishing high school, and it definitely worked the whole time. try to take the same dose at the same time each day maybe rather than a fat one one day and only a little another. taking magnesium and lowering your stomachs ph before dosing can help duration aswell. avoid vit c until you are ready for bed.

 

[allthegoodjwh's]

I assume the vitamin c Is because it turns dopamine into to norephinephrine and would reduce effects even further?

 

[Venrak]

Just take what brings the desired effects, of course within reason. I would often start off a session with maybe 60% more than my redose usually was. Redosing is eventually only going to lead to bad territory if it's kept up, though.