Differences between naturally occuring and completely synthetic psychedelics?

[RhythmSpring]

Don't forget, you guys, that with synthetic psychs you're almost always taking ONE single chemical. With taking natural psychs, like mushrooms, peyote or ayahuasca, you're ingesting many chemicals, many of them active in certain ways.

So in a way, the differences might have more to do with the level of complexity in which you are altering your system.