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Opioids Did you know MENTHOL is a k-opioid agonist?

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King J

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Wow,

I looked on Wikipedia and Menthol is a weak k-opioid agonist. But suppose in large doses in mint leaves could help you from withdrawing from the major mu and u opioid agonists and analgesics, such as Morphine, Heroin, and Oxycodone etc.

The only k-opioid pill I know of is Tapentadol, brand name Nucynta.

But I bet you if you were able to get some mint leaves and make a tea, perhaps several times a day, you could get clean. I read a lot that if you do k-opioid receptor when you're withdrawing from the other receptors it reverses the balances and reduces tolerance.

I don't think menthol based chewing gum (spearmint etc flavors) or menthol cigarettes actually have any menthol in them, but menthol is from all mint leaves so I would definitely want to try it out actually. Seems like a cool way to get off the H and the M and the roxies.
 
Average cough drops have like 3mg menthol. Extra strength ones have like 8.5mg.
 
Menthol does have a slightly "bingey" effect on me, in that when I start with menthol cough drops, I keep sucking on them, on and on, in ridiculous amounts. And when I stop, my throat feels not so good, so I keep taking them. There is something slightly addictive about menthol even in cough drops IMO, very slightly, but still.
 
Menthol is not centrally active as a strong KOR agonist like salvinorin is.

Kappa oioid agonism is reponsible for the dysphoria and hallucinogenic effects of some of the benzomorphan opioids. It's not strictly a good or pleasant effect. Also, KOR agonism doesn't stop the bad effects of my- or delta- opioid withdrawal does.

Sorry dude.
 
sekio said:
Menthol is not centrally active as a strong KOR agonist like salvinorin is.

Kappa oioid agonism is reponsible for the dysphoria and hallucinogenic effects of some of the benzomorphan opioids. It's not strictly a good or pleasant effect. Also, KOR agonism doesn't stop the bad effects of my- or delta- opioid withdrawal does.

Sorry dude.
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WRONG. Those are only LEGAL k-opioid herbs and crap that you're talking about produce hallucinations and psychological effects.

Look at the drug Nucynta, is now a Schedule 2 full k-opioid agonist that is for pain and is a narcotic. I'm pretty sure that Tramadol is also a k-opioid receptionist binder.

Furthermore, even the legal herbs will prevent withdrawal and help because you're still affecting the receptors, no matter what opioid receptors they are, in your intestine, in your blood-brain barrier, or your entire central nervous system. It's typically the CNS kind that are controlled aside from a secret select few along with Kratom. ;)
 
buprenorphine is a k-opioid antagonist and is part of the reason you can get anti depressant effects from it.. in high AGONISM of the k receptor sekio is correct.

ive got 50g pure menthol crystals.. no recreational effects. i have tried.
 
King J said:
WRONG. Those are only LEGAL k-opioid herbs and crap that you're talking about produce hallucinations and psychological effects.

Look at the drug Nucynta, is now a Schedule 2 full k-opioid agonist that is for pain and is a narcotic. I'm pretty sure that Tramadol is also a k-opioid receptionist binder.

Furthermore, even the legal herbs will prevent withdrawal and help because you're still affecting the receptors, no matter what opioid receptors they are, in your intestine, in your blood-brain barrier, or your entire central nervous system. It's typically the CNS kind that are controlled aside from a secret select few along with Kratom. ;)
Click to expand...

You're extremely mixed up. Nucynta is a dual MOR agonist and NRI, it has nothing to do with KOR. Tramadol is a SSRI and its active metabolite is a NRI and MOR agonist. Kappa activation decreases dopamine release and opposes many actions of the MOR. Its dysphoric and it won't attenuate mu opoid withdrawals. In fact, it will probably make it worse. Menthol is a very weak KOR agonist.
 
Tramadol, bupe, and Nucynta are moderate KOR agonists at best. They are not nearly as dysphoric or hallucinogenic as strong KOR agonists.

Menthol is a weak KOR agonist at best. Another way of thinking about this is the relative potencies of drugs at the mu opioid receptor, codeine is weak, oxycodone and morphine fairly strong, fentanyl very strong. Just because a drug has activity doesn't mean it produces strong effects.
 
Alex000 said:
Menthol does have a slightly "bingey" effect on me, in that when I start with menthol cough drops, I keep sucking on them, on and on, in ridiculous amounts. And when I stop, my throat feels not so good, so I keep taking them. There is something slightly addictive about menthol even in cough drops IMO, very slightly, but still.
Click to expand...
I would go through bags of those as a teenager. A friend always made fun of me for being "addicted" to them.
 
Menthol is tasty and delicious (if cold), but I don't think it is a centrally active KOR agonis in the same manner as salvinorin. I've yet to hear of a mint trip, maaaaaaaan.

Do note that menthol interferes with nicotine's metabolism and prolongs the nicotine high, as seen with mentholated cigarettes. Curiously, African-American seem to be the dominant users of menthols. Wonder why?
 
That's why we have citations on wikipedia - links to external, verifiable sources. This prevents people posting "Richard Nixon had a 14 inch turgid penis " on wiki and having it become fact. If you can't cite a source, it gets cut from the wiki.

"Wikipedia is editable by anyone and shouldn't be trusted" isn't a valid argument in this day and age. use your critical thinking skills, bruv.
 
King J said:
WRONG. Those are only LEGAL k-opioid herbs and crap that you're talking about produce hallucinations and psychological effects.

Look at the drug Nucynta, is now a Schedule 2 full k-opioid agonist that is for pain and is a narcotic. I'm pretty sure that Tramadol is also a k-opioid receptionist binder.

Furthermore, even the legal herbs will prevent withdrawal and help because you're still affecting the receptors, no matter what opioid receptors they are, in your intestine, in your blood-brain barrier, or your entire central nervous system. It's typically the CNS kind that are controlled aside from a secret select few along with Kratom. ;)
Click to expand...

Actually youre wrong. Just because something is an opioid receptor agonist doesnt mean it will cross the blood-brain-barrier. Look at Immodium (loperamide), that shit is an actual opioid and doesnt relieve withdrawals or fuck you up at all no matter how much you take, so even if menthol did act on a receptor, it wouldnt do shit.
 
Wesley_pipes_27 said:
Almost all the opiate user in my neck of the woods smoke menthols. It just does something to up that high just a little bit. Love em.

WP
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Yes. I'm not even sure of anyone that does any opiates that smokes NON menthol cigarettes right after a line. ;) Of course, everyone WITH menthol cigarettes tend to smoke more while on dope or pills.

Salvia is for the most part a weak K-opioid receptor binder. Salvia B in it is the strong part but there's barely anything of that. And course all of you are comparing it to trippy k-opioid drugs it's ridiculous. The k-opioid does relief pain as well..and get you high. It's not a psychedelic thing.

I would love to make some menthol tea or smoke menthol or just something to test it out. I know it's weak by itself but could that be testing ONE leaf? The leaves are quite small. Actually when I was 11 or 12, my first cigarette was a hand-made rolly of my friend's ma's mint leaf garden. Rolled a couple leaves up and smoked it. :D

Again though I would honestly like to test it.
 
like i posted already i believe.. i have 50g pure menthol crystals and i have tried numerous times in the past to get high some way off it but never got anything outta it.
Everyone is different though.
And just to note.. i am a menthol smoker lol

EDIT: and i just want to note because it looks like my other post has been overlooked.. buprenorphine (suboxone, subutex) is a k-opioid ANTAGONIST not agonist like menthol.. it is what helps bupe be sort of like an antidepressant, if it was an agonist than once you pass a certain dose you will get dysphoric and trip and shit.. not fun times mmkay.
 
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