Opioids Did we ever discern how much Loperamide is needed to cross the BBB??

[ChemicallyEnhanced]

Someone recently posted a study that showed some evidence that Omeprazole can also help it cross the BBB.

I happen to be prescribed Omeprazole (just to take "as needed", not every day)....so if I took say two pills (40mg) of that and 24mg Lope...would that be enough?

Do we have ANY idea how much is needed?

 

[ChemicallyEnhanced]

I'll take that as a "no"?

 

[N1GHTMAR313]

Someone recently posted a study that showed some evidence that Omeprazole can also help it cross the BBB.

I happen to be prescribed Omeprazole (just to take "as needed", not every day)....so if I took say two pills (40mg) of that and 24mg Lope...would that be enough?

Do we have ANY idea how much is needed?

Well tbh I just usually drank a half a bottle or ate 12x2 mg tablets. But I wasn't seeking a buzz, I was seeking withdrawal relief without Suboxone or Subutex for fear of precip. That amount, 24 mg, provided enough relief to stop the hellish, unholy, restless legs and allowed some sleep.

 

[ChemicallyEnhanced]

Well tbh I just usually drank a half a bottle or ate 12x2 mg tablets. But I wasn't seeking a buzz, I was seeking withdrawal relief without Suboxone or Subutex for fear of precip. That amount, 24 mg, provided enough relief to stop the hellish, unholy, restless legs and allowed some sleep.

Yeah, I took 18 pills (so 36mg) yesterday and definitely wasn't high, but any withdrawal I had was very mild (I had my last actual opioids Monday evening).
I'm sick now, but still not as bad as I should be almost 48 hours [Wed 5:15 pm here] with no morphine. Normally 36 hours had me with uncontrollable vomiting and diarrhea and that hellish thing were EVERY muscle aches and hurts and your BONES ache and yes the leg thing, where you need to move them CONSTANTLY.

16 hours til I get my pills *sigh*

EDIT: Cool, I managed a nap (yen sleep?) and now it's a little over 12.