Hello everybody
I was tapering a lot and i stayed on 400mg tramadol plus 240mg dihydrocodeine.
It was ok but now i do not have 60mg DHC tabs, instead i have 20mg Oxycodone long-acting Targin tablets...
I take 2 of these oxy every once in a while but i can't get rid of impression that tramadol + dhc was superior to tramadol plus Oxycodone....
20mg oxy (PO) = 30-35mg morphine (PO)
Morphine is 10x stronger than codeine.
If i ingest 5mg morphine, it should be close to 60mg codeine. But according to the low BA of morphine, 5mg eaten is 1,5mg active. If i eat 60mg codeine, isn't it converted to 10-15% morphine, so 6-9mg active morphine ?
DHC is twice as strong as codeine but it has 25% BA. So from 60mg prolonged release tablet only 15mg dhc is active ? Then how i can't feel 20mg oxy prolonged release with almost 90% BA and much higher opioid binding than dhc, even if i eat more of them at once ? I take maybe 100mg tramadol daily less, and oxy is proper from pharmacy. Do i have to just...let my body adjust to different opioid ? Or why i do not feel much stronger effects ?
I was tapering a lot and i stayed on 400mg tramadol plus 240mg dihydrocodeine.
It was ok but now i do not have 60mg DHC tabs, instead i have 20mg Oxycodone long-acting Targin tablets...
I take 2 of these oxy every once in a while but i can't get rid of impression that tramadol + dhc was superior to tramadol plus Oxycodone....
20mg oxy (PO) = 30-35mg morphine (PO)
Morphine is 10x stronger than codeine.
If i ingest 5mg morphine, it should be close to 60mg codeine. But according to the low BA of morphine, 5mg eaten is 1,5mg active. If i eat 60mg codeine, isn't it converted to 10-15% morphine, so 6-9mg active morphine ?
DHC is twice as strong as codeine but it has 25% BA. So from 60mg prolonged release tablet only 15mg dhc is active ? Then how i can't feel 20mg oxy prolonged release with almost 90% BA and much higher opioid binding than dhc, even if i eat more of them at once ? I take maybe 100mg tramadol daily less, and oxy is proper from pharmacy. Do i have to just...let my body adjust to different opioid ? Or why i do not feel much stronger effects ?