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Stimulants dextroamphetamine tolerance

inept enigma

inept enigma

Bluelighter
Joined
Jan 30, 2004
Messages
57
Location
South-East United States
i went through the cycle of ADHD meds about 5 years ago (from concerta, to adderall xr, to adderall ir, to dextrostat[dextroamphetamine instant release] which i stayed with). i would binge the 2 to 3 days after getting the script (like maybe 4-5 10mgs a day for 3 days) then take it as prescribed (or not at all and sold it). i stopped taking it after quitting college and i have only taken ANY kind of stimulant (coke/ice) on VERY RARE occasions since then. now, i restarted college this year and got a new shrink to start writing me again. right off the bat i took 3 10mg dextrostats and ahrdly felt anything (other then peripheral effects such as teeth grinding, sweating and of course increased focusing) but basically NO EUPHORIA! the next day i took 60mg at once and felt a twinge of euphoria, but back 5 years ago, that high of a dosage wpould have had me rushing, the "tingles" as i call the,m and just feeling great, but now all i do is sweat, grind my teeth and do nothing but write poetry, draw and read, which is nice and all, but WHERE WENT THE EUPHORIA? i have heard aftyer extended, long-term usage, your dopamine cells stop producing and (from what i've read) it is permanent. but my queastion is this, why, after not using (for all practical purposes) and stimulants in 5 years would i go from relatively strong euphoria at moderate dosage to basically NO euphoria, even at very high doses? can anyone help me out here? i worked for 2 months, went to 2 shrinks and have no insurance so i spent hundreds of dollars to get these things back and now i get 180 10mg dextrostats a month and they're worth basically jack-shit to me. any ideas from you pharmacology/speed-freaks?
 
I think your issue here is mindset, really. After experiencing a high from coke or ice, dextroamphetamine's euphoric value could seem fairly tame.
 
son of a bitch! i even tried using baking soda as a potentiator, and NOTHING. i read a lot before doing this and everyone was absolutely PRAISING it and saying "be careful! you might OD! take only 1/3 your normal dose!" i took basically my normal dosage (i'm prescribed 60mg a day [20mg 3x/day]) i just take it all at once in the morning cuz it seems to last pretty much all day anyways. not posting just to bitch, i'm just wondering "what's up?!" haven't taken any amphetmaines in 5 years til last month and 5 years ago i never needed more than 20-25mg to be in HEAVEN, but i moved and stopped taking it. hell, i had a whole script bottle in my drawer for 4 months before i took it all so it's not like i've been on this stuff for 10yrs or even 2 yrs, it's been 2 MONTHS and b4 that 5 YEARS. are my dopamine receptors shot to hell and FUBAR? i've tried 5-HTP as well and "nada". please someone gimme some ideas here, i'm confused as hell. timeline:

6:30am: 15mL sodium bicarbonate (baking soda)
6:45am: 50mg dextroamphetamine sulfate (dextrostat) [oral]
7:45am: 15mL sodium bicarbonate (baking soda)
8:00am: feeling on a mild amphetamine buzz (like i took 25mg or so) i'll wait awhile, but so far am very disappointed.
9:30am: 30mg dextroamphetamine sulfate (dextrostat) [oral/sublingual]
12:30pm: have alot of energy but NO euphoria, NO tingles NO "floaty" feeling, just wide awake, moderate concentration increase w/ some of the negative peripheral effects (slight paranoia, hyperreflexia, diarrhea)
 
first time i plugged was the same thing ecxept it was 30mg adderall daily that wasnt even making me focus. then plugging the same amount that would eat got me twice, if not more than what oral administration would do even with baking soda. otherwise you could take the gamble and try and get your doc to give you desoxyn
 
@OP, I don't understand. Is this use recreational? Amphetamines aren't very recreational IMO, even d-amp, the price you pay in side effects for minimal euphoria isn't worth it.
 
tricomb said:
@OP, I don't understand. Is this use recreational? Amphetamines aren't very recreational IMO, even d-amp, the price you pay in side effects for minimal euphoria isn't worth it.
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i've experienced euphoria second only to desoxyn on d-amp, theyre pretty euphoric
 
tricomb said:
It's probably just a matter of preference, but even with crystal methamp, the euphoria isn't as good, or "clean" as opiates for me.
Click to expand...

apples and oranges

@OP, i strongly suggest you try plugging the same dose as you take orally. it will vastly improve your focus.
 
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I've only done d-amps and Concerta (such a waste of money). D-amps are great for the effects you wrote off; the focus and motivation is actually my favorite thing about it but anything that can give me that and euphoria is a Godsend. The thing is that the molecule is so complicated it takes a really long time for your body to break it down (thus being a pro-drug compared to Adderal since it can't be snorted or IV'd). I've only had euphoria twice though, the first time I took 60mg of Vyvanse and right now from 60mg of Vyvanse again, which has been like almost a month since the last time I took them (but the euphoria seemed much shorter lived this time around, it only lasted maybe three hours then I crashed physically but mentally still pretty high; the energy just kind of turned into lethargy). I've done it like two or three other times at the same dosage but mostly those gave no euphoria and little to no increased attention/motivation which I expect may be just my tolerance kicking in very quickly. I think it might be that d-amps just aren't are potent as normal speed unless you take like 120mg (which I do not suggest; that's quite a lot with you're recent reintroduction into them).

My suggest would be to try and mooch some Adderal off one of your friends (or you could buy it or trade some of your v's?). See if you get a normal high off of those at a baseline tolerance dosage for trying to get high, I've never done straight amp so I can't really help with the dosage but I assume it'd be a much easier way to gauge whether or not amps still affect you like you remember doing them rather than by taking a much more complicated chemical. If not, the second poster may be right in guessing that your experience with other stimulants has made you expect more and d-amps just don't give a hugely euphoric high especially at 60mg, the euphoria isn't very strong even when other effects are very strong; broxism or toothgrinding (I'm pretty sure I've messed up most of the tissue on my bottom lip and my togue feels burnt or something like I chewed on it when I wasn't noticing today), energy, focus/motivation, twitchyness, etc.
 
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gingervitus said:
I've only done d-amps and Concerta (such a waste of money). D-amps are great for the effects you wrote off; the focus and motivation is actually my favorite thing about it but anything that can give me that and euphoria is a Godsend. The thing is that the molecule is so complicated it takes a really long time for your body to break it down (thus being a pro-drug compared to Adderal since it can't be snorted or IV'd). I've only had euphoria twice though, the first time I took 60mg of Vyvanse and right about now from 60mg of Vyvanse (but the euphoria seemed much shorter lived this time around, it only lasted maybe three hours then I crashed physically but mentally still pretty high; the energy just kind of turned into lethargy). I've done it like two or three other times at the same dosage but mostly those gave no euphoria and little to no increased attention/motivation which I expect may be just my tolerance kicking in very quickly. I think it might be that d-amps just aren't are potent as normal speed unless you take like 120mg (which I do not suggest; that's quite a lot with you're recent reintroduction into them).

My suggest would be to try and mooch some Adderal off one of your friends (or you could buy it or trade some of your v's?). See if you get a normal high off of those at a baseline tolerance dosage for trying to get high, I've never done straight amp so I can't really help with the dosage but I assume it'd be a much easier way to gauge whether or not amps still affect you much than by taking a much more complicated chemical. If not, the second poster may be right in guessing that your experience with other stimulants has made you expect more and d-amps just don't give a hugely euphoric high, the euphoria isn't very strong even when other effects are very strong; broxism or toothgrinding (I'm pretty sure I've messed up most of the tissue on my bottom lip and my togue feels burnt or something today), energy, focus/motivation, twitchyness, etc.
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The op is talking about d-amphetamine. vyvanse is not d-amphetamine, it's lisdexamfetamine, which gets converted into dextro into your stomach and releases it VERY slowly into your liver. ive never even gotten a buzz off that, so im surprised you ever even got any euphoria at all.
 
Bigfanofthemdrugs said:
The op is talking about d-amphetamine. vyvanse is not d-amphetamine, it's lisdexamfetamine, which gets converted into dextro into your stomach and releases it VERY slowly into your liver. ive never even gotten a buzz off that, so im surprised you ever even got any euphoria at all.
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Oops, my bad. I'm pretty new. Sorry, nevermind then lol
 
my psychiatrist is def. cool in my book, but for any non-drug user w/ any knowledge of pharms theywould say he's a str8 up bat-shit crazy quack w/ a phd in both psy. and philosophy. i tell this man what to write for me. i asked for 30mg a day and he says thats too low and gives me 60mg. also, he says to be at the optimal/correct dosage, you should have NO appetite @ ALL. told him usually id eat a banana or cereal bar on dextrostat and he says that shows i was on too low a dose! never asked for desoxyn but the crazy SOB really might consider it. when i asked for the dextrostat, he said he only writes it too one other patient but that whatever works for me is good. also he said my current 180 count 20mg 3x/day is a low-to-moderate dose and if it doesn't seem to be enough, he will increase it! is it just me or is this crazy(although no argument from me, just considering everyday joe-blow taking 20mg 3x/day, they'd be in a psych ward in a week) oh yeah, he himself is on adderall he says (i believe 30mg XRs). only shrink i ever had that talk more than me as well as butt-in and finish my sentences while he sits perched in his office chair looking like he's a shortstop ready to field a grounder, lol. the man is a genius academically ( magna cum laude michigan st in both psychiatry and philosophy + all sorts of awards) but DAMN, he acts like hed give me 40mg 3x/day if i asked and gave a half-assed reason.

i hadn't tried dextrostat b4 asking for the script, only adderall, ritalin, concerta, but had been told by numerous druggies (bluelighters included)it was far superior to adderall because of there being no l-amph. maybe i should ask for adderall, but i remember the crashes being horrid (the 1st time i ever took it @ 15 i didn't know the strength it had and was given a whole bottle of 60 30mg IRs). well, i had started shooting k4s that year, so i thought i was a badass and needed 5x what anyone else took so i took 2 right off the bat and as you can guess 45min. later i was feeling like god herself so i pop 3 more. long story short, ended up seeing a "bump" on my lower lip and picked it so hard for so long, my bottom gum literally sagged so far down you could see my veins on the inside. i honestly thought i would be scarrecd forever but the doctors healed it. needless to say, i got to add "amphetamine psychosis" to my list of experiences.

anyways, i HATE ritalin and if i had focalin id shoot em all up in 2 days (more amph. psychosis) and the only other alternatives are adderall and desoxyn. guess i'll find out how twack out my doc really is. they prescribe it for adhd on any kind of half-ass regular basis? i mean is it like seeing a broken arm person get 8mg dilaudid? or should i just opt for a huge dosage of adderall (ex. 30mg 3x/day) and YES he WOULD do that, so (1) is my doctor completely shot-the-hell-out or are these acceptable dosages, (2) is asking your adhd doc for desoxyn like givng yourself the stamp of "dope fiend" on your forehead and (3) would taking adderall be any different or make any difference tolerance/euphoria-wise than taking these ungodly large doses of dextroamphetamine i've tried (up to 120mg in a day)?

thanks for tolerating the ramble guys, its the only thing taking 150mg d-amph today has done. thanks
 
PDR says max dose of d-amph is 60mg, that's what i have now so i can halfway understand that, but the shit about not eating to be on the proper dosage and saying hed increase my 180 10mg dextrostat script almosts made my jaw drop. but its n my favor, so fuck it, just concerned about little 10yr old johnny coming home w/ mommy and his brand new medicine mommy says he needs to take 2 of these little orange pills with a "b" on them 3 times a day to help him study.l...jesus christ, man. i pretty much determined he had some issues when he said that about not eating (along w/ a strong affinity for amphetaminies. u should have heard him praisng them, saying i'd get all As, help my depression and anxiety. basically told me to take em and id get a phd, love the world, love myself plus have any hot girl come give me head by just taking another pill and asking her to!) but i really need to know and am curious about how crazy is asking my doc for methamphetamine already being on 60mg d-amph/day and how rare getting it for adhd truly is and the adderall question.
 
I have nothing good to say about a psychiatrist who will not warn a patient of the negative effects.

Enlargement of heart, necrosis of cardiac tissue, dopamine down regulation, hypertension leading to vast organ damage, malnutrition, irritability and insomnia

Amphetamines are a double edged sword 100% of the time by themselves; unless one takes multiple supplements and drugs alongside them, but then it becomes the story of the "Old Lady Who Swallowed the Fly" in that one will always need something to counteract the negative effects of another substance.
 
We can't help you procure prescriptions from your doctors. If you aren't satisfied with 60mg dexedrine, frankly, there are no stimulants that can please you. Certainly not adderall, and I doubt desoxyn would even be enough for you. 60mg dexedrine will have DIRE consequences.
 
I've heard of a guy getting prescribed 200mg of IR Adderall a day, I shit you not. To doctors, the PDR is just a "guideline" and every person's brain is wired differently, which is true to an extent, but let's be real, usually anything more than 30mg daily is abuse, most ADD adults only need about 10-15mg a day, 20mg max.

You need to ask yourself why you're taking these medications. Is to increase focus to a normal level (use), or to boost productivity so you can get shit done (abuse)?

A very small percentage of people need more than 30mg, but this is usually due to CYP2D6 polymorphism, which I suspect I have, since I get serious opioid activity from Tramadol's O-Des conversion (50mg tramadol is far stronger than 10mg hydrocodone for me). I still make do on 15mg max Dexedrine a day, though, but I've taken 17.5mg in a day a couple of times without realizing.
 
Yeah the PDR only says the recommended maximum value, I used to be prescribed insane doses of dexedrine, like 80mg+ and desoxyn, I used to be prescribed 100mg/day on schooldays, 80mg/day weekends (i know my psychiatrist is.... liberal to say the least), Taking 25mg QID (four times daily) desoxyn but now I take less than 20mg whenever I dose, and I try to dose maybe once a week, if that.

And my alprazolam? I'm managed to tell my doctor I tapered down to 12mg/day with as many PRN doses as I need. I barely take benzos at all anymore.

Okay im wayyy too tired to still be awake. Night guys
 
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