Dextroamphetamine (Dexedrine,Vyvanse) vs Wellbutrin (Bupropion) for DEPRESSION!

[MMMMKAY?!]

I know that wellbutrin is an antideppressant that works on norepinephrine and dopamine-as does dextroamphetamine.
I would think dex would be better for depression in some ways just because it is much stronger than bupropion.
But I was just curious seeing as how bupropion is the one thats actually classified as an antideppressant and is used much more for depression, which one IYE/IYO do you guys think is better for depression.

P.S. I did not add adderall because the crash isn't even worth the initial antideppressing effects and it makes me act quite 'awkward'

 

[Crashing]

I don't know, getting high on stims, even dextroamp, doesn't seem like a great way to treat a problem. It's not that much different than adderall, and I would expect a serious rebound effects to occur upon cessation.

Bupropion is much easier to manage. I mean, heroin is fucking great for depression too but it's not the best choice for obvious reasons.

 

[Swimmingdancer]

My doctor thinks bupropion is better than dextroamphetamine because it is more subtle. Stronger isn't necessarily better, it also equals more side effects, faster build of tolerance, more potential for addiction, etc.

 

[MMMMKAY?!]

I don't know, getting high on stims, even dextroamp, doesn't seem like a great way to treat a problem. It's not that much different than adderall, and I would expect a serious rebound effects to occur upon cessation.

Bupropion is much easier to manage. I mean, heroin is fucking great for depression too but it's not the best choice for obvious reasons.

I really wasn't in any way intending to imply or suggest that I was trying to get "high" off the D-amp...
I was simply stating that while bupropion has a more mild effect on norepinephrine and dopamine-which are two chemicals that many psychologists believe contribute somewhat to depression-and d-amp has more of an affect on them, then wouldn't you think technically it would be better for depression..? Of course I know though that the stronger the medication, the worse side effects it will have. I really wasn't in any way shape or form trying to ask anything about recreational drug use and if it came across as that, then I didn't mean for it to.

 

[Crashing]

Sorry i was just being facetious. But the point being, the drug is used to get high because it is capable of being used that way. The side effects of using d-amp daily include depression, amongst a slew of other things, and therefore I don't think it would be better. Stronger isn't better in some cases, as this is probably one of them.

 

[MMMMKAY?!]

Sorry i was just being facetious. But the point being, the drug is used to get high because it is capable of being used that way. The side effects of using d-amp daily include depression, amongst a slew of other things, and therefore I don't think it would be better. Stronger isn't better in some cases, as this is probably one of them.

Its all good. I understand what your saying and where your coming from though. your probally right/

 

[pasha]

While dextroamphetamine may provide you with temporary relief from depression, the side effects it carries will not allow you to treat your depression in a sustainable fashion. As your tolerance grows so will the dose, and the side effects will inevitably increase. Another thing to keep in mind is even though amphetamines are prescribed off-label for depression, many users tend to develop depression after chronic long term use. If you suspect dopamine to be the cause of your depression, I would recommend bupropion.

You take mixed-salts-amphetamine (Adderall) for your ADHD, since your asking this question I would assume that you think dextroamphetamine would be able to tackle to your depression were Adderall couldn't, but I don't think it would make much a difference.

 

[MMMMKAY?!]

While dextroamphetamine may provide you with temporary relief from depression, the side effects it carries will not allow you to treat your depression in a sustainable fashion. As your tolerance grows so will the dose, and the side effects will inevitably increase. Another thing to keep in mind is even though amphetamines are prescribed off-label for depression, many users tend to develop depression after chronic long term use. If you suspect dopamine to be the cause of your depression, I would recommend bupropion.

thank you very much [:. this is a well put answer.

 

[Praline]

I do really well on wellbutrin..The only this is I get antsy after a few weeks of of so I have to cycle it..
I do even better on speed, but like they said above, it's fairly unsustainable. So I save it for once a month or something.

 

[MMMMKAY?!]

really? does it give you that motivated feeling? they just switched me from addys to dex and the dex is much cleaner but it lacks that motivated feeling that adderall gave me

 

[DonMakaveli]

I would say, for depression, Wellbutrin. First cuz SSRIs are more commonly prescribed for depression than add/adhd stimulants are & second, the crash associated with dextroamphetamine, or even uncomfortable side effects that can come at low doses, add more to depression n worsen it IMO.

Just my $.02

 

[MMMMKAY?!]

I would say, for depression, Wellbutrin. First cuz SSRIs are more commonly prescribed for depression than add/adhd stimulants are & second, the crash associated with dextroamphetamine, or even uncomfortable side effects that can come at low doses, add more to depression n worsen it IMO.

Just my $.02

hell yea, i think your right about it causing more depression in the long run. I gotta really weird psych n I should probally change. last time I saw him i was on 30mg adderall xr in the morning and 10mg at noon. I had just come back from a "placement" and he said "thats all?" and I said yea that I thought that was alot and i'm trying to get off them for good in the long run. I suggested doing dexedrine because of it being much less intense (IMO at least), I suggested 15mxr morning and 15mg xr noon. He said that that was too little and he rather do 30mg xr morning , 15mg ir noon, and 15mg ir around 4pm /:. I didnt decline. He also put me on 1mg tenex twice a day for anxiety. To me its almost like he's trying to keep me 'dependent'.. doesn't 60mg a day sound a lil high? N' its not like i'm big or anything I'm a pretty short dude. (120-125lbs)

 

[pasha]

doesn't 60mg a day sound a lil high?

It all depends on your tolerance really more-so than your weight. In Canada the maximum you can get prescribed is double that so it's not really outrageous. How's the Guanfacine fairing in terms of depression and music appreciation? Make sure you never take more amphetamine than prescribed as when you become dependent on the guanfacine, taking too high a dose amphetamine could cancel the effects of the guanfacine and send you into hypertensive crisis.

 

[MMMMKAY?!]

It all depends on your tolerance really more-so than your weight. In Canada the maximum you can get prescribed is double that so it's not really outrageous. How's the Guanfacine fairing in terms of depression and music appreciation? Make sure you never take more amphetamine than prescribed as when you become dependent on the guanfacine, taking too high a dose amphetamine could cancel the effects of the guanfacine and send you into hypertensive crisis.

I haven't been taking it much but I took it last night during a shroom trip, then this morning cuz it was my first day back at the university (for anxiety) I feel extremely depressed today. Idk what it is. But its bad. Also it was really hard to stay awake in class but I got a suprisingly good ammount of sleep (for me) last night. About 7 to 8 hrs. I just wish I still had that motivated feeling I had a while back..

 

[Swimmingdancer]

I would say, for depression, Wellbutrin. First cuz SSRIs are more commonly prescribed for depression than add/adhd stimulants are & second, the crash associated with dextroamphetamine, or even uncomfortable side effects that can come at low doses, add more to depression n worsen it IMO.

Just my $.02

Wellbutrin is not an SSRI. It's an atypical antidepressant that works mainly by norepinephrine and dopamine reuptake inhibition. So it's kind of like an amphetamine as far as the neurotransmitters it affects (and even in its molecular structure) and actually works well for people with ADHD. It's just much gentler than taking amphetamines and more sustainable for long-term treatment of depression and just generally a wiser choice for depression for the reasons I and others have mentioned above.

hell yea, i think your right about it causing more depression in the long run. I gotta really weird psych n I should probally change. last time I saw him i was on 30mg adderall xr in the morning and 10mg at noon. I had just come back from a "placement" and he said "thats all?" and I said yea that I thought that was alot and i'm trying to get off them for good in the long run. I suggested doing dexedrine because of it being much less intense (IMO at least), I suggested 15mxr morning and 15mg xr noon. He said that that was too little and he rather do 30mg xr morning , 15mg ir noon, and 15mg ir around 4pm /:. I didnt decline. He also put me on 1mg tenex twice a day for anxiety. To me its almost like he's trying to keep me 'dependent'.. doesn't 60mg a day sound a lil high? N' its not like i'm big or anything I'm a pretty short dude. (120-125lbs)

As Chromophobia said, it really depends on tolerance and the person, but if you weren't complaining about the dexedrine not doing anything it does seem odd that he would immediately encourage you to take a higher dose.

 

[MMMMKAY?!]

update on my current situation (also I thak you guys greatly for the advice it rlly duz help): I had asked my doc for the noon and 4pm to be changed to IR. He told me he was busy but he could do that. I drove to his office at the local UBH and whe I got there he told me that instead of 15 noon 15 4pm to just do 20 noon and 20 4pm...wtf. like, I wanted to decline but I kinda felt like if I did he wouldn't really prescribe me stuff anymore. It was weird..idk how I should tell him that I'm trying to get less medicated..? My goal is to stick with something like wellbutrin, buspar, nuerontin ( for nueropathy), diphenhydramie (for sleep, or somethig similar but not strong), maybe a lil dexedrine \:. Maybe I should switch doctors..? Cuz you gotta admit it seems weird how he does things. But I'm also kinda scared if I change drs they wot prescribe what I want like I know he will

 

[Treefa]

I tried wellbutrin for like 7 days...made me snap at people.

It was pretty much opiate rage minus the high, and lots of twitching.

 

[MMMMKAY?!]

How did it make you feel in terms of motivation?
And a question to everybody: is there a med that boosts norepinephrine (besides adderall) that could maybe be added with my dexedrine to get that motivated feeling back-don't get me wrong I prefer dexedrie over adderall anyday, but adderall did make me very productive.
What about straterra?

 

[Midazle]

I don't know, getting high on stims, even dextroamp, doesn't seem like a great way to treat a problem. It's not that much different than adderall, and I would expect a serious rebound effects to occur upon cessation.

Bupropion is much easier to manage. I mean, heroin is fucking great for depression too but it's not the best choice for obvious reasons.

Sorry i was just being facetious. But the point being, the drug is used to get high because it is capable of being used that way. The side effects of using d-amp daily include depression, amongst a slew of other things, and therefore I don't think it would be better. Stronger isn't better in some cases, as this is probably one of them.

Replying to both of your posts. Good stuff, your well informed and on the ball BUT I will play devils advocate a tad here and there. Yeah Adderall is used for refractory depression with success also concerta has the purpose as well...results are very mixed though and I've seen kids with depression loose it on the crash...I was on Focalin XR and I remember going to my school nurse and telling her I was feeling out of my mind...I had to get some benzos from home and then passed the f out! I'd say you need a near constant dose 24/7 if you use amphetamines* for depression but obviously thats going to effect sleep...however I did test this theory out with myself by taking 30mg of Adderall XR during the day and 10mg of Adderall XR towards the evening when I would do homework for a little bit and then sports and made sure my dose was timed so it would go well into my sleeping hours..Obviously to sleep I had to relax and take some benzos so I took Ativan and Ambien (I was prescribed both)...I noticed that doing this for a week or so my focus was much more consistent and I didn't really crash at all or get depressive symptoms, my dreams became extremely vivid with more instances of VERY scary nightmares but again the benzos kept that under control to a certain extent. Overall it was interesting but it required a moderately high dose of benzos and ambien and I wasn't looking to become overly dependent on various substances. I ended up trying Wellbutrin with no Adderall and noticed it helped a tad with mood but not that much.


As for opioids for depression...yeah that is never a 1st, 2nd, or 3rd, hell I wouldn't consider it 4th line for depression! BUT Their are some studies about Oxymorphone for depression, I think its a rather interesting topic. Problem is opioids are so addictive and someone who is depressed is more likely to take more and more Oxymorphone if its working VERY well. I know my first experience with Oxycodone was amazing...I had crushed my hand and was in severe pain, I was prescribed Hydrocodone but 10mg wasn't cutting it and my doctors knew that, I screwed the bone and nerves up real bad so I was put on Roxicodone 10mg. I took it and the euphoria was absurdly pleasurable, my mood was lifted from the dumps to high heaven! Anyways for 1 month I took it as my hand healed up and then for another month I only suffered minor pain and took 5mg 2x or 3x a day and my mood was perfect, I didn't feel the need to up the dose despite having a tolerance. I also had chronic pain since I was very young and because of my age doctors would only give me Vicodin with really bad flares, but I talked to a girl in my science class who had a severe injury at a young age and also suffered from severe depression, she was on OxyContin and it appeared to really make her happy, she was only 20's twice a day and from her account never felt the need to increase past that, apart from being mildy moody sometimes she did well in school...one day in class a kid asked her for some OxyContin and she said "No that stuff is like my antidepressants" which is what sparked my interest in the topic. I think something like Opana ER 5mg or 10mg in a 24hour dose would be interesting for severe depression not responding to a SSRI/SNRI/Stimulant/etc in patients not posing a significant risk of suicide would be interesting of course monitoring for abuse would be needed and just a pain in the rear for anyone but the most passionate research doctor. Other opioids like Tramadol, methorphan, tapentadol, and levorphanol show similar if not great potential if you really look into their actions. If a chemist could design an opioid that could attach to the subrecepters that induce euphoria and the anti depressive effect only I think it would be revolutionary...problem is with opioids you get all the effects or none for the most part and trying to only get certain effects has been a chase for a LONG time hence why we have semi-synthetics and synthetics that have less side effects but never ONLY the intended effects.

Sorry for the wall of text...just took some adderall for the first time in like 2 months to clean my room...lol


(*when I refer to amphetamines I refer to both amphetamines and substances like [Dex]methylphenidate as well)

 

[laCster]

I'd never want to take amphetamine daily, that would suck. If you are looking for an anti depressant go with wellbutrin. Buproprion has stimulation similar to amps, but more subtle and has less side effects usually....

For me wellbutrin causes more side effects than vyvanse. So idk....