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Dextro-theanine

pubmed.ncbi.nlm.nih.gov

Pharmacokinetics of theanine enantiomers in rats - PubMed

Theanine, first discovered in tea, is a chiral nonproteinic amino acid that has been reported to have cardiovascular, neurological, and oncological effects. It is being considered as a therapeutic/medicinal agent and additive in consumer products. The present study evaluated the pharmacokinetics...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov


The D-enantiomer appears to have been studied to some degree in animals and humans. Lower absorption, faster excretion and sweeter taste than its L-counterpart is all I can seem to find on it. I assume it doesnt have any noteworthy differences to its L-isomer counterpart that would warrant its production

I remember reading up on it 5 years ago and came to the conclusion it would not give any inherent benefit over L-theanine
 
All You Have To Do Is Buy A Big Box Of Luzianne Green Tea Bags, Brew It, Drink It, And You Will Barely Be Able To Distinguish The Two (Oolong - Black -Tea Versus Green Tea With Its L-theanine). The Effects Of L-theanine Versus Theophylline Are Subtle But Substantively Exist.

It Is Hypothesized That L-theanine Works By Releasing An Ethylamine CH3CH2-NH2 Residue Inside The Brain.

Ethyl Alcohol (the kind that people drink) CH3CH2OH Is An N --> O Analogue Of Ethylamine CH3CH2NH2. In That Respect, EtNH2 Is Related To The Ammonium Smelling Salts Of Yore.
 
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Rectify said:
All You Have To Do Is Buy A Big Box Of Luzianne Green Tea Bags, Brew It, Drink It, And You Will Barely Be Able To Distinguish The Two (Oolong - Black -Tea Versus Green Tea With Its L-theanine). The Effects Of L-theanine Versus Theophylline Are Subtle But Substantively Exist.

It Is Hypothesized That L-theanine Works By Releasing An Ethylamine CH3CH2-NH2 Residue Inside The Brain.

Ethyl Alcohol (the kind that people drink) CH3CH2OH Is An N --> O Analogue Of Ethylamine CH3CH2NH2. In That Respect, EtNH2 Is Related To The Ammonium Smelling Salts Of Yore.
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Yes L-theanine (N-ethyl-L-glutamine) does break down into ethylamine and glutamic acid in the body but I do not think this is responsible for its pharmacological effects and fail to see how it relates to D-theanine

The literature regarding it seems weird though, it supposedly releases serotonin, dopamine, affects GABA, lowers cortisol and modulates and antagonises glutamate. Maybe Im just a junkie at heart but ive never noticed anything discernible from it other than it making caffeine smoother, feels purely like a cortisol lowering, glutamate modulating supplement for me.
 
Broadly speaking L-theanine stops the stress response, has pro-GABA, anti-glutamate & anti-histamine effects and upegulates the levels of BDNF and glial cell-derived neurotrophic factor (GDNF) which protects & repairs the dopamine system.

Handy tool for anti-anxiety, anti-addiction, tolerance reducing-resetting, and a perfect accompaniment for caffeine/amphetamine/cocaine.

TheLightBringer said:
Maybe Im just a junkie at heart but ive never noticed anything discernible from it other than it making caffeine smoother, feels purely like a cortisol lowering, glutamate modulating supplement for me.
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The magic happens in the 2nd stage of theanines effects, including when the dopamine system upregulates.
 
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Allylbenzene said:
Broadly speaking L-theanine stops the stress response, has pro-GABA, anti-glutamate & anti-histamine effects and upegulates the levels of BDNF and glial cell-derived neurotrophic factor (GDNF) which upregulates the dopaminergic system.

Handy tool for anti-anxiety, anti-addiction, tolerance reducing-resetting, and a perfect accompaniment for caffeine/amphetamine/cocaine.
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I did some anecdotal experiments with oral methamphetamine 20mg + l-theanine. There was a significant decrease in the anxiogenic effects of methamphetamine.

Also l-theanine and l-carnitine combined are a good combination for nutritional support during heavy physical training regiments.
 
Leprechaun said:
I did some anecdotal experiments with oral methamphetamine 20mg + l-theanine. There was a significant decrease in the anxiogenic effects of methamphetamine.
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You might find agmatine has equally interesting synergy. Agmatine is an excellent accompaniment for any stimulant.

Pomegranate juice also, but I'd caution to start with very low doses of the *amphetamine since potentiation can be strong. More info here.

Leprechaun said:
Also l-theanine and l-carnitine combined are a good combination for nutritional support during heavy physical training regiments.
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I wrote this list in another thread but it seems relevant here. It's perfect for enhancing endurance & stamina but works equally well for resolving addictions, repairing the body from drug use, stopping withdrawals and generally enhancing quality of life.

The idea is to enhance mitochondria which produce ATP and anabolic/regenerative hormones like pregnenolone, progesterone, testosterone and DHEA. This is applicable to both men & women.

Here are a few mitochondrial enhancers which work either directly & indirectly:
  • Caffeine (mimics T3)
  • Agmatine
  • Niacinamide
  • Taurine
  • Thiamine
  • Magnesium
  • Coenzyme Q10
  • Aspirin (acetylsalicylic acid)
  • Salicylic acid
  • Creatine
  • Uridine
  • Pyroglutamic acid
  • Succinic acid
  • Pregnenolone (OTC)
  • Testosterone
  • Progesterone (OTC)
  • GABA (GABAergics, reuptake inhibitors)
  • Adenosine (agonists, reuptake inhibitors)
  • Dopamine (dopaminergics, reuptake inhibitors)
  • Amantadine
  • Memantine
  • Anything that blocks cortisol/adrenaline (eg linalool, theanine, CBG, clonidine, everything listed above)
 
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