Stimulants Dexedrine redose

[Wilycoder]

tonight i took 30mgs of dexedrine (dextrostrat 5mg) at once. havent taken it for many years...

will i be ok to take another 10mgs? i am feeling really good and want it to continue....probably gonna be up all night anyways so what the hell, thought i would ask first...the 10mgs would be sniffed instead of eaten (like the first 30mgs was)...

 

[rainbowsix]

Hey Wilycoder. I can't imagine that another 10 would push anything too far, but we're all different and have different tolerances. Maybe play it a little safe by sniffing only 5mg and see how it goes before doing the other 5. Maybe ou won't need it and can save it for another day.

 

[pizzystrizzy]

Snorting pills isn't really good for you due to the fillers in the pills. Better would be to take it orally with an antacid or baking soda, which would increase its bioavailability and, by making your urine more alkaline, make the entire thing last longer because it will take longer to excrete. How long ago did you take the 30mg? Are you certain you even need to redose? Are you certain you want to stay up all night? amphetamine at these doses is relatively safe, but when you combine them with staying up all night you are putting a lot of stress on your brain (and the rest of your body). Did you try taking some caffeine first? That often amplifies the dose and helps bring it back a bit when it starts to wane.

I'm not saying not to do it, but if you are feeling really good already, really consider if you need to take more, as I suspect you'll pay for it in how you feel tomorrow.

 

[Wilycoder]

took first dose around 9:30pm, it took around 90 mins to start working. i was assuming that sniffing would start sooner and i dont want the redose to take 90mins to start...

also i am trying to minimize the crash, been drinking the recommended amount of water, just ate some food (which would delay redose onset even further)...

 

[pizzystrizzy]

Well, I dunno, 40 mg isn't an outrageous total amount-- some children are prescribed that amount on a daily basis. I still don't think it's a great idea but if you are going to do it, make sure you are going to resist the urge to take more when that dose wanes. And try to get some sleep, even if just a little. In any event, I'm quite certain that that same 10 mg will go a lot farther if you take it tomorrow than it will if you take it now, if only because of tachyphylaxis. The elimination half-life of d-amph is like 10-12 hours, which means even without the 10mg you'll still have 15mg in you at 8 in the morning. You certainly still have the majority of your initial dose unmetabolized now, just four hours later. When it is wearing off it is less because the drug level is going down and more because of acute short-term tolerance. If you snort the 10mg you'll probably feel it, but you won't get as much out of it as you otherwise could.

The above idea of snorting 5mg first and waiting 20 minutes or more is also a good one in terms of playing it safe. And check your resting heart rate first to make sure it isn't already higher than you are okay with.

 

[Znegative]

I don't think an extra 10mg will have any effect other than prolonging the comedown perhaps. Usually I find that with amps, once you're in a nice place, taking more wont make it nicer..it'll usually do the opposite or nothing at all. The best time to redose is after you've already come down for a few hours, but it still won't bring you back up in the same way. It's hard but you'll find that you get the most out of amphetamines if you use then as infrequently as possible and keep the dosages on the low side. I break this rule myself and usually dose 2xday, but always hours apart, like in the morning and then the evening. I also never use more than 60mg/day (and that's with adderall which is slightly weaker than dexadrine).

 

[AlphaMethylPhenyl]

10mg more would be alright, just beware that the crash gets a lot worse the more you take, and the more you re-dose.

 

[Ksa]

tonight i took 30mgs of dexedrine (dextrostrat 5mg) at once. havent taken it for many years...

will i be ok to take another 10mgs? i am feeling really good and want it to continue....probably gonna be up all night anyways so what the hell, thought i would ask first...the 10mgs would be sniffed instead of eaten (like the first 30mgs was)...

I should make a software for this too lol. Yes you're ok to take an additional 10mg. Try to keep the doses even though, if you take 30mg IR the first time it's too much, I would do 20mg first and 20mg later.

40mg/day: Recommended maximum dose for therapeutical purposes
60mg/day: Toxicity 5% (ear ringing)
100mg/day: Toxicity 15%
150mg/day Toxicity 35% (bad comedown)
250mg/day Toxicity 55% (severe comedown)
350mg/day Toxicity 75% Death statistically unlikely but can occur.
450mg/day: Toxicity 90% Death could occur, dangerous
600mg/day: Toxicity 99% LD50, 50% chance of death

For the amphetamine naive person.

 

[AlphaMethylPhenyl]

^Where did you get that information?

 

[Ksa]

^Where did you get that information?

Someone has to know...I know because it's my buisness to know. It's what I do. From books...Medicinal Chemistry, Patrick and so on.

 

[AlphaMethylPhenyl]

Ok but you have a definite source? Can you give me the book? I'm not contesting your data, it seems about right, I was just wondering if you could tell me where you got it from.

I thought it depended on ones weight.

 

[Ksa]

Ok but you have a definite source? Can you give me the book? I'm not contesting your data, it seems about right, I was just wondering if you could tell me where you got it from.

I thought it depended on ones weight.

There is no data. Amphetamines have a low weight dependence compared to opioids so I couldn't think of a /weight data that would be reliable. Like, 15mg dexamphetamine could stimulate a 250lb athlete as much as a 120lb skinny dude, there is very few dependence. Data mostly comes from suicide and suicide attempt cases that I've read over years, I sort of have a mental picture of what each dose does.

 

[Wilycoder]

well taking the extra 10mgs ended up being useless. It didnt bring the peak back. sniffing it was dumb too.

for the amount of euphoria i got last night, i am feeling surprisingly ok today.

 

[pizzystrizzy]

What are the 'toxicity' percentages referring to? Percentage of what?

 

[Ksa]

A Propos...I keep seeing on the news "she died after a suicide attempt", like, if she died, it means it wasn't an attempt! It always cranks me up to hear it lol.

You know that girl who got tossed and raped? She decided to slit and now I hear that on the news lol! Died after suicide attempt, what the dick!?

 

[AlphaMethylPhenyl]

well taking the extra 10mgs ended up being useless. It didnt bring the peak back. sniffing it was dumb too.

for the amount of euphoria i got last night, i am feeling surprisingly ok today.

Amphetamine is relatively forgiving in regards to lowish doses after one use.

 

[Ksa]

What are the 'toxicity' percentages referring to? Percentage of what?

0% means no permanent damage is done to your amphetamine naive brain so you can take that forever without suffering any brain damage, 100% means that this is the most permanent damage that the drug can do to your amphetamine naive brain. Because people ask about the permanent damage and how bad a dose can affect them. Like, 55% doesn't mean your brain is 55% fucked up. Lol

 

[Ksa]

Amphetamine is relatively forgiving in regards to lowish doses after one use.

Yes and changing the mode of administration is also a bad mistake. If you start with oral, you continue with oral until you've crashed 100%, if you start with snorting you snort until you crash 100%.

The only time a 10mg could be influencial after a 30mg IR dose is if you take it 3-4 hours after the 30mg IR dose and that you use thums, OR a strong PI like ranitidine 150 or Nexium 1-2 hours before the second dose.