Dexamphetamine vs. selegiline & cognative funcation

[AlexxRed]

well that might have helped me answer my own question...

As someone that has used selegiline alot have you got any other comments?

 

[Morb]

cognitive is spelled cognitive ;-)

That is one of the most common, though I find definately a bigger annoyance and don't forget there's a rat in separate (as opposed to desperate). Ah well, I find succor in the relativity of wrong but spelling is a lost art.

My 2 cents:

I took Emsam (transdermal selegiline), which I believe is not selective for MAO-B at any of the patch dosages, unlike selegiline in pill form. I didn't notice any cognitive improvement. Normally I take dextroamphetamine and it greatly improves concentration, focus, motivation (to some degree), and also helps me organize my thoughts better than in a normal, drug-free state.

I think you have that backwards. Emsam patch I believe comes in 20,30,40mg whereas most deprenyl pills or drops I've seen/owned come in 5mg or 1mg respectively. Selectivity is maintained up to 10mg, do the math. If you're living on dexedrine then you probably wouldn't notice. I would be careful combining those two at high dosages. I was showing my psy these depression studies a year before the fda released the patch (either way you look at it fda=pharmacos) and she still wouldn't give it to me. Amphetamines and tricyclics oh yes that dangerous combo but no dep baby because well she's a doctor.

 

[nanobrain]

the notion of transdermal soaking is a bit too reminiscent of the former USSR GULAG high - ya shave yaself a bald patch on yo pate, then apply a solvent mix (usually things like surfactants and detergents and fuel oils - the only things avail) to a sock, put same on bald patch on head under a hat. voila! transdermacranial delights....

 

[Blador]

How can only 6mg over 24h be nonselective? What is the oral bioavailability of selegiline?

 

[nanobrain]

^fairly low and i can vouch for nonselective inhibition even at <10mg/d via oral. careful.

 

[Morb]

I don't drink alcohol & have never taken more than recommended of paracetamol so pemoline isn't a worry in the liver dept., but yes if you have a dodgy liver then pemoline might not be the best choice

What do you think about milk thistle for liver protection with something like amps?

 

[streetsurfer]

Selegiline's absorbtion is not only low, it is unpredictable. I put some olive oil in a blank cap and dropped half a selegiline, did up about 50 of em. I found that it made them very consistant in their effect. Sublingual is also good which is how I take it now (yukky)

 

[Revrent_mike]

I notice improved thinking/memory within 20 minutes of my first dose. And then it got better from there. I had been a basket case. Couldn't think at all -- totaly deprssed and confused all the time. I'm a computer programmer and I could no longer work. Within 2 days I was back to almost normal. Over the next two weeks I grew. I never got the knack of speed reading. And now I can. It just started happening.

Of course, this is if your symptoms are in fact due to a L-dopa deficiency. Many folks take it and don't notice a thing. In my case it was a life saver.

 

[Blador]

I notice improved thinking/memory within 20 minutes of my first dose. And then it got better from there. I had been a basket case. Couldn't think at all -- totaly deprssed and confused all the time. I'm a computer programmer and I could no longer work. Within 2 days I was back to almost normal. Over the next two weeks I grew. I never got the knack of speed reading. And now I can. It just started happening.

Of course, this is if your symptoms are in fact due to a L-dopa deficiency. Many folks take it and don't notice a thing. In my case it was a life saver.

So.. you've been taking levodopa? Or did you mean "dopamine deficiency"? I'm curious either way, what's been your drug diet? Any other effects noted?

 

[Morb]

So.. you've been taking levodopa? Or did you mean "dopamine deficiency"? I'm curious either way, what's been your drug diet? Any other effects noted?

If you're thinking about taking selegeline with l-dopa, don't. That is where all of the negative research lies as a pubmed search will quickly reveal. Of course that is in parkinson's patients, but it doesn't sound like a promising combo.