Dexamphetamine is a straight street drug

[ayjay]

hmmm dunno - the dex isn't affecting receptors - just the amount of DA in synapse

 

[Crankinit]

I've always thought it might have something to do with low levels of dopamine, or some fault in the dopaminergic system. If dopamine is released as a reward for completing a task successfully, and you're not getting your proper fix, then you'll end up jumping from one task to the next with no real focus or ability to concentrate since your brain has never associated the reward with the task, stimulants correct this by increasing dopamine levels to their norm.

But that's just my oversimplified, uneducated guess.

 

[footscrazy]

I don't know enough about the theory or neurology to really comment, but it seems that if the solution was lowering dopamine concentrations antagonists would have the same sort of result, but I dunno.

I've always thought it might have something to do with low levels of dopamine, or some fault in the dopaminergic system. If dopamine is released as a reward for completing a task successfully, and you're not getting your proper fix, then you'll end up jumping from one task to the next with no real focus or ability to concentrate since your brain has never associated the reward with the task, stimulants correct this by increasing dopamine levels to their norm.

But that's just my oversimplified, uneducated guess.

Yeah I agree with this, it seems to follow on to why activities like cleaning, gambling, sex are so much better on meth/amphetamines, because you're getting a much higher reward than usual for doing them. (And why I have the attention span of a goldfish after going hard...)

 

[Ignatius J.]

oh yeah sorry. i probably should have specifically referred to the role of dopamine in ADD. Quite a few studies have shown that people correctly diagnosed with ADD/ADHD have much lower dopamine concentrations in their frontal lobes than normal individuals. Some how they can see this when they stick you in an MRI tube...im not sure of the technical details but I have read several studies proving this theory which i'll go look for again.

Psychostimulants are most effective because they have a specific affinity for the frontal regions of the brain. For example, the dopamine efflux caused by Amphetamine is most highly concentrated in this region. This is why a normal person, when high on amphetamine will sit there and pund away on the same repetive task over and over again...way to much reward going on in there for completing simple little things. Its also why you cant get "high" on anti parkinsons medication (or use it in the treatment of ADHD) which increases dopamine throughout the whole of the brain..its not a pleasant experience at all.

So yeah, to me the most plausible theory to me is that..ADD has definitely got to do with lack of dopamine...but its got to be in a specific area of the brain. If it was just a generalised lack of dopamine there would be co-morbid symptoms of parkinsons. Interestingly enough, as a sufferer of ADD, i also have a very well established family history of pakinsons disease, on my maternal side my grandmother and grandfather have/had it as did my grandmothers mother and her mother before that. Interesting.

 

[MrIbis]

All i know about D-Amp is how much it helps a few of my friends.

One of them has Aspergers Sydrome, coupled with ADHD and a few other things, and he can't operate properly without it. Even getting out of bed is a difficult task.

 

[Galant]

me and most of the people i go out with eat or snort dexies most weekends, doses are mainly between 2 and 10 pills although i know someone that ate 100 in 3 days

 

[MrIbis]

I had a mate eat his whole bottle once.

I'll tell you this, If you have ever questioned the purity of your drugs based on subjective effects - 500mg of pure d-amp will do the trick to making you feel like you're having a heart attack for 3 days.

If 500mg of the meth you're getting isn't doing the same - I think we have a problem

 

[puckboy]

^
Ugh, that's a stupidly large amount of d-amp to eat at once regardless of tolerance. You're right about d-amp causing strange and possibly negative effects on the heart and the PNS and CNS in large doses. Meth is far more recreational in the sense that the high:side effects ratio is far better than d-amp, meaning a longer, better high. Making it far more desirable and easier/more worthwhile to binge on.

 

[Crankinit]

^
Ugh, that's a stupidly large amount of d-amp to eat at once regardless of tolerance. You're right about d-amp causing strange and possibly negative effects on the heart and the PNS and CNS in large doses. Meth is far more recreational in the sense that the high:side effects ratio is far better than d-amp, meaning a longer, better high. Making it far more desirable and easier/more worthwhile to binge on.

This is definitely true, d-amp feels much harsher on the body than meth ever did, it's pretty hard to maintain a consistant high after 12 hours or so, the PNS/cardiovascular side effects overtake the high fairly rapidly at that stage. It's not something you want to binge on for days at a time without sleep (not that it's necessarily recommended to do so with meth either, but if you're going to binge for days, meth would be preferable).

 

[my innerself]

I used to get 5mg dexies from a mate and would drop 10 to 15 at one time. I fucken love the shit. A nice clean strong speed feeling. Used to blitz through the work to.

 

[BloodTranceFusion]

...would drop 10 to 15 at one time. I fucken love the shit. A nice clean strong speed feeling. Used to blitz through the work to.

You'd drop that many to be functional or is this for partying?

My work dose is 3 first then 1,5 every subsequent 2,5 hours. I'm 195 tall and weigh maybe 70 (ever-decreasing thanks to dextro).

Yet a mate does 4 then 2 et cetera. He'd be 180 and 80.

What does everyone else take to work and to play?

What's the height and weight of Mr 100? Haha.

 

[belarki]

^ if we're going to be comparing dosages it might help to specifiy your weight, height and tolerance (perhaps time using and typical dose)? The last thing any of us want is someone stumbling across the thread and taking a guess at a suitable dose based on what others have posted & not the advice of a medical practitioner.... and hence placing themselves in danger.

Be safe guys/gals

 

[footscrazy]

I don't really see any HR value in posting amounts and I think it'll just turn into dicksizing. Like Belarki has already said, it's dependent on so many different factors that no-one can reliably compare themselves to someone else. Good HR practice means taking a small dose first, which you can always build upon later if need be.

 

[specneck]

Well that depends on how you feel about ADD as a medical condition.

I'm personally of the opinion that ADD does exist (although is probably over diagnosed), and for treating ADD I'd imagine dexamphetamine is a far superior to methylphenidate or any of the other alternatives. I've known people who've had their life improved substantially with ADD treatment.

Yes, it's abuseable, but that doesn't negate the medical potential. Should we deprive people of medication that improves their quality of life because other people abuse the same medication? That's absurd.

Yeah I agree about the fact that people should not have medication taken away that does improve their lives.

However I was on 50mg dexamphetamine + 20mg ritalin - (methylphenidate) when I was in school. I found that I HATED the dexies.. just ended up selling them cos I didnt want them and the demand was high.
The ritalin however made me feel more calm but still alert but wasnt as intense as the dexies. I preferred them much more.

In saying all this, I dont think school was for me. Although highly competent, I just wasnt into it.

Hands on stuff for me is the way to go and thats how I learn best. Rote-learning just seems so hideously boring and I cannot just sit there and read text for hours on end.

But thats what ADD is all about.

I would have preferred never to take any meds at all because I became very socially withdrawn. Was very popular at first and then after starting meds, I just didnt wanna hang out with anyone any more.

But there are few alternatives in this rigid education system.. shouldve quit school and done an apprenticeship but then, hindsight is always clear..

 

[dj_esky]

I have ADHD, I'd probably be jumping off the walls if it wasn't for dexamphetamine. if i skip a dose accidently i usually do end up bouncing like crazy.

and yes sadly its a street drug too. i have had a bottle stolen from my bag when i was studying music in TAFE, I had to do the whole course again because of that.

 

[puckboy]

I've always wondered, is Dexamphetamine Sulphate (dexies) the same/similar chemical that is the majority of street speed in Europe? Amph Sulphate? Or am I completely off?

 

[Crankinit]

I've always wondered, is Dexamphetamine Sulphate (dexies) the same/similar chemical that is the majority of street speed in Europe? Amph Sulphate? Or am I completely off?

I'm fairly sure most street speed in europe is racemic, so it's 50% dexamphetamine (sulphate I think? not sure there), and 50% levoamphetamine.

Much like meth, the l-isomer kind of sucks and doesn't add much to the recreational effect. I don't understand how people would binge on racemic amphetamine. Even pure d-amp feels like hell on the body after a certain stage, racemic would be even worse.

 

[hyroller]

did someone say stimulants?

my initial thought is always, 'where's mine'?

that said, I munched through my last ritalin last weekend. quite impressed as I've kept this stash for well over 8 months. but it was time. if I could procure pharm grade stims all the time, then I would. the nice, neat, exact dosages make the whole process much less 'touch and go' on my end, and rarely lead to disappointment given that they are known quantities...

not to mention, they come at a fraction of the cost.

 

[HiLiKuS]

I used to take dexies when i was in high school at music festivals etc cause my older brother wouldn't let me take speed. worked a treat in keeping a small kid going crazy in BDO pits.

I'm much older now and i was recently at a mates younger brothers 21st party where many were charging on dexies. I asked one that I knew as to why they were all popping dex and I was impressed to hear that it is because pills and rc's are too fucked these days. Just like forest said, you never know what your going to get.

I thought well fair enough, least its pure pharm grade and its giving more of a desired effect than all the other crap.

still there is no substitute for MDMA.

Has anyone else thought about moving to America, joining the army, freaking the fuck out pretty soon after joining, immediately developing post traumatic stress syndrome and get treated with pure pharm grade MDMA for a very long and slow rehab process?

 

[Crankinit]

I used to take dexies when i was in high school at music festivals etc cause my older brother wouldn't let me take speed. worked a treat in keeping a small kid going crazy in BDO pits.

I'm much older now and i was recently at a mates younger brothers 21st party where many were charging on dexies. I asked one that I knew as to why they were all popping dex and I was impressed to hear that it is because pills and rc's are too fucked these days. Just like forest said, you never know what your going to get.

I thought well fair enough, least its pure pharm grade and its giving more of a desired effect than all the other crap.

still there is no substitute for MDMA.

Has anyone else thought about moving to America, joining the army, freaking the fuck out pretty soon after joining, immediately developing post traumatic stress syndrome and get treated with pure pharm grade MDMA for a very long and slow rehab process?

I don't think it works like that. From what I gathered it's used during therapy sessions to help break down emotional barriers and allow the patient to be honest and open with themselves and the therapist.

It's not like they give you 100mg of MDMA and say 'here, have fun!'