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  • Trip Reports Moderator: Cheshire_Kat

(Desoxypipradrol/10 mgs) First experience: Which way is Poland?!

Desoxypipradrol is the name Ciga Geigy used when trialling it for clinical use, but a lot of papers on DAT inhibitors & such use the name deoxypipradrol.

The less important noradrenergic reuptake inhibition is probably responsible for it's mild appetite supression at higher doses
 
gabbachris

turkeyphant said:
So it's a bit morish, then?
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That Morish brainwave only stems from a habit our brains have grown accustomed to by snorting other shorter acting powders. It advises you to have another line at the appointed time regardless of how high you are or how long you are likely to be effected for. Desoxy Pipradrol has much potential but will never go mainstream because wisdom is required to use this drug safely.
 
I'd just like to throw in that 13mg IM was pleasant, but I had no trouble sleeping 8-12 hours later.

I should mention that I sleep best on 20mg of adderall, so I may be even more of a freak than Xorkoth.
 
Table of reuptake inhibition values of various drugs (including desoxypipradrol) for dopamine & noradreenaline). From, RM Ferris, FLM Tang; J Pharmacol & Exp Therap (1979), 210, p422.

Not for the R isomer of desoxypipradrol (deoxypipradrol in this paper) the action at synaptosomes is slightly greater for dopamine at 3.6 x 10^-8 M (36nM) than noradreenaline at 5.3 x 10^-8M (53nM). This is the isomer which is predominantly active

Thanks to Aiden of TCC for getting me a copy of this paper
 

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Not really as the tolerance rises pretty quickly (probably attributable to the long half life to some degree), so that the dose has to escalate pretty rapidly (for a stimulant) to keep fatigue at bay. One way this is expressed is in a shorter length of action (even while some remains in the bloodstream). That's from personal experience investigating it.

Still, even 3 days without sleep can cause some people to lose the plot quite badly
 
MDPVagrant said:
Damn strange... about 15 minutes ago I was in the process of falling asleep (actually just about there) when I was hit out of the blue with sudden extreme, unbearably intense agitation that immediately woke me up. My ears started ringing loudly and I was literally crawling out of my damn skin.

Got out of bed and dosed 150mg of pregabalin, which made only a very small dent (believe me, I'd have taken anything I could get). This must be related in some way to desoxypipradrol... it's been 18 hours or so since the last dose, but it must still be plenty active. If the feeling gets any worse (despite liberal use of calmative agents) I will have no choice but to visit the nearest hospital ER and request something really strong like Seroquel or Haldol. There's no doubt in my mind this was based on physical factors, probably some derangement or imbalance in brain chemistry. I had taken some 5-HTP earlier, but this did not behave like serotonin syndrome (not to say it couldn't have played a part anyway). The accompanying tinnitus is troubling, but there haven't been any other physical symptoms suggestive of e.g. TIA or stroke.

I knew I'd run into SOME kind of issue with a stimulant that just keeps going and going and going for an unpredictable, absurd length of time. Really, I'm puzzled as to why I wanted to mess around with something like this. I don't care how freakin' cautious a person is... they can measure out 5mg on their $800 scale, dose once and they're still playing with fire f*cking with their brain chemistry around the clock for days on end. At best it makes no sense when there are other/similar stims out there that actually wear off the same century they were ingested.

P.S. it's been an hour & a half... feeling a lot better, in case anyone was concerned. Stims are becoming such a f*cking drag lately -- crossword puzzles & basket weaving are starting to look attractive in comparison.
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I should probably have reported this in more detail but when I was trying to fall asleep both on the second and third night up I experienced something similar to you. The first time I had been laying there for quite some time and when I finaly felt like I was drifting off I heard a very loud alarm/siren type thing in my head and was totaly paralysed for several seconds till it wore off. It was extremely frightening and I wasn't sure for a while if the alarm thing was real or not.

The next night was the same but less intsne and scary. I was paralysed again for a few seconds and felt extremely scared. Both times I was sort of drifting off but this got me all worked up and stopped me from sleeping again.

Best thing I can relate it to is sleep paralysis after mdma binges, but this was more alarming.
 
Would this be a good first stimulant?

My main concerns with stimulants are addiction potential and negative side effects. For these reasons I have pretty well avoided all stimulants (other than caffeine, kola nut and some coca leaves in Peru). To me coke seems pointless and empty and meth WAY too addicting. I think I may be a bit sensitive to stimulants as 1.8mg of DOC had me feeling pretty overstimulated (thank you valium!).

What interests me about this compound as it seems much more functional and has less potential for abuse. I really like the idea of being able to be motivated and stay awake for long periods of time with a decent mood and be productive. Something that is 'good', but not 'too good' if you know what I mean. The rapid tolerance seems to be a built in safety mechanism to help avoid dependence from developing. The fact that its not a street drug (meaning it should be relatively pure), has been pretty extensively tested and has a good therapeutic index it also a major factor in its favor.

I don't want to invade Poland, just a little taste of hypomania to get my ass in gear. =D
 
Plenty of people seem to get a great deal of positive things from it, so it may be that it's because of combining other drugs that have produced this state in you. I still find it enjoyable & useful, but that's with sticking to say a 4mg dosage for the day
 
5mg = simply superb ... requests menu ... ah sir would like a main course of sleeplessness followed by 5mg of desoxy ... indeed

Very speshal little stim this one :)
 
Yeah, I couldn't imagine going higher than 5mg unless there are reinforcing properties that make me redose. I'm sure I'd learn my lesson quick.

In terms of sleeplessness, I'm sure benzos would do the trick just fine.


Another quick question. I have a friend that is a daily "ice" (meth) user, could this be used as a substitute and a way to taper off of the ice? My friend uses the ice nasally rather than smoked, so I believe its not quite as addicting that way. Of course this is assuming this would be a beneficial thing to do.
 
I experimented yesterday with 10mg, due to my reactions to lower doses last time being a bit too weak.

I had a good bit of euphoria, certainly not on the level of amphetamines, but longer and more consistent than MDPV and better also unless I compare it to a very large dose of MDPV with redosing. I took it at 7am yesterday, and went to bed at 2am, and it only took about 10 minutes to fall asleep, which is a lot for me (I tend to turn my mind off so easily that I fall asleep as soon as I hit the pillow). Not a very refreshing sleep, but I got 5.5 hours of it, so i feel pretty good today, just a bit tired.

I find the euphoria with this one pretty decent and it has few side effects unless you dose too high. It does me tap my foot pretty much non-stop all day, although I do that to a lesser extent anyway because my metabolism is very high and I have loads of energy almost all the time.

I don't find this one particularly addictive. It looks like we have some different types of responses to this material. Some love it, some like it (such as me), and some dislike/hate it.

To further illustrate difference in substance effects, I personally also use kratom a lot, and I find it to mix very well with stimulants, or the majority of them (including this one). I also find that invariably, with any drug I've tried that has enagtive aftereffects/hangover, if I take kratom, especially shortly before bed, not only will I feel much better immediately, but I will never get nearly as bad a hangover. When I used to drink, I would get very, very drunk, and if I didn't take kratom after I was done drinking, I would feel wretched the next morning, but if I did, it would sober my mind up but make my body buzz awesome, and the next morning I would feel pretty good, not perfect, but much better.

YMMV
 
all y'all 'membah way back when i done toldja that dat MD-PV will skewer your response to other stims forevah aftah, amen?

and interesting to note that MDPV is becoming the standard of reference most often quoted.

and dontcha be messin w/ Mr Vagrant, he's been caineing his rats in the name of science, dammit; fearless rodents who i bet at this very moment are busily transforming the very fourier.
 
Nanobrain, I still don't buy that spoiling the user for all other dopaminergic drugs theory. MDPV is just the best one so far, with methylone as second. I agree that MDPVagrant's rats are indeed overworked, but probably not spoiled in the dopamine sense.
I have not had the chance to try any desoxy yet, but it is unlikely that MDPV ruined the fun. Probably more likely, like 2DPHMP and 1,3dimethylamine, it is good for staying awake, but no fun...
I'll report back when I have firsthand data from my own lab-weasels..
 
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