I got some Desoxy today, and couldn't wait to dive in. I dissolved 40mg in 10ml of alcohol and took 3mg about 14 hours ago.
Around 40 minutes in I had a bit of a headache but it was tolerable. There wasn't any euphoria or urge to invade other sovereign nations, but I did notice a definite energy lift and increase in focus as well as a bit of a mood lift.
I went on a 9 hour cleaning/packing binge which was quite productive. I'm preparing to move soon, and I just organized the last 5 years of my life and went through stacks of unopened mail etc. I even found an uncahsed paycheck for $500 from Feb 2006! Which shows how often I clean this thoroughly.

Around 4 hours in I noticed a slight energy dip but it was likely because I hadn't really taken a break. After a small break I was back to full stream.
Ten hours after taking the desoxy (around 2am), I took a break and started to get fairly tired. At 2:30am I thought I could fall asleep because I was tired, but it obviously wasn't going to happen. I layed in bed for about an hour and a half and I was pretty fatigued and felt a bit sketchy with a headache. After I decided to get up the sketchy feeling went away and after eating I felt pretty normal.
At this point my initial impressions are positive. The first 10 hours or so were pretty much exactly what I was hoping for, energy, motivation and focus but without much to make me want to use it recreationally. In the future I'll probably take right after I wake up rather than later in the afternoon, I was just anxious to try it. In a few days I might try 5mg and see if I can find my sweet spot.