Benzos Deschloro-etizolam or Etizolam-2 - a new thienodiazepine research chemical

[dorian.927]

Yesterday night I tried deschloroetizolam once more at the high recreational dosage of 25 mg. On the basis of my nearly absence of tolerance, I found this dosage slightly more potent than 40 mg diazepam so I reconsider my assessment above : one pill of 5 mg deschloroetizolam = 8.5 mg diazepam. But during the night it was a disaster : there was a very noticeable hypnotic effect, yes, but the night was then "poisoned" by nightmares, vertigos, slight and undepictable nausea. The only good thing was a welcome anxiolytic effect that is prolonging today.

 

[Esperighanto]

Yesterday night I tried deschloroetizolam once more at the high recreational dosage of 25 mg. On the basis of my nearly absence of tolerance, I found this dosage slightly more potent than 40 mg diazepam so I reconsider my assessment above : one pill of 5 mg deschloroetizolam = 8.5 mg diazepam. But during the night it was a disaster : there was a very noticeable hypnotic effect, yes, but the night was then "poisoned" by nightmares, vertigos, slight and undepictable nausea. The only good thing was a welcome anxiolytic effect that is prolonging today.

While I've personally never experienced the nightmare inducing effects that you've mentioned here, I worked with deschloroetizolam in crystal form so I was using it as a liquid I'd dry into blotter, candy lego blocks, or drop straight in my mouth. Vaporizing some was alright but pretty dissatisfying compared to vaporized etizolam. Deschloroetizolam really shined via oral/sublingual RoAs though, where it would last much longer than etizolam with more of that feeling that diazepam or triazolam can elicit, the feeling of a permanent ray of golden sunshine beaming down on me wherever I am. Buying gas station drugs, cleaning my living space, vacuuming my car, all of these things feel like the song I'll Be There For You by The Rembrandts (Friends' theme song) has instilled its very energy into me.

Interestingly enough, the combination of deschloroetizolam or bromonordiazepam alongside MD(M)A elicits a much more energetic variant of the feeling that's also days long. Deschloroetizolam always lasted into the next day, whereas bromonordiazepam always lasted into the next week. I found 5mg of deschloroetizolam about as potent as your comparison to 8.5mg of diazepam, maybe I'd say more like 12mg or so but I'm specifically heavily affected by diazepam and derivatives for a reason I can only suspect to be metabolic quirks. I suspect that the lack of an R2 substitution may be to blame for this common effect, as deschloroetizolam, diazepam, bromonordiazepam, and actually also triazolam (which feels like this too, imo) all have an unsubstituted position at R2 (the bottom phenyl ring of the traditional 1,4-benzodiazepine scaffold).

 

[pcplease]

i have had weird and/or bad dreams, probably at least a night terror or two after deschloroetizolam but for the most part it feels to me like it impairs overall sleep far less than most or all other benzos. and i have used nearly all of the rcs extensively. and closer to 2mg deschloroetiz = 10mg diazepam for me

 

[dorian.927]

Thank you for your experience reports.
I wonder if the absence of halogen atoms in the molecule of deschloroetizolam could explain the lack of reliability in its effects, a bit like nitrazepam in some people.

 

[pcplease]

i could be wrong as we're talking over a decade ago now but i had thought something unique about etizolam itself was that it sort of floated around changing which bzd binding site (/ratios) it affects. which i would think tends towards varying effects for diff individuals. but i think theres a lot of variance w all of them tbh. few like alprazolam, seemingly etiz pretty consistently dopaminergic for most everyone

 

[funkalistic1]

What the heck is this ?

2-ethyl-9-methyl-4-phenyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine
Chemical Formula: C₁₇H₁₆N₄S
Molecular Weight: 308.40
m/z: 308.11 (100.0%), 309.11 (20.7%), 310.11 (5.0%), 310.12 (1.6%)
Elemental Analysis: C, 66.21; H, 5.23; N, 18.17; S, 10.40
CAS No. 40054-73-7
CBNumber: CB92681341

aka: Etizolam-2, deschloro-etizolam, 4-ethyl-13-methyl-7-phenyl-3-thia-1,8,11,12-tetraazatricyclo[8.3.0.0^2,6]trideca-2(6),4,7,10,12-pentaene

It looks like Etizolam without the Chlorine on the Benzene ring.

Any info on it ?
Any experience ?

Wikipedia article
older thread

Do yourself a favour and be very careful with the triazo benzodiazepines as they are much more potent than regular benzodiazepines and you will become dependent much quicker and let me tell you benzodiazepine withdrawal is more dangerous than almost any other type Except for delirium, Tremors or alcohol withdrawal you can actually die from it unlike opioids. benzos you can have seizures and die from the withdrawals so I would strongly suggest caution with thenio benzodiazepines, or triazalobenzodiazepines. They are up too 100x more potent and have NASTY withdrawal effects. Be cautious. Think on the potency level of Carfentanyl compared to OxyCodone or Demerol.

 

[4DQSAR]

Yeah - we went down the slightly different path of substituting etizolam for what we named 'metizolam' i.e. it lacked the 2-methyl. But in all other respects, both deschloroetizolam and metizolam appeared to be very similar (in the study we carried out).

Why metizolam? Because the Indian producer could simply swap the acetylhydrazine for formylhydrazine (in eqimolar amounts) thus until the last 2 steps, synthesis of metizolam and etizolam were identical. With deschloroetizolam one has to start with a different precursor and optimize more steps. So 'for ease' is, I think, the reason we went with it.

To be clear, this was when RCs were legal in the UK.

 

[pcplease]

i have never been able to source metiz in the us, but some deschloroetiz is still available. costly though as it hasnt been produced in a long time it seems. i liked fluclotizolam more than flubrotizolam, by far, but bulk fluclo disappeared before flubrotizolam. i think ive read positive clotizolam reports, and wanted to try it hoping for someting around etiz , fluclo was much stronger. deschloro is weaker by weight but a longer acting, less BZD-predictably, more drunkenly intoxicating effect and much longer acting. ived like them all for respective purposes.

 

[4DQSAR]

My guess is that since ALL benzos are now equally illegal, makers are simply looking for the biggest product. Sadly that's likely to be something like flunitrazolam - well, a nitrobenzodiazepine almost certainly. I don't claim to know why but I read about the intentional overdose cases in Sweden and noted that 100% of the deaths were from nitrazepam or flunitrazepam. The latter is much more potent so logic might suggest it to be safer, but for whatever reason, that doesn't appear to be the case.

I would be VERY cautious with any and all RCs on the market these days. Lack of proper competition has resulted in Grisham's law taking over. A maker HAS to make the most potent example because their competitor WILL and can then sell at a lower price...

All very worrying. By all means have fun - but nothing it worth the rest of your lives.

 

[pcplease]

i think a big part is lack of interest from people like you who are smart enough to figure out more novel synthesis. china doesnt produce them til a known easy synth is available- see their inability to produce pyrazolam despite heavy demand. instead we got 7-oh-phenazepam. flubromazepam from phenazepam, flubromazolam from that, and then we got bromazolam and now flubromazolam. phenazolam popped up on that swedish forum nearly a decade ago, IIRC.

phenazolam is incredibly potent, very long acting slow onset sold as alprazolam. fortunately not the rebound anxiety/withdrawal of clonazolam/clonitrazolam but 0.25mg is at least 10mg+ diazepam. bromazolam was pretty close and the new ethylbromazolam by reports it to be even more similar. i love it as a chem but it is absolutely not for novices. nitrazolam wasnt very popular. flubromazepam showed cardiotoxiciticy so that fact alone worries me they carry their own risks.

theres a pubmed case report listing cause of death by clonazolam alone from i believe someone really young like 14