Benzos Deschloro-etizolam or Etizolam-2 - a new thienodiazepine research chemical

[dorian.927]

Yesterday night I tried deschloroetizolam once more at the high recreational dosage of 25 mg. On the basis of my nearly absence of tolerance, I found this dosage slightly more potent than 40 mg diazepam so I reconsider my assessment above : one pill of 5 mg deschloroetizolam = 8.5 mg diazepam. But during the night it was a disaster : there was a very noticeable hypnotic effect, yes, but the night was then "poisoned" by nightmares, vertigos, slight and undepictable nausea. The only good thing was a welcome anxiolytic effect that is prolonging today.

 

[Esperighanto]

Yesterday night I tried deschloroetizolam once more at the high recreational dosage of 25 mg. On the basis of my nearly absence of tolerance, I found this dosage slightly more potent than 40 mg diazepam so I reconsider my assessment above : one pill of 5 mg deschloroetizolam = 8.5 mg diazepam. But during the night it was a disaster : there was a very noticeable hypnotic effect, yes, but the night was then "poisoned" by nightmares, vertigos, slight and undepictable nausea. The only good thing was a welcome anxiolytic effect that is prolonging today.

While I've personally never experienced the nightmare inducing effects that you've mentioned here, I worked with deschloroetizolam in crystal form so I was using it as a liquid I'd dry into blotter, candy lego blocks, or drop straight in my mouth. Vaporizing some was alright but pretty dissatisfying compared to vaporized etizolam. Deschloroetizolam really shined via oral/sublingual RoAs though, where it would last much longer than etizolam with more of that feeling that diazepam or triazolam can elicit, the feeling of a permanent ray of golden sunshine beaming down on me wherever I am. Buying gas station drugs, cleaning my living space, vacuuming my car, all of these things feel like the song I'll Be There For You by The Rembrandts (Friends' theme song) has instilled its very energy into me.

Interestingly enough, the combination of deschloroetizolam or bromonordiazepam alongside MD(M)A elicits a much more energetic variant of the feeling that's also days long. Deschloroetizolam always lasted into the next day, whereas bromonordiazepam always lasted into the next week. I found 5mg of deschloroetizolam about as potent as your comparison to 8.5mg of diazepam, maybe I'd say more like 12mg or so but I'm specifically heavily affected by diazepam and derivatives for a reason I can only suspect to be metabolic quirks. I suspect that the lack of an R2 substitution may be to blame for this common effect, as deschloroetizolam, diazepam, bromonordiazepam, and actually also triazolam (which feels like this too, imo) all have an unsubstituted position at R2 (the bottom phenyl ring of the traditional 1,4-benzodiazepine scaffold).

 

[pcplease]

i have had weird and/or bad dreams, probably at least a night terror or two after deschloroetizolam but for the most part it feels to me like it impairs overall sleep far less than most or all other benzos. and i have used nearly all of the rcs extensively. and closer to 2mg deschloroetiz = 10mg diazepam for me

 

[dorian.927]

Thank you for your experience reports.
I wonder if the absence of halogen atoms in the molecule of deschloroetizolam could explain the lack of reliability in its effects, a bit like nitrazepam in some people.

 

[pcplease]

i could be wrong as we're talking over a decade ago now but i had thought something unique about etizolam itself was that it sort of floated around changing which bzd binding site (/ratios) it affects. which i would think tends towards varying effects for diff individuals. but i think theres a lot of variance w all of them tbh. few like alprazolam, seemingly etiz pretty consistently dopaminergic for most everyone

 

[funkalistic1]

What the heck is this ?

2-ethyl-9-methyl-4-phenyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine
Chemical Formula: C₁₇H₁₆N₄S
Molecular Weight: 308.40
m/z: 308.11 (100.0%), 309.11 (20.7%), 310.11 (5.0%), 310.12 (1.6%)
Elemental Analysis: C, 66.21; H, 5.23; N, 18.17; S, 10.40
CAS No. 40054-73-7
CBNumber: CB92681341

aka: Etizolam-2, deschloro-etizolam, 4-ethyl-13-methyl-7-phenyl-3-thia-1,8,11,12-tetraazatricyclo[8.3.0.0^2,6]trideca-2(6),4,7,10,12-pentaene

It looks like Etizolam without the Chlorine on the Benzene ring.

Any info on it ?
Any experience ?

Wikipedia article
older thread

Do yourself a favour and be very careful with the triazo benzodiazepines as they are much more potent than regular benzodiazepines and you will become dependent much quicker and let me tell you benzodiazepine withdrawal is more dangerous than almost any other type Except for delirium, Tremors or alcohol withdrawal you can actually die from it unlike opioids. benzos you can have seizures and die from the withdrawals so I would strongly suggest caution with thenio benzodiazepines, or triazalobenzodiazepines. They are up too 100x more potent and have NASTY withdrawal effects. Be cautious. Think on the potency level of Carfentanyl compared to OxyCodone or Demerol.

 

[4DQSAR]

Yeah - we went down the slightly different path of substituting etizolam for what we named 'metizolam' i.e. it lacked the 2-methyl. But in all other respects, both deschloroetizolam and metizolam appeared to be very similar (in the study we carried out).

Why metizolam? Because the Indian producer could simply swap the acetylhydrazine for formylhydrazine (in eqimolar amounts) thus until the last 2 steps, synthesis of metizolam and etizolam were identical. With deschloroetizolam one has to start with a different precursor and optimize more steps. So 'for ease' is, I think, the reason we went with it.

To be clear, this was when RCs were legal in the UK.

 

[pcplease]

i have never been able to source metiz in the us, but some deschloroetiz is still available. costly though as it hasnt been produced in a long time it seems. i liked fluclotizolam more than flubrotizolam, by far, but bulk fluclo disappeared before flubrotizolam. i think ive read positive clotizolam reports, and wanted to try it hoping for someting around etiz , fluclo was much stronger. deschloro is weaker by weight but a longer acting, less BZD-predictably, more drunkenly intoxicating effect and much longer acting. ived like them all for respective purposes.

 

[4DQSAR]

My guess is that since ALL benzos are now equally illegal, makers are simply looking for the biggest product. Sadly that's likely to be something like flunitrazolam - well, a nitrobenzodiazepine almost certainly. I don't claim to know why but I read about the intentional overdose cases in Sweden and noted that 100% of the deaths were from nitrazepam or flunitrazepam. The latter is much more potent so logic might suggest it to be safer, but for whatever reason, that doesn't appear to be the case.

I would be VERY cautious with any and all RCs on the market these days. Lack of proper competition has resulted in Grisham's law taking over. A maker HAS to make the most potent example because their competitor WILL and can then sell at a lower price...

All very worrying. By all means have fun - but nothing it worth the rest of your lives.

 

[pcplease]

i think a big part is lack of interest from people like you who are smart enough to figure out more novel synthesis. china doesnt produce them til a known easy synth is available- see their inability to produce pyrazolam despite heavy demand. instead we got 7-oh-phenazepam. flubromazepam from phenazepam, flubromazolam from that, and then we got bromazolam and now flubromazolam. phenazolam popped up on that swedish forum nearly a decade ago, IIRC.

phenazolam is incredibly potent, very long acting slow onset sold as alprazolam. fortunately not the rebound anxiety/withdrawal of clonazolam/clonitrazolam but 0.25mg is at least 10mg+ diazepam. bromazolam was pretty close and the new ethylbromazolam by reports it to be even more similar. i love it as a chem but it is absolutely not for novices. nitrazolam wasnt very popular. flubromazepam showed cardiotoxiciticy so that fact alone worries me they carry their own risks.

theres a pubmed case report listing cause of death by clonazolam alone from i believe someone really young like 14

 

[Octave77]

I've just noticed that etizolam, the chlorinated derivative of deschloroetizolam, is available on some RC vendors' websites again. This is quite an event. In a near future I would probably try etizolam so as to compare it with deschloroetizolam. But I don't know what is their equivalent potency on a milligram-to-milligram basis ; does anyone know it ?

 

[4DQSAR]

i think a big part is lack of interest from people like you who are smart enough to figure out more novel synthesis.

It's hard to know but it IS interesdting that not a single novel 1,5-benzodiazepine has turned up. The QSAR is a bit different but one most certainly could produce what I suppose might be called alprazam i.e. the 1,5 analogue of alprazolam. Swap the -Cl for an NO2- and yep, it doubles the activity in the same way it does for 1,4-benzodiazepines.

But years ago I was given a huge set of Annual Report in Medcinal Chemistry (softback) books and it seems that around the time benzodiazepines were discovered, other classes were also being developed and who knows why benzos 'won'?

 

[Dextro .45]

Etizolam 1mg
Deschloroetizolam 6mg

Two of the most Euphoric & pleasurable theinotriazolodiazepines ever synthesized. The benzodiazepines analog both having high affinity to the a2 & a3 subunits responsible for its anxiolytic properties

Etizolam is nearly better than Aplrazolam (Xanax) is the sense it’s robust anxiolytic & mood-boosting properties in addition to its significant antidepressant properties (due to Triazolo ring) like Alprazolam possesses

Deschloroetizolam 6mg is even BETTER than Etizolam and significantly more Euphoric and pleasurable …..both compounds have rapid onset of 20-30min with peak serum lever in an hour or less

 

[4DQSAR]

Etizolam 1mg
Deschloroetizolam 6mg

Two of the most Euphoric & pleasurable theinotriazolodiazepines ever synthesized. The benzodiazepines analog both having high affinity to the a2 & a3 subunits responsible for its anxiolytic properties.

YMMV. A lot of people appear to consider the nitrobenzodiazepines to be the most euphoric and it's quite likely that genetic differences and sought effects can explain those differences.

Are they particularly a2/a3 selective?

 

[dorian.927]

Thank you Dextro .45 for the equivalence etizolam 1mg deschloroetizolam 6mg. Did you try both of them and check this equivalence yourself ?

 

[Octave77]

Sorry I logged in wrong. I'm Octave77, not dorian.927, awaiting for your answer, thank you !

 

[Dextro .45]

sekio has a post showing the molecular structure side by side of deschloro etizolam vs etizolam and that analogy has been used to triazolam vs alprazolam or clonazepam vs nitrazepam, the expected effects were longer duration of effects and also an increase in dose, a ratio almost of 1 to 2mg to even as much as 1mg (etizolam) to 3mg (deschloro).

Since there weren't so many reports I decided to get some to shed some knowledge. I have experience with every benzo, Rohypnol & Triazolam aside, as well as the very new ones coming on the market. I take clonazepam for 11yrs at 5mg day but when I take other benzos in the equivalent dose of say 2mg K-pins be it valium, temazepam, midazolam, alprazolam...I can fell all even lorazepam, though 2mg is the most lorazepam one can day within 24hrs due to amnesic effects even if tolerant to benzos, reason why its used in hospitals so much, not as much for the relaxant effect since 1mg orally they give in surgery type operations isn't enough to take away the fear its there to make you forget.

I have experience with phenazepam which I even smoke via meth pipe (very stupid due to 'pyrolosis' -sp?- which is the cancer causing chemicals as soon as you heat the powder...vaporization by tin foil or otherwise). Since I take clonazepam daily I didn't mind oral phenazepam at all, rather prized it for its long lasting effects since I wasn't looking to get high like clonazepam can do if done with certain drugs but the primary effects of phenazepam are anxiolitic (so?) anti anxiety and also has anti convulsion;/epilepsy properties like K-pins do.

I've had the most experience with etizolam which is my favorite next to temazepam & alprazoalm but in a way better than xanax since it give me the onset of xanax with 80% valium and 20% temazepam effets, though different in that it makes me social, outgoing and energetic...and drumroll, without the memory loss of all benzos, phenazepam included.

As everybody I too was hoping for a better improved version of etizolam, I was thinking along the lines of dextroamphetamine vs methamphetamine where the methyl group makes it 2x longer. I knew it would take more for less intensity. I have two very expensive & reliable 0.000mg scales and I have a few friends who have those scales as well, a bit cheaper brands but reliable nonetheless. I usually take 4-6mg etizolam to feel good which I do after 10-15min so I didn't take any benzos the day I got the deschloro etizolam and weighted up 10mg which upon waiting 40min and smoking weed as well as taking my methadone. I re dosed after 45min another 15mg since I figured the ratio to etizolam wasn't the expected 2x, rather 3x so 1 figured 5mg like at 15mgs. I waited a good half hour to more and pissed off (should have left it alone) took another 20mg, waiting again over half hour and only getting extremely agitated since I got burned for good size amount of powder. I went though 80mg that day within 4-5hrs without feeling anything,

After 8hrs of fucking around with various redoses ended up using 75mg-78mg the first day, after which I took about 3-4mg etizolam from the same source as you can imagine I was feeling very agitated by this point. I ended up feeling okay & relaxed right away after the etizolam.

The second day I used 16mg deschloro etizolam to see if that would work and to my disbelief even that wasn’t anything, as in placebo to nothing in terms of effects, not even like 5-6mg etizolam or any benzo I can compare with. Maybe akin to very low doses of oxazepam which is my least favorite benzo, so I ended up re dosing again this time a generous 20mg which also didn’t hit me even after 45min.

I tried it once more with 30mg in one dose the day after and still I didn’t get anything even close to a benzo effect. Again a dose of 6mg-8mg etizolam is excellent for me which I took on top of the deschloro after 1.5hrs after ingestion and I felt it for sure, the etizolam that it.

Besides this I 3 friends who were interested in trying it and I gave them all about 10mg doses, about 3-4 doses each, 1 of the guys does not have a benzo tolerance meaning he doesn’t use everyday. Nobody including the guy without a benzo tolerance got any effects from it!

I have to conclude that it was either a. inactive or b. deschloroetizolam is the absolute worst garbage in the benzo world. I tried Demoxepam which is similar to nordiazepam and even that was better and to me it hold a spot not too far from phenazepam!

p.s. If this is the new replacement for etizolam you guys are all fucked! You can pay me and I still can’t say nothing positive about this drug! Never again!! A big waste! Waste of money, cost more than the equivalent dose of etizolam, waste of time & health above all!

If you're taking those large amounts of Deschloroetizolam the quality is piss poor

Etizolam 1mg
Deschloroetizolam 4-6mg (closer to 6)
Diazepam 10mg
Alprazolam 0.5mg
Diclazepam 1mg

I had the luck of acquiring near 100% purity pharmaceutical grade Deschloroetizolam HCL

a super fine beige coloured beach sand consistency HCL salt and would measure out with super accurate 2mg micro scoop

So I can fill jel cap with 2mg / 4mg / 6mg dosed caps mixed with MCC 101 excipient / bulking powder

Completely benzo naive adult male WOULD feel 2mg .....but for me, 4mg of Deschloroetizolam first time....it was VERY pleasant & euphoric, like floating on a cloud walking to the corner store. Amazing potent and rapid acting anxiolytic with antidepressant properties very similar to Alprazolam (Xanax)

I had both large quantities of Etizolam and Deschloroetizolam and its dechlorinated analog is far more pleasurable than Etizolam, which is amazing in its own right

Point being....I read alot of people trashing Deschloroetizolam or saying its bunk, or taking 30mg ......shiiiiiiit, if you had 100% purity pharma grade product, a single 6mg dose is easily 1.5mg of Xanax

Diazepam (Valium) & Alprazolam (Xanax) is hands down the ultimate benzodiazepine combo or single compounds.....that being said

Etizolam & Deschloroetizolam
Diclazepam (2-Chloro-Diazepam)
Avizafone (Pro-Diazepam)
Diazepam & Alprazolam

Best benzodiazepine compounds, paired with Oxycodone, Ritalin, Pregabalin and mixed drinks & cigarettes

Pure ecstasy ....in safe therapeutic doses tailored to one's tolerance

 

[Esperighanto]

If you're taking those large amounts of Deschloroetizolam the quality is piss poor

I just want to echo this hardcore, I'm a pretty heavy guy and have always been super GABA tolerant just naturally. I could distinguish 1-1.25mg of deschloroetizolam from placebo on blotter iirc (can't find my old notes binder right now but I'm pretty sure it was 1 or 1.25mg that I could notice). I did not give this to anybody else though, I preferred normal etizolam and was laying sheets of that shit back in the day.

 

[Dextro .45]

I just want to echo this hardcore, I'm a pretty heavy guy and have always been super GABA tolerant just naturally. I could distinguish 1-1.25mg of deschloroetizolam from placebo on blotter iirc (can't find my old notes binder right now but I'm pretty sure it was 1 or 1.25mg that I could notice). I did not give this to anybody else though, I preferred normal etizolam and was laying sheets of that shit back in the day.

Yes, totally plausible..... I am also kinda heavy ish 240 lbs 6" tolerant to all substances

I could differentiate between Deschloroetizolam 2mg, 4mg & 6mg with my micro scoop which was very accurate

I've just read countless threads on reddit etc people trashing Deschloroetizolam and saying 16mg they felt nothing and that has me thinking something is off with their product

Kern Spanish brand Diazepam 10mg is the best Valium on planet earth ....and my batches of Deschloroetizolam 15+ years ago were Extremely euphoric and the purest dechlorinated Etizolam molecule you'd ever find ....easily the most pleasant benzodiazepine analog ever

 

[hesus popescu]

alright, so i've been taken 10mg of descholoretizolam with 2 beers and its like roughly 0.5 of xanax.