Dermorphin?

[DrEIMiller]

Anyone ever heard of or better yet had any experience with the peptide called Dermorphin? Apparently, the one report I read about it said it's a great opiate high, not as good as IV heroin but somewhere in the range of oxycodone and hydrocodone. He only tried it orally in the 100-150mcg range.
Apparently it's listed as a opiate peptide mu agonist and best yet, it's not scheduled as far as I can tell.
Anyone got some more insight other than journals?

 

[tweetersig]

Originally posted by DrEIMiller:
Anyone ever heard of or better yet had any experience with the peptide called Dermorphin? Apparently, the one report I read about it said it's a great opiate high, not as good as IV heroin but somewhere in the range of oxycodone and hydrocodone. He only tried it orally in the 100-150mcg range.
Apparently it's listed as a opiate peptide mu agonist and best yet, it's not scheduled as far as I can tell.
Anyone got some more insight other than journals?
If I am thinking of the same thing that you are, it's about 25 dollars a mg, and is derived from frogs? Anywho, do a search on groups.google.com in the alt.drugs.hard archive. I recall a fairly in depth discussion of this peptide. It seems fairly easy to get online.

 

[Caleb's_Syde]

the only substance I have ever heard derived from frogs is that of 5-meo-dmt. Anyone else know what I am talking about?? The other day I read that this colorado something frog is available for purchase on the net.
L8ter

 

[quale]

a.d.h seems to have a split about whether taking it peripherally (i.e. not injecting it into your brain) actually gets you high. Some say yes (old old post) other more recent posts suggest no.
Someone needs to order some and try .

 

[tweetersig]

Originally posted by quale:

Someone needs to order some and try .
Hey, if I didn't think that my neighbors would steal my mail, I would. tis only 20-30 bucks for a mg. (doses range in micrograms.)

 

[PhreeX]

This is one I have been meaning to order for awhile.. there is a great online source that has it for $17 per mg, and as soon as I get a credit card I will order it and give a full trip report...
Anyway, since I used to post on ADH as much as I do here, I also have HUNDREDS of saved posts.... here is one that gives a quick rundown:
Production of antinociception by peripheral administration of
[Lys7]dermorphin, a naturally occurring peptide with high affinity for
mu-opioid receptors.
Author
Negri L; Lattanzi R; Melchiorri P
Source
Br J Pharmacol, 1995 Jan, 114:1, 57-66
Abstract
1. The opioid activity of the amphibian peptide, [Lys7]dermorphin,
was studied in rats and mice. When administered
intracerebroventricularly (i.c.v.), intravenously (i.v.) or
subcutaneously (s.c.) it produced a long lasting analgesia. Its
antinociceptive potency exceeded that of morphine 290 times by i.c.v.
injection, and 25-30 times by peripheral administration.
2. The dose-response curves of [Lys7]dermorphin antinociception
were shifted to the right by the pretreatment with naloxone (0.1 mg
kg-1, s.c.) or with the mu 1-selective antagonist, naloxonazine (10 mg
kg-1, i.v. 24 h before peptide injection).
3. The peptide also displayed potent antinociceptive effects in a
chronic inflammatory pain model (rat Freund's adjuvant arthritis). In
this pain model, systemic administration of the peptide raised the
nociceptive threshold more in inflamed than in healthy paw.
4. High central and peripheral doses of [Lys7]dermorphin in rats
produced catalepsy. The cataleptic response was antagonized by naloxone
but left unchanged by naloxonazine pretreatment.
5. In rats and mice, central or peripheral administration of
[Lys7]dermorphin induced a significantly slower development of tolerance
to the antinociceptive effect than did morphine.
6. Upon naloxone precipitation of the withdrawal syndrome,
[Lys7]dermorphin-dependent mice made fewer jumps and lost less weight
than the morphine-dependent animals. Withdrawal hyperalgesia did not
develop in
[Lys7]dermorphin-dependent mice.
7. In conclusion, [Lys7]dermorphin seems to be a unique opioid
peptide having a high penetration into the blood-brain barrier despite
its low lipid solubility. This peptide causes fewer side-effects than
other opioids and appears less likely than morphine to cause physical
dependence in rats and mice.
And here is a trip report from someone else....
Anyone who has done an opiate of any form already knows what to
expect. Having never done Morphine myself, I cannot comapare it
to Dermorphin, however it is supposedly 30-60x the potency when
taken orally, and 200-300x the potency when taken I.V. We
purchased 1mg for $20. Expensive, you say? Not really considering
that 1mg is apporx. 5-7 oral doses and 10 I.V. doses. If you
decided to inject the entire 1mg, you would die faster than
instantaneously. The high that Dermorphin gave me was just like
any other opiate I have ever done...warm, fuzzy, well-being,
euphoria (hic-ups, in my case), slightly itchy at times (I'm sure
you know what I mean). If you want me to compare it to something,
I would say think of a Hydrocodone or Oxycodone high and
multilply that by 500 or so...then you should have an idea. We
each took about 100-150mcg initially sublingualy. I felt the
first effects within 10 minutes...I was trying to figure out if
it was placebo or not, but after 30 minutes I knew my body had
just been ravaged by opiates. We all finished off the vile, so I
would assume that by the end up the night I ended up taking
200-259mcg total. The high lasted for appoximately 4-6 hours. It
wouldn't be foreign territory for the users of any opiate drug.
I'll tell you right now that it does not compare to H, so don't
expect that. But then again, I didn't take it I.V. The day after
I did Dermorphin, I decided to snort half a hit of H, and it's
definately more potent (nothing I would ruin my life over, mind
you. H takes you away from all your problems, which is why I can
see people getting [mentally and physically] addicted. But what
happens when you are off it? You're problems are still right
there. But it DOES feel frighteningly good Anyway, that's
about all I can tell you about Dermorphin...typical opiate
high....VERY potent...unscheduled by the DEA...available for
order from many research companies (although most of them don't
sell to individuals). I won't tell you any companies on here,
because the the last thing I want is for tons of people to order
it and O.D., as it is VERY potent. Then you would have ABC and
Hard Copy at your door with some horseshit like "New Designer
Drug-Dermorphin...the Legal Killer!" Heheh, sorry about that.
Besides, like I told you, 99% of the companies won't sell to the
public. Well, now you guys know about this particular
peptide...it IS orally active, it DOES pass the blood brain
barrier, and it is, basically, an opiate (although technically
it's not).
That's about it for my report. Hope this quenched your curiosity.
Like anything else, be careful when trying it, and enjoy! On a
final note, it makes people (myself included) feel so stupid for
trying to hookup Vicodin, Percodan, MS Contin, etc...we had this
shit staring us in the face the entire time. Ack. Oh well, later
for now....
Sorry about the formatting, it's all just C&P from old newsgroups postings (circa 1997)
OH, AND IF ANYONE EVEN ASKS ABOUT WHERE TO GET IT, YOUR ACCOUNT WILL BE SUSPENDED!

 

[SovietContin]

Where can I get some peptid... I mean, some pussy?

 

[meister]

Hmmmm hasnt it been linked to autism? Maybe that dose would fit on some blotter paper. Its supposedly somewhat hallucinogenic as well as being narcotic. It does fall in the category of "opiod peptides" so its sale by chemical companies maybe screened.

 

[day_for_night]

how the fuck does it come packaged??? you can't exactly scale out proper dosages when you only get 1mg. well you could, but you'd need access to about a thousand dollar scale. it has gotta come in solution...

 

[NoriegA]

Never heard of it. But after reading a little bit about it I want some. Seems real nice...

 

[DrEIMiller]

The post from ADH that Phreex posted was the only one I've seen so far and it made it look mighty interesting. Looks like it's pretty easy to find sources for it, but whether they will sell to individuals I dunno and I don't think I have the balls to find out. Though I would think that if it's really not a scheduled chem then they would sell to individuals? Or am I being naive?
Looks like it has some great recreational possibilities.....

 

[quale]

So that post was from 1997 and I saw a flurry of posts more recently claiming (though without much documentation) that it doesn't have recreational value. So I am really curious.
Ohh and it is apparently found in the urine of autistic children...so all of you really cheap bastards can just guzzle down some uring . This really doesn't mean much...they are always doing crazy things like finding DMT in skizophrenics urine. These are such large complex and poorly understood disorders it is really impossible to say whether something is a casual factor or merely a result of the disease.
I would be extremely interested (as someone on adh posted) to find out what the effect of naloxone on autistic children is. I bet there are at least singular reports of this.
So there are!! Here are some references.

Life Sci 2000 Aug 25;67(14):1667-82
Is there a basis for novel pharmacotherapy of autism?
Hunsinger DM, Nguyen T, Zebraski SE, Raffa RB.
--
J Autism Dev Disord 2001 Feb;31(1):103-8
Brief report: case reports on naltrexone use in children with autism: controlled observations regarding benefits and practical issues of medication management.
Williams PG, Allard A, Sears L, Dalrymple N, Bloom AS.
I don't appear to have access to that last source so would be interested as to anyone who might have online access to it if they could give a brief summary.
Anyway from the first article they note that the hypothesis regarding autism and opiates is that increased endrogenous opiates make the autistic individuals less response to the rewarding effects of social stimuls. They claim that while naloxone doesn't appear to work that great effects minor improvements are noted.
This suggests to me that while the autistic children might have higher endrogenous opiate levels this probably isn't the cause of their disorder (though of course might naloxone also block this reward system?). Also I am sucpiscious as long time heroin addicts don't seem to have similar problems to autistic children. Nor does it explain the apparent inability of autistic children to understand lies and build a model of anothers internal belief structure (i.e. autistic children given a situation where an object is hidden while another person is away from the room don't seem to be able to comprehend that the other individual will think the object is somewhere other than the place they think it will be).
[ 05 July 2002: Message edited by: quale ]

 

[meister]

It would be funny if they were sky high off abnormal levels of endogenous opiates. Collect their urine in vats, extract it and there you go.
I am not sure if dermorphin is recreational, and if so why this has yet to be capitalized upon. There are a number of other mu active opiod peptides, though dermorphin appears to be one of the more potent ones. Hmmmmm..........

 

[quale]

I think alot of the other peptides don't cross the BBB. Beta-endorphin has to be administered ICV I believe. As Dermorphin seems to be fairly lipid insoluble presumably it has to enter the brain via active transport *IF* peripheral administration really gets you high (one trip report from 97 contradicted by other claims doesn't convince me).
That would be quite interesting if it is actively transported across the BBB. I wonder where in the body it is produced then. Can we trick that organ into releasing it unnaturally?

 

[travis2600]

That post sounds like BS to me. Who else thinks that Heroin is 500 times as potent as oxycodone???
It appears to be easy for an individual to get, actually. But it sounds like it doesn't cross the BBB anyway.
Only one report on it, that sounds like BS, compared to many people saying it's not recreational. I guess it wouldn't be harmful to try yourself, but I wouldn't take the time personally.