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Bupe Day 3 of NO SUBOXONE--how many 10/325's is ok to take?

speedball820

Greenlighter
Joined
Mar 30, 2012
Messages
14
Location
West side Chicago
Hey all,
I'm on day 3 of no suboxone and am desperately (pathetic!) trying to catch an opiate buzz. I have a bunch of 10/325's hydrocodone. I took 5 this morning and it took away the sub w/d but caught only a tiny buzz. I just snorted 2 Adderall XR 25 mg and took 1 orally and dissolved one in water...and I'm not even feeling THAT! Wtf. Does Suboxone affect getting high off adderall too? I used to take adderall and feel mmm so good.
So I guess this is 2 questions...how many 0/325's is ok to take and what is going on with this adderall crap..

btw..I was down to 4 mg of sub for the last wk of taking it..which ended 3 days ago. im 155 lbs..woman...pretty healthy, other than the destructive shit I do to my body with these substances. Any ideas? :?
 
they wouldnt do shit to me and ive been on suboxone for yr.. the suboxone is so much stronger than tabs and definatly at a dose of 4 mg, you also have to factor in how long you've been taking it.. on top of the fact in my opinion and experience mixing uppers with opiates is just pointless, they cancel each other out.. meaning that your not going to really get the high from either one.. you'll still be awake minus the achey muscles and joints if the tabs will even do that much
 
I would have to take a minimum of 60mg oxycodone o feel it when I still have bupe in my system. and even then, it wouldn't be all that great of a high.

how much oxy do you normally have to take? double that and you will probably feel that. but then again, doing so is very dangerous and I don't recommend it, given all the risks (i.e. depressed breathing) involved with taking high doses of full agonist opioids.

And yea, no way to get around it. Actually, lol I think suboxone works awesome, for this exact reason (i.e. I know I won't be able to enjoy other opioids when I'm on it).

You can try potentiating your oxycodone with tagamet and benadryl, but that'll only do so much (still it would significantly help).

You're going to need to give yourself at least a week to let all the bupe get out of your system before you'll really be able to enjoy full agonist opioids again...
 
I've taken adderall on bupe many times w/ no problems.
If you're only on day 3, youre still well in the middle of WD. If you're actually trying to kick and stay kicked, doses around 10-20mg will ease the WD a bit, but only do this for a day or two. Any longer, and it'll just make things worse. You're gonna have a hard time getting high with any dose this close to stopping bupe.
Also, 4mg is pretty high amount to stop at. If you have the time and resources, you might want to reconsider tapering lower on your suboxone then try to stop.

(If you end up doing the hydrocodones anyway, don't forget to do a CWE if the dose contains more than 3g of APAP.)
 
Cold water extraction. Separates the tylenol from the hydrocodone. Too much tylenol and you'll be in extreme pain or even damage your live. 3g(3,000mg) is the most you should do in a day.

I just noticed they were the 325mg versions. So, you'd need to be doing 10 or more to do a CWE.
Just keep that in mind for the future. And some have 500mg so always check to see
 
thanks all. I looked up the cwe and am waiting for 4 pills to filter through my coffee filter. I took so many throughout today that my liver is probably in pain. I didn't know anything about CWE so thanks for the info. Still not catching any buzz... It's almost day 4 of no suboxone...maybe ill get something? I was only taking it for 2 weeks. How stuck on my MU receptors can it be? Being in Pharmacology in nursing school, my dumbass should know this...
any ideas?
Oh yeah, and do I add more water to the end product (the hydromorphone MINUS the tylenol)? I didnt put much water in it so it will be like less than the amount of a shot of liquor...
 
Hydrocodone really is pretty damn weak if you have been doing stronger Opiates for a long while. I have taken 200mg before and all it did was stop my Withdrawal. Not to mention it was stupid because of all the acetaminophen I took. (Was in Withdrawal hard and all I could find was Norcos)

I am on 4mg of Buprenorphine a day and I felt good taking 70mg of Methadone after only 36hrs off the Bupe.
 
Just take it. From experience...your going to get about 70% of the high. It will gradually fade over the next days and weeks. People here will tell you your not going to feel anything and blah blah but it's just simply not true. The half life seems like your fucked...on paper...when you actually experiment though it's a completly different story. And I been on them for 2 years.
 
Aww, you know what, just use the hydrocodone to get through the sub withdrawal. Take it when you feel bad, and don't try to catch a buzz, just try to feel straight. It takes about a full 2 weeks for suboxone to completely leave your system, so keep that in mind. If you only use the hydro's minimally to ease withdrawal, you should be able to get high in about a week.

Buprenorphine also screws up your receptors to a degree, so even after its gone from your system, it may take a while to get that old euphoria back. You might want to take a look at this thread, as it's similar to your predicament.

And amphetamines play upon totally different receptors in the brain than buprenorphine or other opioids do. You probably are feeling lousy still from being off the sub, which is why the adderall is not doing the trick.
 
Would I get an infraction if I just told this poor kid what hes doing wrong? I feel bad, but, then again, I don't necessarily want him getting high. I guess we should just : X and allow him to stay on the subs.
 
Why would you get an infraction for that? If you're so concern about it there's always private messaging.

It does take a substantial amount of time, ime generally about a week, for someone who's had bupe in their system (even at low an amount as 16mg taken over the course of only seven days) to be able to enjoy other full agonist opioids. And the weaker they are (hydrocodone, codeine, etc) the less chance there is that you'll feel them before all the bupe is out of your system. The stronger they are, the high will still be sginigicantly diminished until all the bupe if out of your system.

Be prepared to have to wait a minimum of 7 days to a maximum of 12 days for you to get high off stuff like oxycodone or hydrocodone OP. I doubt it'll take as long as 12 days, but I wouldn't be suprised if it took 7-9days since you last took suboxone to feel any other opioids effects significantly.

Btw, if you're only taking five or six pills that each have 325mg of apap in them (the total being 1950mg of apap), if you're young and you have a healthy liver, you don't really need to even deal with CWE.

That is, unless your liver is super fucked up all ready. For most people 1625mg or 1950mg of apap at once isn't a big deal. For most more than 2g, well, you're getting into dangerous territory. I mean, I've taken a shit load of apap more than once, and I won't even go into how much for the safe of harm reduction, but as my liver has been and still is in great shape, I wouldn't worry about <2g apap.

Then again, it's good to practice CWE and get good at it. Furthermore, better to be safe than sorry if you are unsure of the condition of your liver (or have a history of drinking a lot or being in an enviroment (i.e. around certain chemicals they use at the manicurist or in machine shops) were you are exposed to solvents and toxic chemicals over long periods of time).
 
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Would I get an infraction if I just told this poor kid what hes doing wrong? I feel bad, but, then again, I don't necessarily want him getting high. I guess we should just : X and allow him to stay on the subs.
The OP is female.

Always happy when people learn a little harm reduction.

Tho you made me cry about wasting hydromorphone. That is a definitely a crime.

She meant Hydrocodone, and I'm sure no one cares if boring old HC is wasted.

@ OP, You stopped suboxone at 4mg??? Way too high, but at least you didn't stop at 16mg or 24mg like some people who don't know that more is less with Subs. As it's been said, you should use the hydrocodone to ride out some of the WD you're going to have from jumping off at 4mg.
 
3 days off of suboxone is plenty of time to start taking opiates again, however remember suboxone not only blocks the efects of opiates when using it, it also jacks ur tolerance up big time, so even after 3 days off suboxone, u still have a mean opioid tolerance due to the potency of suboxone..
 
3 days off of suboxone is plenty of time to start taking opiates again, however remember suboxone not only blocks the efects of opiates when using it, it also jacks ur tolerance up big time, so even after 3 days off suboxone, u still have a mean opioid tolerance due to the potency of suboxone..

To say it blocks opioids and to say is "jacks up" your tolerance is the same thing. Your "high tolerance" after stopping taking suboxone is the just of the drugs high affinity to one's opioid receptors, coupled with the fact is has such a long half life. When you're actually on the drug, the reason if "blocks" opioids is the same - it's extraordinarily high affinity to your opioid receptors. Of course when it's at a high concentration in your system, as in when you're actually taking it, it will be better at blocking opioids than when it's slowly getting out of your system.

Somewhat nit picky distinction, but important nonetheless.

Regardless, for most people, it takes days and days before they can experience the true joy of full agonists, even after just using lower doses of suboxone a couple times.
 
i guess what i mean is, even after me going 3 days off suboxone, i still need hefty amounts of opiates for desired effects due to how potent bupe is as an opioid, partial agonist or not. and what i meant is taking suboxone just blocks the effects of opiates in general, so taking heroin the day u take suboxone uw ont achieve much of a high. in my experience...i have done heroin later in the evening and felt it, but not high, when i took a sub earlier, when i was off subs for 3 days, i felt the heroin alot more and enjoyable, but still i needed a hefty amt. of heroin cause of how much subs to raise ur tolerance even after its off ur receptors when blockage is not a problem
 
i guess what i mean is, even after me going 3 days off suboxone, i still need hefty amounts of opiates for desired effects due to how potent bupe is as an opioid, partial agonist or not. and what i meant is taking suboxone just blocks the effects of opiates in general, so taking heroin the day u take suboxone uw ont achieve much of a high. in my experience...i have done heroin later in the evening and felt it, but not high, when i took a sub earlier, when i was off subs for 3 days, i felt the heroin alot more and enjoyable, but still i needed a hefty amt. of heroin cause of how much subs to raise ur tolerance even after its off ur receptors when blockage is not a problem

Totally, this all makes sense, but notice your last sentence, "still i needed a hefty amt. of heroin cause of how much subs to raise ur tolerance even after its off ur receptors when blockage is not a problem." The suboxone is still attached to your receptors even after you've stopped taking it, and take a while (according to it's half life) to full dislodge from all of your receptors.

Over time, after stopping to take suboxone, more and more of it will fall off your receptors (gross oversimplification), therefore as the days pass since you last have taken suboxone the amount of dope you need to get high will decrease, until you're at your "normal" amount of dope.

I mean, in a sense, yea, it is raising your tolerance. However, the reason for suboxone "raising your tolerance" (what you really mean is "cross tolerance") is significantly different from why you develop tolerance (what I would characterize as a "true" tolerance) after beginning to use dope more and more often.

The reason you can't really get high of full agonists the day you stop taking you subs is basically the same reason for why you have to use much more dope to get high than you'd normally have to three days after you've stopped taking suboxone.

The reason you develop a tolerance after using dope more often is because you body is essentially getting used to the dopes effects/the fact there is opioids flooding your receptors from an outside source. The "tolerance" (to other opioids; so, again, technically you'd call it "cross tolerance") you have after taking suboxone is not created so much by the fact your body has gotten used to the suboxone (although this certainly plays a role, which is why I say in a sense your explanation is correct) as the fact that bupe has such an incredibly high affinity for your opioid receptors.

Does this make sense? All I'm trying to explain is that bupe's cross tolerance that interferes with getting high off other opioids does not play as significant of a rule preventing you from getting high like you normally would. What plays the significant role in preventing you from getting high as you might otherwise get is bupe's antagonist action/strong affinity for your opioid receptors.

Lol, I can't believe we're having such a heated discussion about something it seems like I essentially agree with you about (with one small caveat, of course). I would have made a good lawyer, alas :p

For an example of how anal I am when it comes to talking about suboxone, see:

NSFW:
Okay, this is kind of correct, but there are some minor and major mistakes.

The main and only practically significant drug in suboxone AND subutex is Buprennorphine, correct, although the way it is really spelled is "Buprenorphine." And yes, I like to be a dick whenever I get the chance =D

Yes, bupe is a mixed opioid agonist-antagonist. The following will explain the real meaning and significance of bupe being a mixed agonist-antagonist opioid.

What this means is basically that, in the sense that bupe is a partial opioid agonist, it will have some of your standard, morphine-like opioid effects (causing analgesia and euphoria for instance). Most, if not all, opioids used to treat pain or chronic pain are full opioid agonists, such as oxycodone. But remember, bupe, unlike oxy, is only partially an opioid agonist...

Thus, as it is only a partial agonist bupe's agonist properties, such as euphoria and analgesia, are not as pronounced as they are with a full agonist, such as oxycodone (thus people can easily catch a nice nod with oxy but it's rather hard if not impossible to do so with bupe, although it certainly will still make you feel damn good).

[The best known full opioid antagonist is Naloxone, best known as Narcan, which I discuss briefly a couple paragraphs below.]

In the sense that bupe is a partial opioid antagonist, thanks to its extreme high affinity (think of bupe a REALLY strong magnet) to your opioid receptors, it prevents (the vast majority) of other full opioid agonists (think of something like hydrocodone, for example, as a much weaker magnet) and full opioid antagonists (Naloxone/Narcan) from attaching to your receptors in significant numbers.

Bupe has such a high affinity for your opioid receptors that it will even kick off and dislodge previously attached full agonist opioids from your receptors. This is the cause of precipitated w/d (happens when you take bupe before all other agonist opioids are out of your system), and why you must wait 12-48hrs (depending on the full agonist opioid in your system) before you can begin taking and titrating your dose of suboxone/subutex.

Thus while bupe is in your system, it's antagonist action, thanks largely to it's extraordinarily high affinity to your opioid receptors, prevents other opioids from having much if any effect on you. But remember it's still only a partial antagonist, because as I mentioned previously it also has morphine like agonist properties.

That is why we call bupe a mixed/partial agonist-antaognist opioid. BTW, opioid means any morphine-like drug (as in chemical structure and/or effects).

For your average lay person all that takes a bit of thought to wrap your head around, but it's not really all that complicated to understand once you've figured it out.

Here's the big problem with your post: Suboxone/Subutex IS PRESCRIBED for pain managment in certain populations (i.e. if you're an addict and also suffer from chronic pain).

Naloxone is the drug in Narcan, which alone, as a full opioid antagonist, is used to treat people who have overdosed on opioids. Naloxone is thought to deter abuse of suboxone (it's not in subutex), however it does little to nothing to actually do so. This is because the bupe in the suboxone renders it useless, out-competing the naloxone. The bupe in suboxone just doesn't give the naloxone any chance to attach to your opioid receptors.

(Narcan is also used to treat bupe overdoses, rare though they might be given it's ceiling effect, but you have to use much more Narcan than you normally would when treating someone who has overdosed on a full agonist; Narcan will probably have to be administered multiple times as well to treat a bupe overdose.)

(Notice how, with a big enough dose of Narcan you can treat a bupe overdose, just as how you can get high while taking bupe as long as you use a big enough dose of a full agonist?)

Thus, it doesn't really make a BIG difference whether you're on suboxone or subutex. Doctor's mistakenly believe that it's the naloxone in the suboxone that makes it "abuse proof," when this is absolutely not the case (as the naloxone doesn't really do anything, unless you're allergic to it I mean, and in that case you also will probably be allergic to the bupe itself). People can still shoot, snort, plug or take suboxone however they please. In terms of pain management, both suboxone and subutex work pretty much as well as one another.

Taking full agonist opioids (hydrocodone, oxycodone, morphine, hydromorphone, etc. etc.) while on suboxone or subutex is highly impractical. To do so effectively you'll need to take many times your normal dose to achieve any effect (because the bupe is out competing them, thus blocking and preventing them from attaching to your opioid receptors in significant numbers), and as Zneg notes such high doses can pose risks to the user themselves. (That being said, I have been able to get high from both heroin and oxycodone by taking much, much more than I normally would have while I also had bupe in my system.)

But given bupe's ability to treat many forms of chronic pain, other opioids are generally not needed for pain management when a patient is using bupe. Tramadol is often prescribed in conjunction with bupe, as it does not work like classic opioids and thus is not affected by the bupe. Of course if you need some sort of medication to treat break through pain that is stronger than what tramadol can handle, you can work out a viable option/dosage of suboxone/subutex to make another opioid possible (I believe there are other opioids with an affinity to your receptors that comes pretty close to if not surpassing bupe's affinity).

The best point in the above quote is that suboxone/subutex should only really be used by those who plan to stay the course, and use it long term. It is not the kind of drug that lends itself to just taking once in a while to treating chronic pain, although I do know one individual who's successful for the most part in so using it.

By the way, although most do not get "high" from it after the first day or two they're on it, many do feel a positive, analgesia and euphoria from suboxone/subutex EACH AND EVERY time they take it (such as myself). So until you try it out and get used to it, you can't really predict how well it will work for you. But honestly this goes for ANY and EVERY drug...

Again, I want to emphasize, bupe is a great tool at treating chronic pain in certain populations (especially those who have chronic pain and are also former opioid addicts or habitual abusers of their pain meds). Of course it doesn't work as well for everyone, and its efficacy at managing chronic pain will depend largely on the type and severity of your symptoms. But this is for your and your doctor to work out.

Altered Perception: My friend, please use the edit function to add to your preexisting post instead of just creating a whole new post in the future. Double, triple and especially quadruple and quintuple posting is frowned upon for a variety or reason (namely it forces one to scroll more than necessary).

Shit, when I get going about suboxone, I sure do get going...
 
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