Tryptamine*Dreamer
Ex-Bluelighter
I could not find any open threads on this topic, and I think maybe it deserves more discussion in the name of harm reduction. I opened this thread so anyone who has experienced life threatening side effects from a drug combo or knows someone who has (especially if the person died from it) can post about it.
Looking for ANY dangerous combos of drugs, including reactions between psychoactive and non psychoactive drugs.
Since my post is long, I will put the names of combos in bold so you can easily skip what you don't want to read.
I have done two combos before that I think had me near death - DXM+Ephedra (most people know not to mix DXM and stims. I did too but I ended up completely out of my head and OD'd on ephedra) and HBWR seeds+MDMA (I don't think this one is a well known bad combo). I'll describe the effects of both. Edit: Thought I'd add another bad experience, this one a combo of MDPV, bupropion, and selegiline(a MAO-B inhibitor) Also adding a warning on fluoxetine's and its active metabolites extremely long half lives/how long it could be till you can use MAOIs after you quit. The normal two week wait seems very insufficient. Fluoxetine/Prozac is a very common medication and many psychedelic users use MAOIs. Seeing how dangerous a SSRI+MAOI combo is I thought it was worth including.
DXM+Ephedra - About 8 years ago - This was my first time ending up in any kind of serious medical trouble due to drugs, or better put, doing something really stupid with drugs. I had been wanting to experience a 4th plateau DXM trip. I initially took 1.5g of DXM powder, which was about the minimum I calculated it would take to get what I wanted. About 3 hours pass and I am feeling like I might fall asleep but I'm not tripping. I go take like a couple of 25mg ephedra pills and add about 250mg more of DXM. Maybe an hour later, I am very intoxicated but still not really tripping. I am afraid I'll fall asleep and miss the trip or else that the DXM just won't work as usual. I take some more ephedra pills. Some more time passes. By now, I am tripping with good visuals with eyes closed and I am losing touch with reality with everything seeming like a dream. I no longer realize that taking more drugs could be extremely dangerous. I go take more ephedra and decide to add a small amount - probably 50-75mg at most - of DXM because I still think it is not going to get me to the 4th plateau which maybe you can understand seeing as it had been like five hours since initial dose. Some more time passes. Now I am completely out of my mind and it seems like my body is doing things without any control from my brain. It also seems like I am partly out of body just watching a movie or something. At this point I start popping a lot of ephedra pills, taking more every few minutes. I really did not know what I was doing. Soon I am on the way to the ER and I try to get out of the car on the way while it is moving but someone stopped me. My mom told me later that my blood pressure was about 300/200 when I arrived at the ER. I was apparently having trouble breathing also. Small blood vessels bursted in my retinas. I was given sodium nitroprusside to quickly lower my blood pressure. I was taken to the ICU and asked if I wanted a priest to give last rights, this was the first time I knew I was in the hospital. I looked up at the blood pressure monitor and saw a number well above 200 and thought it was my heart rate. Few people survive blood pressures that high. Those who have severe hypertension though can withstand higher blood pressures than most and when I went to the doctor a week later with nothing but benzos and I think an opiate in my system and my blood pressure was above 190/120. If this happened to someone with a more normal BP it would probably kill.
HBWR+MDMA - About 3 years ago - I decided I'd like to mix a modest dose of MDMA with a lower end (for me) dose of HBWR seeds. Exact number of seeds I don't remember but it was probably 10-12. I would normally take 16-20 of them. I took the HBWR seeds first. I had just under 75mg of MDMA which I was going to snort when the HBWR kicked in fully. By that time my sinuses were really clogged and my face was hurting but not too bad. I thought about saving the MDMA for later but ended up plugging it. Within 10 minutes, my face was in lots of pain from the sinuses. Then things really went downhill. Another 5 minutes or so and I was starting to feel really hot and my heart started beating harder and faster. A few more minutes and I was pouring sweat to the point that my clothes were pretty soaked. My heart was now beating harder and faster than ever before. I felt like I was not getting enough oxygen. I am sure my blood pressure was extremely elevated as I could feel blood pumping through parts of my body that I had never felt it in before. My head started hurting bad. It was a severe pulsing pain and I felt pressure in my head with each pulse of pain. I think the pulses of pain were caused by the blood pumping through my head much harder than it is supposed to. I felt really lightheaded and dizzy. I was sure I would die. Thank god MDMA wears off pretty fast. As it started to wear off significantly, I felt I had cheated death. My eyes feel really strange, my throat and penis hurt, and it is hard to swallow. I go to the bathroom mirror and am shocked by the extreme swelling of my upper eyelids. Only a small slit of my eyes are visible and I can't come close to opening them halfway even when I open them as wide as possible. Much of my face is swollen slightly-moderately depending on the part. I check my throat and it is really red and the hole going down to the esophagus and trachea at the back of my throat is constricted. My tongue looks kind of reddened and appears slightly swollen. The head of my penis is a bit swollen and my foreskin looks like twice as thick as normal. I assume my blood pressure may have got so high that blood vessels leaked or burst and caused all that swelling. I think I may have had serotonin syndrome.
MAOI dangers and a note on the extremely long half life of the SSRI fluoxetine/Prozac (4-6 days) and its active SSRI metabolite norfluoxetine (4-16 days)
I should not have to point this out, but there are SO many things that interact very severely with MAOIs, so make sure if you do ayahuasca or anything else with MAOIs that you make sure you have nothing in your system that will interact with them. Be sure you know the half life of any recently used meds. Some meds have very long half lives exceeding two weeks.
Potential danger of MAOI interaction with fluoxetine/Prozac - this SSRI could remain in your system in significant amounts for far longer than two weeks
I've never done this, it is just an example. You are supposed to wait at least two weeks after using an SSRI before using an MAOI but the SSRI fluoxetine (Prozac) has an average half life of 4-6 days with long term use and I am not sure two weeks would be enough for it to clear your system completely, especially if you are on a high dose and/or you metabolize it more slowly than normal. Even worse, it has an active SSRI metabolite, norfluoxetine, which was being developed as another SSRI antidepressant but never reached the market. Norfluoxetine has a highly variable half life of 4-16 days. So you could have high levels of this active metabolite for far longer than two weeks. With its half life being as long as 16 days, it could easily take well over a month after stopping fluoxetine before an MAOI could safely be used. Also, I read an article that said it takes 25 days for 90% of fluoxetine/Prozac to be eliminated from the body. If that is right, doing an MAOI two weeks after quitting that drug could probably kill. I am pretty sure this does not apply to selective inhibitors of MAO-B such as selegiline since MAO-A is responsible for serotonin metabolism. Unfortunately, inhibitors of MAO-A are required for psychedelic potentiation.
MDPV+bupropion+selegiline - Another dangerous combo I tried
I did mix selegiline with MDPV and bupropion/Wellbutrin maybe two years ago and it caused my blood pressure to exceed 200/130 at its highest. This was a lot higher than it has ever been from MDPV with or without bupropion. MAO-B metabolizes dopamine. Bupropion is both a reuptake inhibitor and a releaser of dopamine. I'm not completely sure about MDPV but with its similarity to methylphenidate, MDPV probably shares its dopamine reuptake inhibitor and dopamine releasing properties. The highest my BP has been on stimulants without selegiline is about 180/114 and I was extremely anxious when it was measured (that was the last time I had an MDPV analog a few months ago). A blood pressure of 200/130 is getting into the danger level. I knew better than to take an MAOI with those things but unfortunately did not realize selegiline was an MAOI at the time. I read somewhere about its use as a nootropic and nowhere did it mention that it was an MAOI. From this experience, I would say mixing any MAOI with reuptake inhibitors and/or releasers of dopamine is dangerous. This goes for those selective for MAO-A as well because it also metabolizes dopamine as well as norepinephrine and serotonin which makes them even worse.
If anyone has experienced life threatening effects from bad combos, especially unusual combos or ones not widely known to be or regarded as dangerous, please post.
Looking for ANY dangerous combos of drugs, including reactions between psychoactive and non psychoactive drugs.
Since my post is long, I will put the names of combos in bold so you can easily skip what you don't want to read.
I have done two combos before that I think had me near death - DXM+Ephedra (most people know not to mix DXM and stims. I did too but I ended up completely out of my head and OD'd on ephedra) and HBWR seeds+MDMA (I don't think this one is a well known bad combo). I'll describe the effects of both. Edit: Thought I'd add another bad experience, this one a combo of MDPV, bupropion, and selegiline(a MAO-B inhibitor) Also adding a warning on fluoxetine's and its active metabolites extremely long half lives/how long it could be till you can use MAOIs after you quit. The normal two week wait seems very insufficient. Fluoxetine/Prozac is a very common medication and many psychedelic users use MAOIs. Seeing how dangerous a SSRI+MAOI combo is I thought it was worth including.
DXM+Ephedra - About 8 years ago - This was my first time ending up in any kind of serious medical trouble due to drugs, or better put, doing something really stupid with drugs. I had been wanting to experience a 4th plateau DXM trip. I initially took 1.5g of DXM powder, which was about the minimum I calculated it would take to get what I wanted. About 3 hours pass and I am feeling like I might fall asleep but I'm not tripping. I go take like a couple of 25mg ephedra pills and add about 250mg more of DXM. Maybe an hour later, I am very intoxicated but still not really tripping. I am afraid I'll fall asleep and miss the trip or else that the DXM just won't work as usual. I take some more ephedra pills. Some more time passes. By now, I am tripping with good visuals with eyes closed and I am losing touch with reality with everything seeming like a dream. I no longer realize that taking more drugs could be extremely dangerous. I go take more ephedra and decide to add a small amount - probably 50-75mg at most - of DXM because I still think it is not going to get me to the 4th plateau which maybe you can understand seeing as it had been like five hours since initial dose. Some more time passes. Now I am completely out of my mind and it seems like my body is doing things without any control from my brain. It also seems like I am partly out of body just watching a movie or something. At this point I start popping a lot of ephedra pills, taking more every few minutes. I really did not know what I was doing. Soon I am on the way to the ER and I try to get out of the car on the way while it is moving but someone stopped me. My mom told me later that my blood pressure was about 300/200 when I arrived at the ER. I was apparently having trouble breathing also. Small blood vessels bursted in my retinas. I was given sodium nitroprusside to quickly lower my blood pressure. I was taken to the ICU and asked if I wanted a priest to give last rights, this was the first time I knew I was in the hospital. I looked up at the blood pressure monitor and saw a number well above 200 and thought it was my heart rate. Few people survive blood pressures that high. Those who have severe hypertension though can withstand higher blood pressures than most and when I went to the doctor a week later with nothing but benzos and I think an opiate in my system and my blood pressure was above 190/120. If this happened to someone with a more normal BP it would probably kill.
HBWR+MDMA - About 3 years ago - I decided I'd like to mix a modest dose of MDMA with a lower end (for me) dose of HBWR seeds. Exact number of seeds I don't remember but it was probably 10-12. I would normally take 16-20 of them. I took the HBWR seeds first. I had just under 75mg of MDMA which I was going to snort when the HBWR kicked in fully. By that time my sinuses were really clogged and my face was hurting but not too bad. I thought about saving the MDMA for later but ended up plugging it. Within 10 minutes, my face was in lots of pain from the sinuses. Then things really went downhill. Another 5 minutes or so and I was starting to feel really hot and my heart started beating harder and faster. A few more minutes and I was pouring sweat to the point that my clothes were pretty soaked. My heart was now beating harder and faster than ever before. I felt like I was not getting enough oxygen. I am sure my blood pressure was extremely elevated as I could feel blood pumping through parts of my body that I had never felt it in before. My head started hurting bad. It was a severe pulsing pain and I felt pressure in my head with each pulse of pain. I think the pulses of pain were caused by the blood pumping through my head much harder than it is supposed to. I felt really lightheaded and dizzy. I was sure I would die. Thank god MDMA wears off pretty fast. As it started to wear off significantly, I felt I had cheated death. My eyes feel really strange, my throat and penis hurt, and it is hard to swallow. I go to the bathroom mirror and am shocked by the extreme swelling of my upper eyelids. Only a small slit of my eyes are visible and I can't come close to opening them halfway even when I open them as wide as possible. Much of my face is swollen slightly-moderately depending on the part. I check my throat and it is really red and the hole going down to the esophagus and trachea at the back of my throat is constricted. My tongue looks kind of reddened and appears slightly swollen. The head of my penis is a bit swollen and my foreskin looks like twice as thick as normal. I assume my blood pressure may have got so high that blood vessels leaked or burst and caused all that swelling. I think I may have had serotonin syndrome.
MAOI dangers and a note on the extremely long half life of the SSRI fluoxetine/Prozac (4-6 days) and its active SSRI metabolite norfluoxetine (4-16 days)
I should not have to point this out, but there are SO many things that interact very severely with MAOIs, so make sure if you do ayahuasca or anything else with MAOIs that you make sure you have nothing in your system that will interact with them. Be sure you know the half life of any recently used meds. Some meds have very long half lives exceeding two weeks.
Potential danger of MAOI interaction with fluoxetine/Prozac - this SSRI could remain in your system in significant amounts for far longer than two weeks
I've never done this, it is just an example. You are supposed to wait at least two weeks after using an SSRI before using an MAOI but the SSRI fluoxetine (Prozac) has an average half life of 4-6 days with long term use and I am not sure two weeks would be enough for it to clear your system completely, especially if you are on a high dose and/or you metabolize it more slowly than normal. Even worse, it has an active SSRI metabolite, norfluoxetine, which was being developed as another SSRI antidepressant but never reached the market. Norfluoxetine has a highly variable half life of 4-16 days. So you could have high levels of this active metabolite for far longer than two weeks. With its half life being as long as 16 days, it could easily take well over a month after stopping fluoxetine before an MAOI could safely be used. Also, I read an article that said it takes 25 days for 90% of fluoxetine/Prozac to be eliminated from the body. If that is right, doing an MAOI two weeks after quitting that drug could probably kill. I am pretty sure this does not apply to selective inhibitors of MAO-B such as selegiline since MAO-A is responsible for serotonin metabolism. Unfortunately, inhibitors of MAO-A are required for psychedelic potentiation.
MDPV+bupropion+selegiline - Another dangerous combo I tried
I did mix selegiline with MDPV and bupropion/Wellbutrin maybe two years ago and it caused my blood pressure to exceed 200/130 at its highest. This was a lot higher than it has ever been from MDPV with or without bupropion. MAO-B metabolizes dopamine. Bupropion is both a reuptake inhibitor and a releaser of dopamine. I'm not completely sure about MDPV but with its similarity to methylphenidate, MDPV probably shares its dopamine reuptake inhibitor and dopamine releasing properties. The highest my BP has been on stimulants without selegiline is about 180/114 and I was extremely anxious when it was measured (that was the last time I had an MDPV analog a few months ago). A blood pressure of 200/130 is getting into the danger level. I knew better than to take an MAOI with those things but unfortunately did not realize selegiline was an MAOI at the time. I read somewhere about its use as a nootropic and nowhere did it mention that it was an MAOI. From this experience, I would say mixing any MAOI with reuptake inhibitors and/or releasers of dopamine is dangerous. This goes for those selective for MAO-A as well because it also metabolizes dopamine as well as norepinephrine and serotonin which makes them even worse.
If anyone has experienced life threatening effects from bad combos, especially unusual combos or ones not widely known to be or regarded as dangerous, please post.
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