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Misc CYP1A2 And CYP2B6 Inhibitors

Thomas29

Thomas29

Bluelighter
Joined
Oct 25, 2010
Messages
1,505
I Need to know what CYP2B6 I can't find Any I can get Access to Oh Well..... Just Checking I Am Always thorough. I have Fluoxetine which I Believe is Prosac But I don't know if even using it Once a Month would have Side-Effects as I will Not take it Everyday.
 
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I take prozac every day as an anti-depressant, It gives me on and off results, wierd tunnel vision and hallucinations at times. i don't think it inhibits CYP2B6, but i know for sure it does inhibit CYP1A2 along with a few other SSRI's. Also note that prozac stays in your system for 3 days, so your good for awhile after taking it, if this is your only goal.
 
Yes I want to Inhibit CYP1A2 But Cimitedine also does it Weakly should it be Sufficient enough I usually Take a 1000MG Of Cimetidine 1 Hour before Dosing An Opioid/Opiate/Benzodiazepine whatever Drug I Am Doing at the Time. Do you think Taking Prosac Once a week Or Once a Month Or anything But everyday should Be Avoided and Or there are Better Inhibitors Or Does Cimitedine's Inhibtion Depend on Dose AND SUBSTANCE?


Anti-Depressants in General SCARE TH FUCK OUTTA ME with the Withdrawals and the TOTAL WIDE-RANGE OF EFFECTS AND UNPREDICTABILITY BETWEEN PATIENTS. It Feels Like as if your Re-Wiring your Brain because you can't even take MDMA on the Shit without Serotonin Syndrome for Me I just Do Not Feel I need it I was Very Depressed and I think Opioids Might be Masking it A BIT but I am Mostly over the shit. Time Heals Physically and Mentally it can also Damage you if Time is Not Used Properly GET SLEEP EVERYONE 8 HOURS HIGH-QAULITY shit.... I am taking 60MG Temazepam 1 hour before Bed I heard 10% of it is Metabolized Via CYP3A4 and it BARLEY BUT STILL SLIGHTLY Effects your Sleep Architecture and Quality this is Totally off-topic though lol.
 
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Crushed :)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805389/

That case report describes cimetidine roughly tripling plasma levels(mg per mg), of um, clozapine.

Also, white grapefruit juice is a damn potent CYP1A2 inhibitor, at high doses, of course you have to be willing to down the whole bottle.

As usual, WGJ and cimetidine are the best OTC inhibitors. As for 2B6, good luck, they're aren't any commonly available inhibitors I know of.(orphenadrine, but isn't that POM?)

Why do you want to inhibit 1a2 and 2b6 anyway? "Opioids and benzo's" are almost exclusively 3A4/2D6 selective( well, the P450 substrates anyway.)
Plenty of inhibitors for those. Only Valium and methadone are 1A2 substrates off hand, but methadone is metabolized by 5 different enzymes(at least) and for diazepam, inhibition just doesn't seem to be effective.(clonazepam, but again, it's primarily 3A4.)

Depending on the drug, drink at least 1 liter of WGJ(preferably 2) 800mg cimetidine, you're good to go.
 
2B6 for Methadone I have Done Orphenadrine and can get it OTC as A Muscle-Relaxer But I don't think it's something to Be Used even Weekly.
 
I used to drink a liter or so of white grapefruit juice before dosing dextromethorphan, so it's possible that taking a therapeutic dose (30-60mg) of DXM would be an adequate substitute as they interact with the same enzymes (although I have not tested this). In my experience, however, trying to potentiate opiates with cimetidine worked somewhat, but also caused me to get the jitters and suffer an anxiety attack. Grapefruit juice works pretty well, but as Lorne??? said above you would have to drink pretty much a whole 2 liter bottle, and if you don't like grapefruit juice it's a pretty nauseating task.
A method that I have found rather effective (and delicious) is to eat a high fat meal with your opiates. I don't know the exact science behind it -- and it probably has nothing to do with CYP inhibitors -- but I used to eat one of those Banquet sausage and gravy pot pies after I took my oxy... talk about potentiation =D It made me feel like I took a whole 80 when I had only taken 40.
 
herb.green said:
I used to drink a liter or so of white grapefruit juice before dosing dextromethorphan, so it's possible that taking a therapeutic dose (30-60mg) of DXM would be an adequate substitute as they interact with the same enzymes (although I have not tested this). In my experience, however, trying to potentiate opiates with cimetidine worked somewhat, but also caused me to get the jitters and suffer an anxiety attack. Grapefruit juice works pretty well, but as Lorne??? said above you would have to drink pretty much a whole 2 liter bottle, and if you don't like grapefruit juice it's a pretty nauseating task.
A method that I have found rather effective (and delicious) is to eat a high fat meal with your opiates. I don't know the exact science behind it -- and it probably has nothing to do with CYP inhibitors -- but I used to eat one of those Banquet sausage and gravy pot pies after I took my oxy... talk about potentiation =D It made me feel like I took a whole 80 when I had only taken 40.
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TRYING MY BEST NOT TO BE RUDE But.... I did NOT MENTION A SINGLE FUCKING THING ABOUT DRINKING GRAPEFRUIT JUICE I Mentioned EATING ONE GRAPEFRUIT AN HOUR BEFORE AND SINCE YOU ALL NEED EVERY SINGLE LITTLE BREATHE OF DETAIL OF MY QUESTION IN ORDER TO GET AN ANSWER FROM YOU CAUTIOUSLY CURIOUS CATS ON BLUE-LIGHT.ORG LOL!



I Take ONE 100% Natural Naringin 500 mg 60 Caps SINCE I CAN'T LINK SOURCES AND OF COURSE Citrulife Lower Cholesterol Naturally with Bergamot Fruit Which ALSO CONTAINS 500MG EXCEPT It's Bergamot and Of Course ONE MORE Inhibitor in Grapefruit and PROBABLY MORE HAVE NOT BEEN ISOLATED EXTRACTED IN PILL FORM OR DISCOVERED YET SAME WITH BLUEBERRIES AND THEIR ANTI-OXIDANTS THERE COULD BE A VITAMIN-Z THAT FUCKING HEALS LUNG CANCER or some shit in HIGH ISOLATED PILL DOSES NOT MASS AMOUNTS OF EATING BLUE BERRIES FUCK!!!


Anyways I take One 500MG Bergamot Pill a Day with One 500MG Naringin Pill When EATING ONE WHOLE ACTUAL GRAPEFRUIT NO JUICE GRAPPPEEFFFRUIITT NOOOO JUICE N-O JUICE NON-EXISTANT GRAPEFRUIT JUICE DRINKING ONLY ONE GRAPEFRUIT ACTUAL FRUIT AND PILLS FROM SHIT THATS INSIDE GRAPEFRUIT DO YOU PEOPLE UNDERSTAND!?!?!?! MY QUESTION WE ALREADY ANSWERED OR ARE YOU DONE TELLING ME WHAT I ALREADY KNOW SO I CAN BLOW YOUR MIND WITH WHAT I KNOW!

NOW LET'S MOVE ON TO SOMETHING PRODUCTIVE AND SOMETHING I DO NOT KNOW ABOUT ORPHENADRINE AN OVER-THE-COUNTER MUSCLE-RELAXER IN Canada, Ontario I can Buy it and it Inhibits CYP2B6 But what are the Side-Effects is it Safe to Take Everyday or only ONCE A WEEK or ONLY ONCE A MONTH????
 
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Thomas29 said:
TRYING MY BEST NOT TO BE RUDE
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Then maybe you shouldn't type in all caps. All caps is usually interpreted as yelling, which is usually, you know, rude.

If you are simply looking for a CYP1A2/2B6 inhibitor, then why are you jumping straight to antidepressants and muscle relaxers? Why not stick to something simpler and with less side effects like Tagamet/naringin/grapefruit?
 
herb.green said:
Then maybe you shouldn't type in all caps. All caps is usually interpreted as yelling, which is usually, you know, rude.

If you are simply looking for a CYP1A2/2B6 inhibitor, then why are you jumping straight to antidepressants and muscle relaxers? Why not stick to something simpler and with less side effects like Tagamet/naringin/grapefruit?
Click to expand...





Can I get SOMEONE WHO KNOWS WHAT THEY'RE TALKING ABOUT I AM USING CAPITALS TO MAKE IT MORE APPERENT AND EASIER TO READ..... Sorry some Arguably Illiterate Individuals Interpret that as YELLING ON THE INTERNET LOL!



Tagamet IS A BRAND NOT A SUBSTANCE MOSTLY REFERRED CIMETIDINE BRAND TAGAMET.... Caps-Lock OFF!: BTW EXCLAMATION MARKS IS! YELLING! JUST! SO! YOU! KNOW! I Purchase Generic Equate Brand MUCH CHEAPER then the Unnecessarily EXPENSIVE TAGAMET and Naringin ONLY INHIBITS CYP3A4 MAYBE CYP1A2 But I Do Not Know and Grapefruit has Narngin In it ONLY THE OVER-THE-COUNTER MUSCLE RELAXER IN MY LOCATION SELLS a CYP2B6 Inhibitor A Muscle-Relaxer Orphenadrine which can Act as a Stimulant Unlike Most Muscle-Relaxer you Risk No Respiratory-Respiration To My Knowledge probably so little it doesn't matter because no WARNING WAS ON THE PACKAGE EXCEPT POSSIBLE TO CAUSE INSOMNIA IN SOME PEOPLE AND TO ONLY Dose in the Morning Perfect for Methadone I Am thinking 4 Days And Doses Every 30 Days Or One Dose Every 7 Days LET ME KNOW SOME USEFUL INFORMATION PLEASE PEOPLE!!!!



I Need to Know How well Naringin And Bergamot Inhibit CYP1A2 Rendering Fluoxetine:Brand Name - Prosac Pointless Also What Dose Of Clarithromycin Inhibits CYP3A4 I Am Prescribed 250MG In the Morning and 250MG at Night for 3 Months and some people Say you Need 500-1000MG My Doctor Only Gave Me 250MG Because I Was Worried About Side-Effects and He said it was a Low Dose And should Not Matter But He would give me 500MG Once In Morning Or Once a Night Or even 1250MG or a 1000MG It Might Be Twice A Day Once In Morning Once Later Closer To Night Time. OR MAYBE I SHOULD CREATE A NEW THREAD FOR THESE COMPLICATED QUESTIONS WITH A DIFFERENT TITLE TO ATTRACT MORE PEOPLE WITH KNOWLEDGE ABOUT ALL OF THIS.


I also Need to Know if Eating One Grapefruit NO JUICE Is More Potent than The Juice which May have Expired And Or Destroyed the Bergamot and Naringin Over-Time also is 500MG Of Bergamot and Naringin an Hour before Dosing SUFFICIENT Or Should I Double it to what the Bottle Says 2 Pills Twice A Day Before Meals So would a 1000mg Of Each Be Better.... Don't Tell Me there Is NO WAY TO KNOW BECAUSE YOU SEEM TO KNOW THAT YOU GOTTA DRINK A WHOLE FREAKING 2 LITRES OF GRAPFERUIT JUICE FOR IT TO BE A POWERFUL INHIBITOR WHY IS THAT BECAUSE THAT'S HOW MUCH JUICE IT TAKES FOR HOWEVER MANY MGs Of Bergamott,Naringin and A 3rd Not Yet ISOLATED Supplement Form Inhibitor Hence I still Eat One Whole ACTUAL GRAPEFRUIT REMEMBER I DRINK NO JUICE WHO KNOWS WHAT OTHER INHIBITORS IT GOT.


Any Details I Am Forgetting For All you THREAD CRITICS RATE ME 1 OUT OF 5 STARS HERE ON BLUELIGHT.ORG ALL WORK UNTIL I Face Palm And Then Leave To Breathe some Life and Learn Intelligent Things.
 
herb.green said:
Then maybe you shouldn't type in all caps. All caps is usually interpreted as yelling, which is usually, you know, rude.

If you are simply looking for a CYP1A2/2B6 inhibitor, then why are you jumping straight to antidepressants and muscle relaxers? Why not stick to something simpler and with less side effects like Tagamet/naringin/grapefruit?
Click to expand...





Can I get SOMEONE WHO KNOWS WHAT THEY'RE TALKING ABOUT I AM USING CAPITALS TO MAKE IT MORE APPERENT AND EASIER TO READ..... Sorry some Arguably Illiterate Individuals Interpret that as YELLING ON THE INTERNET LOL!



Tagamet IS A BRAND NOT A SUBSTANCE MOSTLY REFERRED CIMETIDINE BRAND TAGAMET.... Caps-Lock OFF!: BTW EXCLAMATION MARKS IS! YELLING! JUST! SO! YOU! KNOW! I Purchase Generic Equate Brand MUCH CHEAPER then the Unnecessarily EXPENSIVE TAGAMET and Naringin And Bergamot 500MG Capsule Supplements..... ONLY INHIBITS CYP3A4 MAYBE CYP1A2 But I Do Not Know and Grapefruit has Narngin In it ONLY THE OVER-THE-COUNTER MUSCLE RELAXER IN MY LOCATION SELLS a CYP2B6 Inhibitor A Muscle-Relaxer Orphenadrine which can Act as a Stimulant Unlike Most Muscle-Relaxer you Risk No Respiratory-Respiration To My Knowledge probably so little it doesn't matter because no WARNING WAS ON THE PACKAGE EXCEPT POSSIBLE TO CAUSE INSOMNIA IN SOME PEOPLE AND TO ONLY Dose in the Morning Perfect for Methadone I Am thinking 4 Days And Doses Every 30 Days Or One Dose Every 7 Days LET ME KNOW SOME USEFUL INFORMATION PLEASE PEOPLE!!!!



I Need to Know How well Naringin And Bergamot Inhibit CYP1A2 Rendering Fluoxetine:Brand Name - Prosac Pointless Also What Dose Of Clarithromycin Inhibits CYP3A4 I Am Prescribed 250MG In the Morning and 250MG at Night for 3 Months and some people Say you Need 500-1000MG My Doctor Only Gave Me 250MG Because I Was Worried About Side-Effects and He said it was a Low Dose And should Not Matter But He would give me 500MG Once In Morning Or Once a Night Or even 1250MG or a 1000MG It Might Be Twice A Day Once In Morning Once Later Closer To Night Time. OR MAYBE I SHOULD CREATE A NEW THREAD FOR THESE COMPLICATED QUESTIONS WITH A DIFFERENT TITLE TO ATTRACT MORE PEOPLE WITH KNOWLEDGE ABOUT ALL OF THIS.


I also Need to Know if Eating One Grapefruit NO JUICE Is More Potent than The Juice which May have Expired And Or Destroyed the Bergamot and Naringin Over-Time also is 500MG Of Bergamot and Naringin an Hour before Dosing SUFFICIENT Or Should I Double it to what the Bottle Says 2 Pills Twice A Day Before Meals So would a 1000mg Of Each Be Better.... Don't Tell Me there Is NO WAY TO KNOW BECAUSE YOU SEEM TO KNOW THAT YOU GOTTA DRINK A WHOLE FREAKING 2 LITRES OF GRAPFERUIT JUICE FOR IT TO BE A POWERFUL INHIBITOR WHY IS THAT BECAUSE THAT'S HOW MUCH JUICE IT TAKES FOR HOWEVER MANY MGs Of Bergamott,Naringin and A 3rd Not Yet ISOLATED Supplement Form Inhibitor Hence I still Eat One Whole ACTUAL GRAPEFRUIT REMEMBER I DRINK NO JUICE WHO KNOWS WHAT OTHER INHIBITORS IT GOT.


Any Details I Am Forgetting For All you THREAD CRITICS RATE ME 1 OUT OF 5 STARS HERE ON BLUELIGHT.ORG ALL WORK UNTIL I Face Palm And Then Leave To Breathe some Life and Learn Intelligent Things.
 
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Thomas29 said:
Can I get SOMEONE WHO KNOWS WHAT THEY'RE TALKING ABOUT I AM USING CAPITALS TO MAKE IT MORE APPERENT AND EASIER TO READ..... Sorry some Arguably Illiterate Individuals Interpret that as YELLING ON THE INTERNET LOL!



Tagamet IS A BRAND NOT A SUBSTANCE MOSTLY REFERRED CIMETIDINE BRAND TAGAMET.... Caps-Lock OFF!: BTW EXCLAMATION MARKS IS! YELLING! JUST! SO! YOU! KNOW! I Purchase Generic Equate Brand MUCH CHEAPER then the Unnecessarily EXPENSIVE TAGAMET and Naringin ONLY INHIBITS CYP3A4 MAYBE CYP1A2 But I Do Not Know and Grapefruit has Narngin In it ONLY THE OVER-THE-COUNTER MUSCLE RELAXER IN MY LOCATION SELLS a CYP2B6 Inhibitor A Muscle-Relaxer Orphenadrine which can Act as a Stimulant Unlike Most Muscle-Relaxer you Risk No Respiratory-Respiration To My Knowledge probably so little it doesn't matter because no WARNING WAS ON THE PACKAGE EXCEPT POSSIBLE TO CAUSE INSOMNIA IN SOME PEOPLE AND TO ONLY Dose in the Morning Perfect for Methadone I Am thinking 4 Days And Doses Every 30 Days Or One Dose Every 7 Days LET ME KNOW SOME USEFUL INFORMATION PLEASE PEOPLE!!!!



I Need to Know How well Naringin And Bergamot Inhibit CYP1A2 Rendering Fluoxetine:Brand Name - Prosac Pointless Also What Dose Of Clarithromycin Inhibits CYP3A4 I Am Prescribed 250MG In the Morning and 250MG at Night for 3 Months and some people Say you Need 500-1000MG My Doctor Only Gave Me 250MG Because I Was Worried About Side-Effects and He said it was a Low Dose And should Not Matter But He would give me 500MG Once In Morning Or Once a Night Or even 1250MG or a 1000MG It Might Be Twice A Day Once In Morning Once Later Closer To Night Time. OR MAYBE I SHOULD CREATE A NEW THREAD FOR THESE COMPLICATED QUESTIONS WITH A DIFFERENT TITLE TO ATTRACT MORE PEOPLE WITH KNOWLEDGE ABOUT ALL OF THIS.


I also Need to Know if Eating One Grapefruit NO JUICE Is More Potent than The Juice which May have Expired And Or Destroyed the Bergamot and Naringin Over-Time also is 500MG Of Bergamot and Naringin an Hour before Dosing SUFFICIENT Or Should I Double it to what the Bottle Says 2 Pills Twice A Day Before Meals So would a 1000mg Of Each Be Better.... Don't Tell Me there Is NO WAY TO KNOW BECAUSE YOU SEEM TO KNOW THAT YOU GOTTA DRINK A WHOLE FREAKING 2 LITRES OF GRAPFERUIT JUICE FOR IT TO BE A POWERFUL INHIBITOR WHY IS THAT BECAUSE THAT'S HOW MUCH JUICE IT TAKES FOR HOWEVER MANY MGs Of Bergamott,Naringin and A 3rd Not Yet ISOLATED Supplement Form Inhibitor Hence I still Eat One Whole ACTUAL GRAPEFRUIT REMEMBER I DRINK NO JUICE WHO KNOWS WHAT OTHER INHIBITORS IT GOT.


Any Details I Am Forgetting For All you THREAD CRITICS RATE ME 1 OUT OF 5 STARS HERE ON BLUELIGHT.ORG ALL WORK UNTIL I Face Palm And Then Leave To Breathe some Life and Learn Intelligent Things.
Click to expand...

Hope you Od man. We need less junkies like you in the world.

RABBLE RABBLE RABBLE RABBLE RABBLE RABBLE RABBLE RABBLE RABBLE RABBLE

GOOBLE GOBBLE GOOBLE GOBBLE GOOBLE GOBBLE
 
Can we keep this Constructive I just took Fluoxetine Brand Name Prosac and going to get a Prescription for it But it can Last Anywhere from 24-72 Hours so would Using it ONCE EVERY 10 DAYS 3 times a month instead of once a week 4 times a month or should i use it Once a month Possibly Twice A Month I Am on the Every 10 Day Cycle Guess Here? Anyone with Any Knowledge of a better For 2C19 I think it is lol.
 
Thanx for the Docile Non Replies.... Shows you all got knowledge but not TRUE SMARTS! I CAN ADMIT THAT! Hence I Verify Shit ANYWAYS MY PHARMACY Said Orphenadrine is Over The Counter But they had to Order some and it's in and I Am about to Buy 20 100mg Orphenadrine Pills But I think it might have some else in it I will Update I Assume because its the ONLY Inhibitor FOR THIS ENZYME that 100mg or the Recommended Package Dose For Such A New Medication it is Not even One Year Since it became Over The Counter Or By Prescription Or Approved For Human Consumption even Water Bottle Companys prob gotta do half a decade of safety tests/trials lol. It is Not Even Stocked in Many Stores Yet But if anyone can Do some Research because I Googled and Found Nothing But if you Know where to Look for an Educational RESPONSIBLE SAFE Guess for the Dosage it would be Greatly Appreciated. I can Not Buy Cimetidine in Canada,Ontario I got to Buy it from the U.S.A. But Maybe just Like Tylenol 1's Are Over the Counter HERE WITH Caffeine which I think Orphenadrine Also It is NOT SEDATIVE UNLIKE MOST MUSCLE-RELAXERS IT CAN BE STIMULATING AND WARNS OF INSOMNIA AND I CAN CONFIRM MASS UNEXPLAINABLE EUPHORIA FROM CODEINE especially since I Hate it and I can't See how it would Effect ANYTHING BUT THE CAFFEINE I Noticed the Orphenadrine Syngergized with the Caffeine and somehow made a magical buzz with weed and codeine lol. I think it has in it and maybe Tylenol or Choice of OTC Painkiller maybe an Anti-Histamine.
 
OPRHENADRINE 100% STOPS METHADONE METABOLISM TO THE POINT SOMEONE WHO WAS TAKING THIS OVER THE COUNTER ORPHENADRINE A MUSCLE RELAXER DERIVED AND STRUCTURED LIKE DIPHENHYDRAMINE THEY DIED FROM OVERDOSING ON THERE SAME EVERY METHADONE MAINTENANCE DOSAGE!

sooo DANGER HELP WITH ADVICE!


i would assume when it says lasts Minimum of 13 Hours and that doubles when taken for enough Days in A Row to Lasting a Minimum of Hours Does that Mean if i take Orphenadrine will Stop Methadone from Leaving my System at all for 13 Hours it PLUGS 2B6 90%-100% SAME WITH EVERY OTHER ENZYME KNOWN TO metabolize methadone and considering someone died on this combination mind you they prob took it for more then a few days and least a week or two maybe month i'd imagine considering i took it for 3 days before i Realized How DANGEROUS 2B6 INHIBITION CAN be




I guess i will create a new thread if i cant get a reply here.
 
So I Been Trying 25MG 50MG 75MG Or 100mg And 150MG But Only Differneces is Not Noctiably Apperent. Well I HAVEBNT DIED NO THANX TO ANY INFORMATION ACQUIRED HERE AND MIGHT JUST KICK THE BUCKET BY USING 150MG BEFORE MY DOSE WHEN 25MG IS MORE THE ENOUGH FOR INHIBITION WITHOUT INCREASE RISK OF DEATH LIKE USING SAY 150MG BUT FUCK IT THAT IS ONLY THE REASON WHY THIS STILL WAS CREATED AND STILL EXISTS FOR IN REALITY A.K.A. REAL-LIFE! BUT THIS IS BLUE-LIGHT.RU AND THOMAS29 MEANS L,ESS THEN THE THOMAS IN REAF LIFE WHO MIGHT DIE SINCE WELL I'M WORTH LESS THEN A LIVIN LIKE A HOBO'S LIFE WHO OVERDOSED LEAST THAT POOOR SAP HAD IT HARD AND IS OUTTA HIS MISERY ME I GOT SO MUCH TO LIVE FOR AND DESERVE IT FOR NOT KNOWING TO NOT BE DUMB AND TAKE 150MG WHEN 25MG would of done the Job while Keeping Me Awhile At The Same Time BUT PLEASE DO IGNORE THIS THREAAD AND IF YOU READ BE SURE NOT TO REPLY ANYTHING USEFUL EXCEPT SOMETHING JUDGMENTAL LIKE "Take A Look in the Mirror before Posting about Recommended Dosages" Just because you got No Good Answer And Like Adding TO your Post Count Another OnE Of YOUR cOUNTLESS aDDICTIONS.
 
Uh I don't think anyone is not responding to your thread out of malice, but rather due to the fact that not many here are qualified hepatologists. At least that's the case here, I wouldn't want to give advice that could cause an OD, so you see, it's quite the contrary to what you are insinuating. Also reading your posts really does feel like you are screaming into my brain, just sayin.
 
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