Yes, very true…. Ritalin (Methylphenidate) and Cocaine are nearly identical in their MOA. Both being “Inverse Agonists” at the monoamine transporters DAT/SERT/NET.….both drugs cause the increase & release of dopamine in the CNS region responsible for pleasure & reward
Ritalin (Methylphenidate) is actually nearly 2X more potent than Cocaine as per their ED-50 (Effective Dose to inhibit 50% of the DAT - which is required to induce euphoria
Ritalin (Methylphenidate) - DAT>NET (3-4 X more active at DAT than the NET)
Cocaine - DAT>SERT>> NET
(Cocaine is the perfect balance more active at Dopamine & Serotonin, with Norepinephrine lagging behind, but still essential . 100% pure Pharmaceutical Cocaine HCL “small fluffy crystals” WARNING: May be habit forming lol
…..intravenous injection of pharmaceutical Cocaine & Diamorphine (Heroin) would be an atomic bomb of dopaminergic/opioid euphoric pleasure
Diamorphine (Heroin) - 4 parts
Cocaine - 1.5 parts
Ketamine - 0.5 parts
….all in a single 1cc 30 gauge insulin syringe…….WOW, 3-5 seconds to lift off …..that warm RUSH of overwhelming Euphoric Bliss, …..the Cocaine adding SIGNIFICANTLY to the unreal pleasure of this cocktail, the ultimate antidepressant in low therapeutic safe doses, Dopamine, Serotonin, and Norepinephrine all RAPIDLY increased & released in the CNS in addition to Diacetylmorphine’s warm safe cozy blanket of euphoric pleasure almost unreal its so overwhelming euphoric & pleasurable……truly an atomic bomb of pleasure in the brains centre for pleasure & reward
Ritalin (Methylphenidate)
Phenmetrazine (Preludin)
Amphetamine (Benzedrine/Dexedrine/Adderall)
Methamphetamine (Methedrine/Desoxyn)
Cocaine (illicit)
Ritalin & Phenmetrazine were Extremely desirable with hi-dose intravenous injection users for their insanely euphoric rush. Phenmetrazine (Preludin) was actually preferred over Methamphetamine (Methedrine & Desoxyn) for i.v. injection as it provided a significantly more pleasurable rush, and more of a sexual orgasmic euphoric rush. It was actually removed from the market due to its very high abuse potential …pure pharmaceutical API raw powder for injection, both Phenmetrazine & Ritalin (Methylphenidate) alike.
Cocaine users in a controlled study had difficulty differentiating between intravenous Cocaine or Ritalin (Methylphenidate) as their MOA is basically identical, except for Cocaine has prominent Serotonin properties as Ritalin does not. In any account…..that study is very interesting
same with studies comparing Morphine and Diacetylmorphine (Heroin) ….both were very desirable and dosed correctly sometimes difficult to distinguish. Identical results for injectable Hydromorphone (Dilaudid) to be given in place of Diacetylmorphine (Heroin) which didn’t require the stringent licensing requirements. HM was nearly indistinguishable from Diamorphine.
again, same with Amphetamines …..injections of racemate Amphetamine Sulphate, dextro-Amphetamine & dextro-Methamphetamine. All three amphetamines were very desirable and pleasurable and frequently difficult to differentiate between the test subjects ….even though Desoxyn (D-Methamphetamine) has significant Serotonin activity and much more water soluble, most likely penetrating the BBB much more rapidly causing a fast RUSH of significant euphoric bliss.