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Cross-tolerance with 25c nbome?

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mowoff

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Dec 1, 2012
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I was wondering if anyone here was experienced with nbome products or knowledgeable enough to be able to help me out.

As far as I know, both MDMA and Nbomes affect 5H-T receptors or the seratonin system in some way so is there any cross-tolerance issues between them?
 
NBOMes have some CRAZY cross tolerance with almost all serotonergic drugs.. they have something like 16 times the affinity for the 5-HTa receptor as other classical psychedelics , like as the drug it was derived from (2C-I), and as such causes heavy tolerance that will take weeks (or months, with heavy use) to dissipate.



I would tread very lightly with this class of drugs, the NBOMes are some weird fuckers.




I'm going to move this over into Psychedelic Drug Discussion as I think you'll get better answers there, but do know that MDMA and the NBOMes will have some significant cross tolerance
 
Well pharmacologically they have only partially shared action:

NBOMe compounds are strong partial to full agonists at the 5-HT2A receptor which is a subtype of serotonin receptor responsible for psychedelic effects.

MDMA and its metabolite MDA are also agonists, but much weaker ones. Because this action is shared you can expect this part of effects from MDMA to be reduced.

However MDMA also releases monoamines and this is the main part of the action.

I guess it is hard to say whether MDMA is less magical or empathogenic without the agonism at the 2A receptor or if the cross-tolerance would also affect how your 2A receptors respond to the increase in synaptic serotonin levels.

I'd wait half a week before taking any MDMA but a whole week is better as a minimum. NBOMe effects are not well understood so cross tolerance isn't either. Taking these drugs with disregard for such interactions may disappoint you in the long run because it is possible you react less and less desirable if you stress your serotonergic system too much.
 
Thanks for the answers guys, will probably just not bother with nbomes in that case.
 
I had taken 25i-nbome one day before taken 6-apb on the recommendation of someone that this would cause less tolerance build up than taking 6-apb the 1st day and 25i-nbome the second. I forget the reasoning but anyways this was wrong.

The experience with the 6-apb 1 day after the nbome was greatly reduced even though the main action to enjoy with the 6-apb wasn't visual anyways. I have no idea if taking the 6-apb day one and nbome day 2 would have worked better. I know your question was MDMA but hopefully my experience helps you a little.
 
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