Cross-tolerance of LSA and mescaline?

[slimvictor]

Does anyone know about studies (or have personal experience) regarding cross-tolerance of LSA and mescaline?
I have read that LSD and mescaline show cross-tolerance, but never read anything about LSA.

(Just to be clear, by "cross-tolerance" I am referring to a situation such as this one: you take some LSD on Monday, and if you take your normal dose of mescaline on Wednesday, you won't get as high as normal.)

Thanks for any information you have.

 

[Help?!?!]

I personally never noticed much of a cross tolerance between LSD and any phen IMO. If anything it barely muted it slightly.

 

[Solipsis]

There is partial tolerance and activity overlap for all basically all such serotonergic drugs, not to mention psychological tolerance (which may just be just about the same). I'm not saying it's very big but effects of a second compound may be somewhat diminished after you have taking a serious dose of a first drug not too long before that. If there is very little time in between you might also get synergy rather than tolerance - it's hit or miss (no pun intended).

So to put it more simply: probably a little bit but the more they differ the less it will matter.

 

[digital_phreedom]

In my experience the tolerance exhibited was mostly for the mental effects.. The "mindfuck" wasn't as strong when I use mescaline that soon after LSD. But the body effects and visual effects seem to be about the same.

I'm too lazy to look it up right now, but if mescaline shows activity at 5-HT2A receptors like LSD, most chemicals that work in that area show some kind of cross-tolerance. Not all though.. And Phen's can be really weird in the whole tolerance department anyway. So not sure about technical stuff, but that's my experience.