Short answer: don't do it
longer answer: Past weekend I took 8mg 2C-E on friday and 0.7gr dried mushrooms on saturday. The mushrooms got me harder than i expected. Of course this is phen-tryp as were you plan on taking 2 tryps in a row.
Still I think it's doable, it all depends on the dose. If you dose +20mg 4aco-det, I don't think you'll be feeling much of the 5meomipt. But do sth like 15mg 4aco-det and the next day 3-7mg 5meomipt and I think you will hae a nice weekend !