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Pharmacology Crisugabalin discussion

This thread contains discussion about a Pharmacology-related topic

TheLightBringer

Bluelighter
Joined
May 25, 2022
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675
Similar to what I posted in another thread

Decently new VGCC blocker being used only in china as far as I know. Havent done much research on it yet so Ill return and update this thread but thought id bring some attention to it….

I havent seen a lot of discussion on this one except two mentions on reddit and zero user reports.

Looked through some of the studies (the translation on phone browser for the chinese ones is horrific and leads to many nonsensical mistranslations though) but at first glance it seems like a VGCC a2-delta blocker. Lasted 24 hours as opposed to 12 like pregabalin and showed 23x more potency at binding compared to pregabalin. Despite this it seems 10mg/kg Crisugabalin was ”only” as effective as 30mg/kg pregabalin. This was in rats though so take with a grain of salt
 
Fuck I really picked an unfitting time to read about this compound, currently falling asleep with my phone in my hand. Ill be back tomorrow and try to come with something more constructive 😪
 
Seems to be more potent and longer lasting

Also has less abuse potential according to animal models. I wonder if they accounted for longer duration. Otherwise why would it have less abuse potential (perhaps measured by redosing) if it's just better and stronger?
 
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