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DNA May Influence How Much Caffeine People Consume, Researchers Say
By Bill Hendrick
WebMD Health News Reviewed by Laura J. Martin, MD
April 7, 2011 -- DNA may play a large role in determining how much caffeine people consume in beverages such as coffee, tea, and soda and food such as chocolate, new research indicates.
Scientists from the Harvard School of Public Health, the National Cancer Institute, and other institutions say they have discovered two genetic variations that influence the metabolism of caffeine and are associated with how much caffeine people consume. People with particular variations of two specific genes are more likely to consume caffeine, and to drink more of it when they do, study leader Marilyn C. Cornelis, PhD, of the Harvard School of Public Health, tells WebMD.
Genes and Coffee
The genes are identified as CYP1A2, long known to play some role in caffeine metabolism, and another called AHR, which affects regulation of CYP1A2.
All people have both genes, but the study, involving more than 47,000 middle-aged Americans of European descent, finds that people with the highest-consumption variant for either gene consumed about 40 milligrams more caffeine than people with the lowest-consumption gene varieties. Forty milligrams is the equivalent of 1/3 cup of caffeinated coffee or one can of soda.
cont at
http://www.webmd.com/food-recipes/news/20110407/crave-caffeine-it-may-be-in-your-genes
By Bill Hendrick
WebMD Health News Reviewed by Laura J. Martin, MD
April 7, 2011 -- DNA may play a large role in determining how much caffeine people consume in beverages such as coffee, tea, and soda and food such as chocolate, new research indicates.
Scientists from the Harvard School of Public Health, the National Cancer Institute, and other institutions say they have discovered two genetic variations that influence the metabolism of caffeine and are associated with how much caffeine people consume. People with particular variations of two specific genes are more likely to consume caffeine, and to drink more of it when they do, study leader Marilyn C. Cornelis, PhD, of the Harvard School of Public Health, tells WebMD.
Genes and Coffee
The genes are identified as CYP1A2, long known to play some role in caffeine metabolism, and another called AHR, which affects regulation of CYP1A2.
All people have both genes, but the study, involving more than 47,000 middle-aged Americans of European descent, finds that people with the highest-consumption variant for either gene consumed about 40 milligrams more caffeine than people with the lowest-consumption gene varieties. Forty milligrams is the equivalent of 1/3 cup of caffeinated coffee or one can of soda.
cont at
http://www.webmd.com/food-recipes/news/20110407/crave-caffeine-it-may-be-in-your-genes
