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Opioids Concerned About the Acetaminophen in my Percocets?

A

AnnCognito

Greenlighter
Joined
Feb 25, 2014
Messages
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I am a casual Percocet user (actually I think the name of the pill is Endocet, which is the same thing). Here’s my issue. Once a month, usually around the end of the month or the beginning of the next month, I get about 30 Endocets, 10mg Oxy / 325mg Acetaminophen. These pills are IMPOSSIBLE to find where I live, so I can only get them from this person I know once a month. I started taking 2 pills when I first started. Now I’m up to 4 at a time and it’s slowly losing it’s luster. Taking 4 pills at a time = 1300mg of Acetaminophen. I didn’t really like that, but when I take them, I only take them that one time per day (maybe twice, if I’m having a super shitty day). So that means I RARELY go over 1300mg per day and I definitely NEVER go over 2600mg per day. Now I’m nervous to up the amount of pills I take at one time to 5 because that’d be 1625mg of Acetaminophen and I am afraid of what that will do to my liver. My question is could 1625mg of Acetaminophen in one sitting be damaging to me if I only do it once a day for like 6 days out of the month?
Thanks
 
I always CWE if I am going to take more than 1000mg at one time. 1600mg will most likely be ok once but APAP is really not good for you.

As it seems your use and tolerance is slowly increasing, it is good practice to get in the habit of CWEing. It is so easy, there is no real reason not to.

The government is always lowering the daily max recommended amount of APAP. In my mind, it is much better to deal with a 20 minute CWE than worry about if I am damaging my liver.
 
The last time I checked the FDA says 4 grams of acetaminophen in 24 hours is the recommended cutoff limit. You're probably fine.
 
I wouldn't sweat it until you start pushing 3-4g in a single day.

there is some waste involved with the CWE process, and it's pretty silly to go to all that trouble when you're under the 4g threshold.
 
Oxide said:
I wouldn't sweat it until you start pushing 3-4g in a single day.

there is some waste involved with the CWE process, and it's pretty silly to go to all that trouble when you're under the 4g threshold.
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This.

I used to take 10/325's of oxycodone/APAP but I was taking 4g of APAP daily and I rarely CWE'd because I'd use the rectal ROA and APAP is not absorbed well via the rectal ROA (and the oxycodone would last about 1.5-2x longer than oral dosing). I wasn't cool with taking 4g a day so I asked my doctor about eliminating the APAP and then I switched to roxicodone, and never looked back.
 
Oxide said:
I wouldn't sweat it until you start pushing 3-4g in a single day.

there is some waste involved with the CWE process, and it's pretty silly to go to all that trouble when you're under the 4g threshold.
Click to expand...

CWE makes it hit like a freight train tho.
 
If your gonna continue to use find some roxy 15 or 30s tyenol is really bad for you
 
You can consult with your doctor about switching the amount of APAP that you are currently taking in you narcs.
 
^Well, like tricomb said, the next logical step is switching to straight oxycodone in higher dosage units...It's not like there's these "super secret percocets" with only 162.5 mgs of APAP as opposed to 325..but yes, the OP should talk to his doctor about it, I agree...
 
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^I was nitpicking I suppose!;). But you can't "lower" the amount of APAP, only switch to a med without one, but that's what you probably meant, and other than a CWE, that's the only option for the OP.
 
Didn't the FDA lower the daily max to 3g?

At any rate, you have to start worrying about liver damage if you're taking lots of apap every day or are a chronic drinker. I used to eat endocets like they were tic-tacs, and those were the ones formulated with 650mgs each. Don't think those are made anymore, however.
 
BlueHues said:
^I was nitpicking I suppose!;). But you can't "lower" the amount of APAP, only switch to a med without one, but that's what you probably meant, and other than a CWE, that's the only option for the OP.
Click to expand...

exactly what I meant, just worded wrong.
 
Your liver will take A lot more than you may think - the human body is very resilient, if you really think about it. Us humans, mammals, and heck most other species are programmed for SURVIVAL.

Now this doesn't give you an excuse, reason, or what-have-you to abuse your body, simply because it can handle. The liver is an important organ.

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Oh yeah, and everybody is different. Not everyone's liver will take the stress..Just CWE.
 
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Up to 5 grams Tylenol if you weigh around 150 lb will be fine. If you are young and healthy you can tax your liver for a few days a month. Look up LD 50, use less than half of the reported amount and you will always be safe.
 
Going off of the LD50 of APAP isn't a good idea. Most of the information we have regarding acetaminophen toxicity is speculative at best, and it's not even the parent compound that is toxic, but one of it's metabolites, and none of know exactly how we metabolize things on a day-to-day basis. Things like food, other medication we don't even think about, and other factors affect the metabolic pathways of our liver.

I would say limiting a single dose to 2.5-3g of APAP (as long as you wait at least 6-12 hours before consuming anymore) once every blue moon would be safe, but if you're wanting to go above that, be sure to do a CWE.
 
So plugging doesn't make the apap go to the liver or what? I never heard this tell me more if you don't mind. Thanks Jman
 
pluggingstuff cant be healthy either though,
think about it.

even our stomachs and upper intesttines aren't meant to digest pharmaceutical drugs..
 
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