Originally posted by fairnymph:
Yeah, you should DEFINITELY taper off an SSRI....I went of prozac basically cold turkey and fell into a month long depression....not fun.
I would do anywhere from a week to month long taper, depending on the dose of citalopram you were on, and for how long your were taking it. Definitely take your dose if the withdrawal is bad.
As for WHY there is withdrawal from the SSRIs, well, these drugs change the way that you brain function. They increase your serotonin levels and also cause downregulation of serotonin receptors. Thus, when you go off the SSRI, your serotonin levels drop (because serotonin reuptake in no longer being inhibited) but your serotonin receptors are still downregulated! This means that not only do you lack serotonin, but you also lack serotonin receptors, and this leads to depression and a variety of withdrawal symptoms. It takes a while for your brain to upregulate its serotonin receptors, and this is why you should always taper...
I did a fairly stupid thing lately. I went off my SSRI (Paxil) briefly (what I thought was for a weekend). Decided if I noticed withdrawal I'd substitute Celexa. Didn't notice any, and the weekend turned into a week with no visible side effects.
I got home, and went back on Paxil. My levels had obviously dropped sufficiently, because I started getting withdrawal. Mainly there weren't physical side effects but I had a higher sex drive and was much more prone to bad moods....which is really just like being a normal person, I guess (how SSRIs have spoiled me).
My levels rose again over days and then i noticed more effects from going back ON (yawning, etc, the transients) than my 'withdrawal'.
Another week later, I appear to be back to wonderful.
-u40915, repaxillated