AI Recovery Info
Credit: verybigguy
Summary of Potential Remedies to Accelerate Recovery from Invega/Xeplion (Paliperidone)
Neurochemical Context:
Invega/Xeplion (paliperidone) blocks dopamine D₂ and serotonin 5-HT₂A receptors, disrupting frontal cortex function (critical for motivation, emotion, and cognition). Its long-acting injectable form (half-life: 25–49 days) sustains receptor blockade for months, leading to symptoms like emotional numbness, loss of inner monologue, and apathy. Chronic use may reduce neuroplasticity (via low BDNF) and cause dopamine receptor supersensitivity, complicating recovery.
- L-Tyrosine (500–2000 mg/day): Precursor for dopamine synthesis, countering D₂ receptor blockade.
- Mucuna Pruriens (100–300 mg): Contains natural L-DOPA for direct dopamine support.
- Exercise: Aerobic activity boosts BDNF and dopamine sensitivity (e.g., 30-minute walks).
- L-Tryptophan (500–1000 mg/day): Serotonin precursor to counteract 5-HT₂A blockade.
- Omega-3s (EPA/DHA) (1–2 g/day): Reduce inflammation and support serotonin pathways.
- Adaptogens (Ashwagandha, Rhodiola): Modulate stress responses and improve resilience.
- N-Acetylcysteine (NAC) (600–1200 mg 2x/day): Restores glutathione (antioxidant) and balances glutamate.
- Lion’s Mane Mushroom (1–3 g/day): Stimulates nerve growth factor (NGF) for synaptic repair.
- Magnesium L-Threonate (144 mg/day): Enhances NMDA receptor function and calms glutamate overactivity.
- CoQ10 (100–300 mg/day): Improves cellular energy production.
- B-Complex Vitamins: Critical for dopamine/serotonin synthesis (B6, B9, B12).
- Probiotics (e.g., Lactobacillus rhamnosus): Improve gut health, linked to dopamine/GABA production.
- Cold Exposure (cold showers/cryotherapy): Boosts norepinephrine/dopamine by 200–300%.
- Intermittent Fasting: Promotes autophagy (cellular cleanup) and ketosis for brain repair.
- Transcranial Magnetic Stimulation (TMS): Non-invasive stimulation of prefrontal cortex to restore motivation.
- Cognitive Remediation: Puzzles, reading, or structured therapy to "retrain" frontal cortex function.
- Mechanism: Acts as a mild SSRI/MAO inhibitor but interacts with many drugs (e.g., reduces antipsychotic efficacy).
- Risk: Serotonin syndrome if combined with SSRIs. Safer alternatives: L-tryptophan, omega-3s, or adaptogens.
- Gradual Tapering: Essential to avoid rebound psychosis. Work with a psychiatrist for dose reduction.
- Avoid Dopamine Overstimulation: High-dose tyrosine/mucuna may trigger anxiety/psychosis in sensitive individuals.
- Frontal Cortex Focus: Combine aerobic exercise, mindfulness, and cognitive challenges to rebuild executive function.
- Timeline: Recovery may take 6+ months due to the drug’s long half-life. Synergistic strategies (e.g., NAC + exercise + omega-3s) are ideal.
- Walking: Users report improved mood and cognition during early withdrawal, likely due to BDNF release.
- Meditation/Mindfulness: Reduces stress-induced cortisol, supporting neuroplasticity.
Recovery from Invega/Xeplion’s effects requires a multi-pronged approach: repairing dopamine/serotonin pathways, reducing neuroinflammation, and stimulating neuroplasticity. Prioritize
dietary supplements (tyrosine, NAC, omega-3s),
lifestyle changes (exercise, fasting), and
innovative therapies (TMS, cold exposure) while avoiding risky interactions (e.g., St. John’s Wort). Always collaborate with a healthcare provider experienced in antipsychotic withdrawal to tailor strategies safely.
Key Takeaway: While no single remedy guarantees rapid recovery, combining these approaches may accelerate the brain’s return to baseline function, particularly in the frontal cortex.
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Greenlighter
Today at 11:03 PM
Gradual Tapering: Essential to avoid rebound psychosis. Work with a psychiatrist for dose reduction.
Complete bullshit though it's impossible to get psychosis again when your brain is already nuked by the insane half life of the drug.
- Mechanism: Acts as a mild SSRI/MAO inhibitor but interacts with many drugs (e.g., reduces antipsychotic efficacy).
That's actually the exact effect we want, so honestly I'd recommend it reading this, even though I can't confirm it really worked. Though I just had one bottle.
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Greenlighter
Today at 11:08 PM
Here's another one purely from deepseek. Chinese AI clearly less filtered/censored
Paliperidone primarily blocks
dopamine D2 and
serotonin 5-HT2A receptors. Long-term use, especially via injections (half-life: 25–49 days), can lead to:
- Dopamine receptor supersensitivity: Chronic blockade may cause upregulation of D2 receptors, contributing to withdrawal symptoms like agitation or psychosis.
- Frontal cortex dysfunction: Reduced dopamine and serotonin signaling in this region impairs executive function, motivation, and emotional regulation.
- Glutamate/GABA imbalance: Indirect effects on NMDA/glutamate pathways may worsen cognitive blunting.
- Neuroplasticity deficits: Long-term receptor blockade may reduce BDNF (brain-derived neurotrophic factor), critical for synaptic repair.
These changes explain symptoms like emotional numbness, loss of inner monologue, and catatonia.
- L-Tyrosine: A dopamine precursor. Dose: 500–2000 mg/day. Supports natural dopamine synthesis, countering D2 receptor blockade.
- Mucuna Pruriens (Velvet Bean): Contains L-DOPA, directly boosting dopamine. Dose: 100–300 mg standardized extract.
→ Caution: Start low to avoid overstimulation (risk of anxiety or psychosis in sensitive individuals).
- St. John’s Wort: Acts as a mild SSRI and MAO inhibitor. May help restore serotonin balance post-5-HT2A blockade.
→ Dose: 300–600 mg standardized extract (0.3% hypericin).
→ Risks: Serotonin syndrome if combined with SSRIs; reduces efficacy of other drugs (e.g., birth control).
- Omega-3 Fatty Acids (EPA/DHA): Reduce neuroinflammation and support BDNF. Dose: 1–2 g/day.
- N-Acetylcysteine (NAC): Restores glutathione (antioxidant) and modulates glutamate. Dose: 600–1200 mg twice daily.
- Lion’s Mane Mushroom: Stimulates nerve growth factor (NGF). Dose: 1–3 g/day.
- Magnesium L-Threonate: Crosses the blood-brain barrier, calming NMDA hyperactivity. Dose: 144 mg elemental magnesium/day.
- Taurine: Enhances GABA signaling. Dose: 1–3 g/day.
- Coenzyme Q10: Improves cellular energy production. Dose: 100–300 mg/day.
- B-Complex Vitamins: Critical for dopamine synthesis (B6, B9, B12).
- Probiotics: Strains like Lactobacillus rhamnosus increase GABA and dopamine.
- Vitamin D3: Low levels correlate with depression; supports serotonin synthesis. Dose: 2000–5000 IU/day.
- Aerobic Exercise: Increases BDNF and dopamine receptor sensitivity. Even walking 30 mins/day helps.
- Intermittent Fasting: Promotes autophagy (cellular cleanup) and ketosis, which may repair dopamine pathways.
- Transcranial Magnetic Stimulation (TMS): Non-invasive brain stimulation targeting the prefrontal cortex.
- Amantadine: NMDA antagonist and dopamine agonist. Used off-label for antipsychotic-induced apathy.
- Agomelatine: Melatonin agonist + 5-HT2C antagonist. Improves sleep and mood without serotonin risks.
- Microdosing Psilocybin: Anecdotal reports suggest it restores emotional depth and creativity by modulating 5-HT2A receptors. Caution: Legal risks and lack of clinical data.
- Cold showers or cryotherapy boost norepinephrine and dopamine by 200–300%, potentially countering emotional blunting.
- The injection’s 6-month washout period means recovery is gradual. Combining strategies (e.g., exercise + NAC + tyrosine) may synergize.
- EEG Neurofeedback: Targets frontal cortex activity to restore cognitive flexibility.
- St. John’s Wort: Avoid with SSRIs, antipsychotics, or birth control.
- Dopamine agonists: Risk of mania/psychosis in predisposed individuals.
- Gradual tapering: Essential to avoid rebound psychosis. Work with a psychiatrist open to integrative approaches.
@youwillrecoverhere i was just tired of all this bs and attacking me for being too enlightened but i love you all. @paliperidonevictim2005 you were close i landed in jail because my parents sued me for 7 years of abuse from 2018-2025. They did this because i was about to post on Facebook to all their friends neighbours and family what kind of abuse been at this home and how they actively use fake schizophrenia diagnosis on me while im calm and doing nothing wrong. The day i was about to post it 2 cops entered my room and brutally handcuffed me and send me 1 day to prison cell then next day sergeant interrogated me for 2 hours where i explained what is really going on and how actually they are the abusers not me which fortunately he believed and when we finished and camera stopped recording he said "you shoot yourself in foot by living with them". If he was dumb i could be still in jail waiting for court case. The amount of evil they have to their own son is insane. I never been this broken after what hospitals did to me and they do this... I guess they rather see me dead then happy and truthful. @TonyTonyChopper you are forgiven homie all love hahah
it really helps when strangers give you validation after my own parents do such an hell on me. Im not psychotic. I just had ctpsd from abuse and they misdisgnosed it because nothing heals trauma as rage especially when family abuses me in the moments when i should receice love and emapthy. I dont wanna run tho i still wanna hit the biggest antipsychiatric case in history of this fookin country. I pray to God IT will happen! Someone has to stop this madness of chemical torturę on people needing a hug. Jesus Christ is my lord and saviour 
